Peptide ligand
The thrombin receptor extracellular domain contains sites crucial for peptide ligand induced activation
... of peptide ligand-mediated activation phenomenon, we have isolated, cloned, and stably expressed the identical receptor from a human umbilical vein endothelial cell (HUVEC) ...and peptide ...
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Affinity Interaction between Hexamer Peptide Ligand HWRGWV and Immunoglobulin G Studied by Quartz Crystal Microbalance and Surface Plasmon Resonance.
... between ligand and protein the QCM sensor needs to be functionalized by attaching the peptide ...immobilized ligand density can affect the interactions between the peptide ligands and the ...
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Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby
... T cell reactivity to minor histocompatibility (mH) antigens is responsible for rejection of HLA- matched allografts, limiting the effectiveness of transplantation for the treatment of end-stage organ failure. The deadbox ...
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Targeting bladder tumor cells in voided urine of Chinese patients with FITC-CSNRDARRC peptide ligand
... Materials and methods: Between March 2011 and September 2011, 80 consecutive patients with radiographic abnormalities, localizing hematuria, other symptoms, or signs were studied using the FITC-CSNRDARRC ligand, ...
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Peptide ligand and PEG-mediated long-circulating liposome targeted to FGFR overexpressing tumor in vivo
... Background and methods: Paclitaxel, a widely used antitumor agent, has limited clinical application due to its hydrophobicity and systemic toxicity. To achieve sustained and targeted delivery of paclitaxel to tumor ...
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Single peptide ligand-functionalized uniform hollow mesoporous silica nanoparticles achieving dual-targeting drug delivery to tumor cells and angiogenic blood vessel cells
... The lower uptake efficiency of pHMSN compared with that of HMSN can be explained by the sterically hindered effects of PEG chains grafted onto the surface of nanoparticles. However, compared with HMSN and pHMSN, tHMSN, ...
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Structure-guided discovery of a single-domain antibody agonist against human apelin receptor
... 30 peptide ligand analogs, target ...gene–related peptide receptor antagonist, for migraine prevention (4), and mogamulizumab, a CCR4 neutral binder with antibody-dependent cellular cytotoxicity in ...
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... endogenous ligand of Apelin Receptor ...cognate peptide ligand, apelin and many physiological effects, including vasodilation, vasoconstriction, angiogenesis, fluid homeostasis, neuroendocrine ...
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Analog peptides of type II collagen can suppress arthritis in HLA DR4 (DRB1*0401) transgenic mice
... altered peptide ligand is its ability to alter the cytokine profile of responding T ...type peptide was predominantly IFN-γ and ...wild-type peptide at low doses (10 µg/ml), secretion of IFN-γ ...
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Transcriptome-wide analysis of differentially expressed chemokine receptors, SNPs, and SSRs in the age-related macular degeneration
... genes), peptide ligand-binding recep- tors (27 genes), class A/1 (rhodopsin-like receptors) (47 genes), GPCR ligand binding (53 genes), signal trans- duction (126 genes), innate immune system (59 ...
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RPK2 is an essential receptor like kinase that transmits the CLV3 signal in Arabidopsis
... small peptide ligand derived from CLV3 is perceived by two major receptor complexes, CLV1 and CLV2-CORYNE (CRN)/SUPPRESSOR OF LLP1 2 (SOL2), to restrict WUSCHEL ( WUS ) ...CLV3 peptide (MCLV3) to ...
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Construction of a Gammaretrovirus with a Novel Tropism and Wild-Type Replication Kinetics Capable of Using Human APJ as Entry Receptor
... 13-amino-acid peptide ligand for hAPJ, flanked by linker sequences, into one of the variable loops of the receptor binding domain of SL3-2, a murine leukemia virus (MLV) that uses the xenotropic-polytropic ...
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Multiple sclerosis
... Data from a number of laboratories combined with experimental data from the EAE model where myelin antigen is injected with adju- vant into mammals indicate that there are autoreactive T cells recog- nizing myelin ...
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Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen
... targeting ligand on its ...surface ligand DEC-205, we show that targeted nanoparticles encapsulating a MART-1 27–35 peptide are both internalized and cross-presented with significantly higher ...
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Agarwal, Noopur (2009): Role of MeCP2 in heterochromatin organization during differentiation and disease. Dissertation, LMU München: Fakultät für Biologie
... the ligand is lost. In this study we showed that small peptide fragments can by-pass this mechanism in a catalytic ...the ligand exchange. Peptide-MLE were able to increase not only the ...
128
Ultrasmall AGuIX theranostic nanoparticles for vascular-targeted interstitial photodynamic therapy of glioblastoma
... new ligand peptide motif (KDKPPR) targeting neuropilin-1 (NRP-1), a receptor overexpressed by angio- genic endothelial cells of the tumor ...the peptide affinity for NRP-1 recombinant protein were ...
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Monocyte galactose/N-acetylgalactosamine-specific C-type lectin receptor stimulant immunotherapy of an experimental glioma. Part 1: stimulatory effects on blood monocytes and monocyte-derived cells of the brain
... The use of GCLRP in this study has shown that in rela- tionship to the geography of the tumor, there are regionally relevant and unique behaviors associated with the varying subpopulations of MDCBs that influenced the ...
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Ghrelin, motilin in health and disease
... signaling peptide produced mainly by the stomach [1] but also in smaller quantities by other ...natural ligand for the growth hor- mone secretagogue receptor, GHSR-1a [2], now recog- nized widely as the ...
197
A TNF receptor loop peptide mimic blocks RANK ligand–induced signaling, bone resorption, and bone loss
... WP9QY is predicted to bind to RANKL and alter the conformation of the RANKL-RANK complex. (A) Comparison of the sequence of peptide WP9QY with the corresponding sequences of domain 3 of TNFR(I), RANK, OPG, CD40, ...
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Vascular targeted nanotherapeutic approach for obesity treatment
... iRGD peptide is further cleaved into the CRGDK fragment which then binds to neuropilin-1; CRGDK increases uptake and internalization of the drug-loaded NPs into the local ...
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