perineural invasion
Upregulated matrix metalloproteinase-2 and downregulated tissue factor pathway inhibitor-2 are risk factors for lymph node metastasis and perineural invasion in pancreatic carcinoma
... Background: Dysregulated expression of matrix metalloproteinase (MMP)-2 and tissue factor pathway inhibitor (TFPI)-2 is closely associated with tumorigenesis and tumor progression. The aim of this work was to determine ...
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Treatment Recommendations among Radiation Oncologists in the Treatment of Cutaneous Squamous Cell Carcinoma with Perineural Invasion
... margins. Perineural invasion (PNI), tumor diameter (>2 cm), deep invasion, poorly differentiated histology, and immunosuppression have been identified as negative prognostic factors for CSCC, and ...
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M3 muscarinic acetylcholine receptors regulate epithelial–mesenchymal transition, perineural invasion, and migration/metastasis in cholangiocarcinoma through the AKT pathway
... perineural invasion, such as cholangiocarcinoma [25– 27]. In fact, abnormal neurotransmitter expression and/ or receptor signaling in tumors greatly affects tumor proliferation, differentiation, and ...
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Original Article miR-21 targets MMP-7 and promotes perineural invasion of cholangiocarcinoma
... Objective: Perineural invasion (PNI) is a form of cholangiocarcinoma (CC) ...and invasion by its various targets in many cancer ...promoted invasion and PNI of CC cells and explored its ...
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Original Article The status of perineural invasion predicts the outcomes of postoperative radiotherapy in locally advanced esophageal squamous cell carcinoma
... Abstract: Background: Prognosis of locally advanced esophageal squamous cell carcinoma (ESCC) remains dismal even after curative resection and adjuvant radiotherapy. New biomarkers for predicting prognosis and treatment ...
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Perineural invasion in endometriotic lesions contributes to endometriosis-associated pain
... Patients and methods: The study was conducted in the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Sun Yat-sen University from June 2012 to Janu- ary 2015. In total, 64 patients with DIE ...
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Original Article Expression of c-Myc and Fas correlates with perineural invasion of pancreatic cancer
... Abstract: Lymph node metastasis (LNM) and perineural invasion (PNI) are regarded as two important prognostic fac- tors in pancreatic cancer. The aim of this study was to identify the LNM-associated and ...
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Perineural invasion correlates with postoperative distant metastasis and poor overall survival in patients with <sub>P</sub>T<sub>1–3</sub>N<sub>0</sub>M<sub>0</sub> esophageal squamous cell carcinoma
... Perineural invasion (PNI) is a pathological process characterized by cancer cells surrounding nerve fibers and entering the perineurium or neural ...
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<p>Weighted Gene Co-Expression Network Analysis Identified Cancer Cell Proliferation as a Common Phenomenon During Perineural Invasion</p>
... Purpose: Perineural invasion (PNI) is the neoplastic invasion of nerves by cancer cells, a process that may prove to be another metastatic route besides direct invasion, lymphatic spread, and ...
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Gene Expression Analysis of the Concomitant Existence of Lymphovascular and Perineural Invasion in Colorectal Cancer
... For the downregulated genes in LVI-PNI+ group, the three most significant ones are FGF20, IGFBPL1 and IGFL4. FGF20, also known as fibroblast growth factor 20, is part of the fibroblast growth factor (FGF) family (65). In ...
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Perineural invasion as an independent predictor of biochemical recurrence in prostate cancer following radical prostatectomy or radiotherapy: a systematic review and meta-analysis
... According to the PRISMA guidelines [9], a systematic literature search of the PubMed, EMBASE, Chinese Na- tional Knowledge Infrastructure (CNKI) and Wan Fang databases was performed (up to May 2017). The search strategy ...
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Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer
... Perineural invasion (PNI) is considered as an alternative route for the metastatic spread of pancreatic cancer cells; however, the molecular changes leading to PNI are still poorly ...cells invasion ...
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Current research in perineural invasion of cholangiocarcinoma
... nervous invasion and metastasis using computer-assisted three- dimensional (3D) ...tumor perineural invasion is actually a type of tumor local growth ...The perineural interspace ...
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Indications for extrahepatic bile duct resection due to perineural invasion in patients with gallbladder cancer
... hand, perineural invasion (PNI) was reported as an important factor in patients with gallbladder cancer because gallbladder cancer cells frequently spread to the tissues surrounding the EHBD via ...
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Original Article Cytoplasmic HSP90α expression is associated with perineural invasion in pancreatic cancer
... Abstract: Pancreatic cancer (PC) is an aggressive and devastating disease with a dismal prognosis. The study aimed to investigate the role of HSP90α and PDIA3 in patients with PC. Immunohistochemistry was performed on ...
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Original Article The significance of perineural invasion as a prognostic factor in cervical cancer patients of different ethnicities
... of perineural invasion (PNI) in cervical cancer has been previously investigated with no consistent ...parametrial invasion and lymphovascular space invasion were closely associated with the ...
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<p>Prognostic significance of perineural invasion in vulvar squamous cell carcinoma</p>
... radiotherapy after surgery. Radiotherapy was recom- mended for patients with tumour-positive margins or close surgical margins (de fi ned as tumour-free margin <8 mm based on histology) at the primary tumor site, and ...
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<p>Sympathetic innervation contributes to perineural invasion of salivary adenoid cystic carcinoma via the β2-adrenergic receptor</p>
... were added onto the Matrigel (BD Biosciences, Franklin Lakes, NJ, USA)-covered inserts in 200 μ L serum-free RPMI 1640 media. The lower chamber was seeded with two DRG explants from a newborn Sprague-Dawley rat in 600 μ ...
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Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer
... Exogenous CXCL12 can enhance PC3 cells' ability to pen- etrate ECM gel. Initially in this process, chemokines com- bining with their receptors cause actin to concentrate and enhance cell mobility. Muller [20] reported ...
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MMP1/PAR1/SP/NK1R paracrine loop modulates early perineural invasion of pancreatic cancer cells
... exhibited invasion with the left side being more apparent than the right ...cell invasion along the nerves extending from the left sciatic nerve injection area to the spine nerve ...Nerve invasion ...
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