Peptide vaccines
Multiple therapeutic peptide vaccines consisting of combined novel cancer testis antigens and anti angiogenic peptides for patients with non small cell lung cancer
... Peptide vaccines used in this trial included peptides that originated from VEGFR1 and VEGFR2 for targeting angiogenesis in tumors. Bevacizmab, an antibody targeting VEGF, has already been used to treat the ...
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A Review on Role of Peptide Vaccines in Cancer Therapy Treatment of Cancer Disease by Peptide Vaccine
... A peptide vaccine provides several advantages in comparison to conventional ...vaccines. Vaccines of peptide are a safe and economical technology compared to traditional vaccines made ...
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Getting peptide vaccines to work: just a matter of quality control?
... that vaccines consisting of aseptic, endotoxin-free peptides are likely to be ignored and will likely be ineffective at inducing T cell immuni- ...thetic peptide vaccines has been the use of ...
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Approaches to Improve Chemically Defined Synthetic Peptide Vaccines
... in peptide-based vaccinations to induce T-cell-dependent immune responses against cancer has invigorated the search for optimal vaccine ...of peptide-based vaccines like peptide- adjuvant ...
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ANTIGENIC DETERMINANTS OF NEUROTOXIN FROM Mesobuthus Tamulus : NEW APPROACH FOR SYNTHETIC PEPTIDE VACCINES
... The peptide vaccines concept is based on identification and chemical synthesis of B-cell and T-cell epitopes which are immunodominant and can induce specific immune ...effective peptide ...
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Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro.
... synthetic peptide vaccines, we used recombinant DNA techniques to generate chimeras between immunogenic determinants of human immunodeficiency virus type 1 (HIV-1) gp120 and antibody Fab fragments reactive ...
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Peptide crosslinked micelles: a new strategy for the design and synthesis of peptide vaccines
... multicomponent peptide vaccines, named the peptide crosslinked micelles ...deliver peptide antigens and immunostimulatory DNA to antigen-presenting cells ...DNA, peptide antigen, and a ...
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ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1)
... cancer vaccines as prospective ...delivery vaccines that utilise inactivated cancer cells (autologous or allogenic) or peptide vaccines that mimic antigen ...a peptide vaccine, where ...
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Adjuvants for peptide-based cancer vaccines
... experimental peptide and protein-based cancer vac- cines ...IFA-based peptide vaccines can induce potent cytotoxic CD8 T cell responses in mice, followed by T cell retention, exhaustion and deletion ...
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Vaccine Delivery Methods into the Future
... Synthetic peptide chemistry has greatly contributed to vaccinology, where peptides (2–100 amino acids) could be synthesized and used as immunogens, in addition to synthesizing T and B cell epitopes and used as ...
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An Albumin-binding Polypeptide Both Targets Cytotoxic T Lymphocyte Vaccines to Lymph Nodes and Boosts Vaccine Presentation by Dendritic Cells
... of vaccines, whether they are from self-antigens or ...free peptide vaccines and peptide vaccines delivered by an albumin-binding, micellar carrier ...compared vaccines are ...
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The Use of Analgesics during Vaccination with a Live Attenuated Yersinia pestis Vaccine Alters the Resulting Immune Response in Mice
... these vaccines and animal models must be well-characterized in the absence of analgesics initially, and the analgesics should be shown to offer measurable benefit to the animals with regard to the alleviation of ...
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E ect of Di erent Adjuvants on the Longevity and Strength of Humoral and Cellular Immune Responses to the HCV Envelope Glycoproteins
... formulations were able to induce antigen-specific CD8 T cells as the cytokine secretion in response to the E1/E2 peptide pool was restricted to T cells of the CD4 phenotype. This was not unexpected, as previous ...
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Simultaneous Deletion of Virulence Factors and Insertion of Antigens into the Infectious Laryngotracheitis Virus Using NHEJ-CRISPR Cas9 and Cre–Lox System for Construction of a Stable Vaccine Vector
... Abstract: Infectious laryngotracheitis virus (ILTV) is a promising vaccine vector due to its heterologous gene accommodation capabilities, low pathogenicity, and potential to induce cellular and humoral arms of immunity. ...
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Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination
... We used this tool to investigated adverse events following Yellow fever vaccination, after a mass vaccine campaign in Minas Gerais.. We solved 17 suspected adverse events following YF va[r] ...
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Anti-Idiotype Vaccine Provides Protective Immunity Against Vibrio Harveyi in Grouper Epinephelus Coioides
... [16,17]. Vaccines based on anti-Id Abs have been so far applied in the control of numerous pathogenic diseases [16,17] and cancers ...fish vaccines. To our knowledge, only two studies on fish anti-Id ...
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Parenteral–Oral Immunization with Plant-Derived HBcAg as a Potential Therapeutic Vaccine against Chronic Hepatitis B
... HBcAg is produced in well-established standard expression systems such as bacteria, yeasts, and mammalian cells. Then, it is delivered mostly via parenteral or intranasal routes; thus, it has to be purified and delivered ...
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An MVA Vector Expressing HIV-1 Envelope under the Control of a Potent Vaccinia Virus Promoter as a Promising Strategy in HIV AIDS Vaccine Design
... FCS and stimulated with 5 µ g/mL of Env peptide pools and 0.5 µ g/mL of HIV-1 gp120 envelope protein from isolate BX08 (CNB) along with anti-CD154 (CD40L)-PE antibody at 37 ◦ C. Two hours later, 1 µL/mL protein ...
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Therapeutic Vaccine in Chronically HIV-1-Infected Patients: A Randomized, Double-Blind, Placebo-Controlled Phase IIa Trial with HTI-TriMix
... The vaccine was shown to be safe and well tolerated as no serious unforeseen safety issues occurred and vaccine related side-effects were short-lived. Unfortunately, after completion of this clinical trial, a coding ...
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Assessing Vaccine Hesitancy among Healthcare Workers: A Cross-Sectional Study at an Italian Paediatric Hospital and the Development of a Healthcare Worker’s Vaccination Compliance Index
... This survey shows that vaccine hesitancy issues exist and are relevant in the investigated hospital, with substantial differences between departments and professional classes. The departments most affected by this ...
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