perinuclear region
Actin-Modulating Protein Cofilin Is Involved in the Formation of Measles Virus Ribonucleoprotein Complex at the Perinuclear Region
... Phosphorylation is required for cofilin to interact with the MV N protein. The ability of cofilin to modulate reorganization of the actin cytoskeleton is regulated by the phosphorylation of its serine residue at position ...
8
Hantavirus Nucleocapsid Protein Is Expressed as a Membrane-Associated Protein in the Perinuclear Region
... We have demonstrated that NBCCV is expressed as a pe- ripheral membrane-associated protein in the perinuclear re- gion. The evidence that supports this conclusion is presented at both the cellular and biochemical ...
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Complex Formation of RNA Silencing Proteins in the Perinuclear Region of Neurospora crassa
... the perinuclear region (the “sur- veillance checkpoint”) during prophase I of ...the perinuclear region in germ cells contains an organelle known as chroma- toid body in mammals, nuage in ...
5
The Human Papillomavirus Type 16 E5 Oncoprotein Translocates Calpactin I to the Perinuclear Region
... a perinuclear redistribution of annexin A2 and p11 and show increased fusion of perinuclear membrane ...the perinuclear redistribution of calpactin I and increased formation of perinuclear ...
8
Beta, Beta'-Iminodipropionitrile-Induce Movement of Vimentin Intermediate Filaments to the Perinuclear Region is Insufficient to Inhibit cPLA2 Activity.
... inhibits lysyl oxidase (47). The precise mechanism by which IDPN inhibits vimentin is unknown, but its effects on vimentin have been studied (46-48). In addition, the effects of IDPN are considered selective for ...
46
Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcription.
... inactivation of required checkpoints in the cell cycle, giving rise to uncontrolled cellular DNA replication and transformation. In the present study, the mtrII oncoprotein was detected in HCMV-infected cells and in both ...
10
Direct Binding of Human Immunodeficiency Virus Type 1 Nef to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail Disrupts MHC-I Trafficking
... FIG. 1. HIV-1 Nef-DsRed fusion protein causes reduction of cell surface MHC-I antigens, and colocalizes with MHC-I in the perinuclear area. (A and B) Nef-DsRed fusion protein downmodulates MHC-I. HeLa cells stably ...
12
Near-infrared quantum dots for HER2 localization and imaging of cancer cells
... as well. Previous studies have demonstrated a complete out- line of the cells because the QD-antibody conjugate attaches to the extracellular receptors. However, most of these studies used QD-based immunohistochemistry ...
15
Dynein-Dependent Transport of the Hantaan Virus Nucleocapsid Protein to the Endoplasmic Reticulum-Golgi Intermediate Compartment
... the perinuclear region, and based on early electron microscopy work, it has been assumed that hantaviral N targets the Golgi body (29, 31, 38, 54, ...ERGIC region and not the Golgi ...this ...
14
Adenovirus Triggers Reorganization of Vimentin-Containing Intermediate Filaments Resulting in the Perinuclear Movement of cPLA2 and Suppression of Prostaglandin Production
... C3HA cells are a well characterized murine 3T3-like fibroblast cell line that have been used extensively to study the effects of Ad on host cellular function (46, 48-50). Moreover, because these cells are murine in ...
173
Impact on the Endoplasmic Reticulum and Golgi Apparatus of Turnip Mosaic Virus Infection
... the perinuclear region has been reported for a few plant viruses (2, 11, 35, 45, ...a perinuclear viral com- partment where replication took ...the perinuclear structure is a major site for ...
11
Intracellular aggregated TRPV1 is associated with lower survival in breast cancer patients
... We utilized two fluorescent probes for detection of endo- plasmic reticulum and Golgi complex and examined the colocalization with the channel signal applying an automated procedure (Figure 1B). The colocalization ...
8
Biochemical and Functional Characterization of the Ebola Virus VP24 Protein: Implications for a Role in Virus Assembly and Budding
... and perinuclear region in both transfected and Ebola virus-infected cells, (ii) VP24 associates strongly with lipid membranes, (iii) VP24 does not contain N-linked sugars when expressed alone in mammalian ...
8
Fast perinuclear clustering of mitochondria in oxidatively stressed human choriocarcinoma cells
... abnormal, perinuclear clustering of mitochondria from an evenly spread distribution throughout the ...asymmetric perinuclear clustered ...asymmetrical perinuclear clustered distribution of the ...the ...
6
Phosphatidylinositol 3-Kinase-, Actin-, and Microtubule-Dependent Transport of Semliki Forest Virus Replication Complexes from the Plasma Membrane to Modified Lysosomes
... (p.i.). After fixation, cells were coimmunolabeled with poly- clonal antibodies raised against each of the four nsPs (nsP1 to nsP4) and a monoclonal antibody against dsRNA. The pres- ence of dsRNA molecules in infected ...
15
Trapping of normal EB1 ligands in aggresomes formed by an EB1 deletion mutant
... the region that mediates the interactions with APC and p150glued ...the perinuclear EB1-∆N2-GFP aggregates might represent a structure unrelated to aggresomes and instead arise from dominant-negative ...
15
Herpes Simplex Virus Type 1 UL51 Protein Is Involved in Maturation and Egress of Virus Particles
... Construction of the recombinant viruses. The mutagenesis procedure was performed as previously described (48), with slight modifications for alteration of the UL51 coding region in pYEbac102. Briefly, linear ...
10
Sodium arsenite induced histochemical changes in the liver of fish Mystus bleekeri (Day)
... In the liver cells of normal (control) fish, Mystus bleekeri (plate 1, Fig. 01) were characterized by high concentration of proteins are visualized as intensely dark blue coloured granules. The normal hepatocytes ...
5
Herpes Simplex Virus 1 Envelopment Follows Two Diverse Pathways
... gain access to the cytoplasm. It was suggested, though never shown, that virions are released from the perinuclear space by vesicle formation (4, 6, 9, 15, 45, 56). Alternatively, virions of many members of the ...
13
Electron Tomography of Nascent Herpes Simplex Virus Virions
... One argument supporting the possibility that the original virion envelope is maintained throughout virion egress has been the longstanding observation that perinuclear virions can be observed within cytoplasmic ...
10