peptide vaccine
Multiepitope CD8+ T cell response to a NY ESO 1 peptide vaccine results in imprecise tumor targeting
... NY-ESO-1 peptide vaccine composed of the two previously defined peptides 157-165 and 157-167, administered with GM-CSF as a systemic ...NY-ESO-1 peptide vaccine elicited a CD8 + T cell ...
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Anti-metastatic effect of the TM4SF5-specific peptide vaccine and humanized monoclonal antibody on colon cancer in a mouse lung metastasis model
... TM4SF5-specific peptide vaccine and monoclonal antibody in HCC and colon cancer in a mouse ...cyclic peptide targeting TM4SF5. Cyclic peptide-specific antibodies were produced in mice after ...
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Recombinant heat shock protein 70 functional peptide and alpha-fetoprotein epitope peptide vaccine elicits specific anti- tumor immunity
... therapeutic peptide vaccine by linking heat shock protein 70 (HSP70) functional peptide to the AFP epitope to obtain ...novel peptide was administered into BALB/c mice to observe the ...
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Design of an epitope-based peptide vaccine against spike protein of human coronavirus: an in silico approach
... epitope-based vaccine designed for ...multiepitope vaccine candidate against this virus that could be suitable to trigger a significant immune ...The peptide sequence from 88–94 amino acids and the ...
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A Review on Role of Peptide Vaccines in Cancer Therapy Treatment of Cancer Disease by Peptide Vaccine
... Amino acid sequences (peptide) are the building block for peptide vaccine. Antigen stimulates the immune response by recognizing the tumor cell. Epitope based peptide vaccines are upgraded and ...
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Computational Design of Peptide Vaccine against Acinetobacter Baumannii Infection using Comparative Genomic Approach
... no vaccine or specific drug available for its treatment, this necessitate the need for the identification of therapeutic target enzyme and ...and peptide-vaccine candidates in the pathogen. ...
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Design of an Epitope-Based Synthetic Long Peptide Vaccine to Counteract the Novel China Coronavirus (2019-nCoV)
... potential peptide vaccine candidates takes a community- level personalized strategy, that we refer to as populationalized vaccinomics, which enables the design of peptides based on the genome sequence of ...
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Peptide vaccine immunotherapy biomarkers and response patterns in pediatric gliomas
... To identify biomarkers of response and peripheral immunoreactivity patterns, we performed RNA sequencing (RNA-seq) on peripheral blood mononuclear cells (PBMCs) from patients prior to the start of vaccine ...
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The Telomerase-Derived Anticancer Peptide Vaccine GV1001 as an Extracellular Heat Shock Protein-Mediated Cell-Penetrating Peptide
... a peptide derived from a reverse-transcriptase subunit of telomerase (hTERT) and developed as a vaccine against various cancers, reportedly has unexpected CPP ...TAT peptide, GV1001 enabled the ...
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Immunization with a HER 2/neu helper peptide vaccine generates HER 2/neu CD8 T cell immunity in cancer patients
... HER-2/neu peptide–based vaccine trial approved by the University of Washington’s Human Subjects Division and the United States Food and Drug ...each peptide (1.5 µg total peptide dose) were ...
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Delineating Blueprint of an Epitope-based Peptide Vaccine against the
... The final target protein was selected based on the assessment of proteins antigenicity, subcellular.. 81.[r] ...
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Clinical Development of PD-1/PD-L1 Immunotherapy for Gastrointestinal Cancers: Facts and Hopes.
... Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open- label, ran[r] ...
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Therapeutic cancer vaccines and combination immunotherapies involving vaccination
... combinatorial vaccine therapy will likely need to address three goals: building a robust antigen- specific CTL response; altering the tumor microenvironment to allow CTL infiltration and reduce migration of ...
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ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)
... cancer vaccine, immune checkpoint inhibitors) remains optimistic ...or peptide vaccines that mimic antigen ...cell vaccine trial (allogenic DFT1 cell line) are eagerly awaited (http:// ...cell ...
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iNKT/CD1d-antitumor immunotherapy significantly increases the efficacy of therapeutic CpG/peptide-based cancer vaccine
... the vaccine formulation, and in particular the presence of the Toll-like Receptor (TLR) agonist CpG, can significantly promote the maturation of pro-inflammatory DCs, which favors Type I T cell responses while ...
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In silico-based vaccine design against Ebola virus glycoprotein
... definite vaccine or other remedial agents have been developed yet for the management and avoidance of EBOV infections in ...epitope-based peptide vaccine against EBOV, using a combination of B-cell ...
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A randomized pilot phase I study of modified carcinoembryonic antigen (CEA) peptide (CAP1-6D)/montanide/GM-CSF-vaccine in patients with pancreatic adenocarcinoma
... optimal vaccine adjuvant for peptide vaccines, and fur- ther improvements in the vaccine formulation are con- ...diminished peptide-induced T cell responses in a melanoma vaccine study ...
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Potential Coverage of the 4CMenB Vaccine against Invasive Serogroup B Neisseria meningitidis Isolated from 2009 to 2013 in the Republic of Ireland
... conjugate vaccine immunogenicity is assessed by the serum bactericidal antibody (SBA) assay, which measures complement- mediated killing for representative strains expressing different serogroups ...their ...
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Similar Epitope Specificities of IgG and IgA Antibodies Elicited by Ad26 Vector Prime, Env Protein Boost Immunizations in Rhesus Monkeys
... ALVAC/gp120 vaccine would be relevant for an Ad26/gp140 ...high-throughput peptide microarray as a tool to study vaccine-elicited IgA antibody responses in greater detail, with the limitation that ...
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The Signal Peptide Sequence Impacts the Immune Response Elicited by a DNA Epitope Vaccine
... (S). The plasmid also contains a T H epitope, ovalbumin (OVA) (323–339) (O), which is targeted to the MHC II bind- ing pathway by the dileucine lysosomal targeting motif (LL) (36). The second plasmid, RAOLL, is identical ...
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