Peripheral insulin resistance
Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes
... Our results show that partial dysregulation of Irs2 signaling in β cells and brain — including the hypothalamus — may explain the close association between obesity, peripheral insulin resistance, and ...
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PHARMACOTHERAPY OF DPP4 INHIBITORS IN THE MANAGEMENT OF DIABETES MELLITUS
... enough insulin. Type 2 DM begins with insulin resistance, a condition in which cells fail to respond to insulin ...causes peripheral insulin resistance means that although ...
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Dietary fatty acid composition alters 11β-hydroxysteroid dehydrogenase type 1 gene expression in rat retroperitoneal white adipose tissue
... increased peripheral insulin resistance compared to PUFA rich diet- fed ...or insulin resistance parameters of these two ...and insulin resistance [6-10] and also provides ...
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Role of the forkhead protein FoxO1 in β cell compensation to insulin resistance
... to peripheral insulin resistance (Insulin receptor transgenic knockouts) and 1 due to ectopic local expression of IGF2 (Elastase- IGF2 transgenics), without affecting insulin ...to ...
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Neurohumoral stimulation in type-2-diabetes as an emerging disease concept
... of peripheral insulin resistance and overall oxidative stress in T2D represent known activators of the sympathetic component of the autonomic nervous ...cause peripheral insulin ...
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Intracellular lipid metabolism impairs β cell compensation during diet induced obesity
... of insulin-producing b cells is critical to maintaining glucose homeostasis at the early stage of type 2 ...and insulin dependence in ...and peripheral insulin resistance, we eliminated ...
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Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes
... and insulin resistance associated with secondary pancreatic b cell failure, leading to ...and insulin resistance in female WT ...produces insulin hypersecretion in response to glucose ...
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TREATMENT OF HIV- INFECTED DIABETIC PATIENTS
... inhibited insulin-stimulated, GLUT4-mediated glucose uptake by adipocytes (16, ...induced peripheral insulin resistance and impaired glucose-stimulated insulin secretion from beta cells ...
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Special issue: Molecular mechanisms of insulin resistance in peripheral tissues Metabolic and molecular mechanisms of macrophage polarisation and adipose tissue insulin resistance
... by peripheral insulin resistance and systemic ...all peripheral tissues, including ...of insulin resistance, locally and ...and insulin resistance in ...in ...
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The interrelationship between insulin resistane and Alzheimer development
... (a) Peripheral IR results in periods of hyperinsulinemia to overcome the hyperglycemia; (b) Hyperinsulinemia, with the possible contribution of central insulin resistance, leads to increased ...
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CXC Ligand 5 cytokine serum level in women with polycystic ovary syndrome and normal body mass index: A case-control study
... serum insulin, LH, and LH/FSH ...and insulin increase production of ovarian androgens synergistically ...(24). Insulin resistance stimulates insulin release, reduces sex hormone-binding ...
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A Clinical Study on Gestational Diabetes Mellitus and Pregnancy Induced Hypertension.
... of insulin, risk of overt diabetes mellitus and neonatal hypoglycemia were higher with women diagnosed GDM early than women with GDM diagnosed ...and insulin treatment, study also concluded higher incidence ...
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Differential role of insulin resistance and β-cell function in the development of prediabetes and diabetes in middle-aged and elderly Chinese population
... Insulin resistance is a well-established major cause for abnormal glucose ...increased insulin resistance in impaired glucose tolerance (IGT) and T2DM patients [19, ...for insulin ...
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“APPROACH TO POSTMENOPAUSAL CARDIOVASCULAR RISK” by *Pradeep Kumar Dabla, Vandana Dabla, Rajni Dawar, Sarika Arora, India.
... is insulin resistance. Insulin resistance, with inadequate compensatory hyperinsulinemia, diminishes the normal suppression of FFA arising from adipose tissue by ...impair peripheral ...
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A survey of metabolic syndrome in first-degree relatives (fathers) of patients with polycystic ovarian syndrome
... quantitative insulin sensitivity check and homeostasis model insulin resistance indices, the prevalence of insulin resistance, hypertension, type 2 diabetes and hypercholesterolaemia ...
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Insulin resistance is significantly associated with the metabolic syndrome, but not with sonographically proven peripheral arterial disease
... Differences in patient characteristics were tested for statis- tical significance with the Chi square test for categorical variables; the Mann–Whitney–U and Kruskal–Wallis tests were used for continuous variables, as ...
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AUSTRALIAN JOURNAL OF BASIC AND
... Diabetes, a condition in which the body has lost the ability to produce, or to correctly utilize insulin, is the eighth-leading cause of death by disease in the world. In 2013, according to the International ...
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Review on Diabetes Mellitus
... (Non- Insulin-dependent) diabetes mellitus, and within this category no more than 10% can be accounted for monogenic forms such as maturity-onset diabetes of the young and mitochondrial diabetes or late-onset ...
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Adipokines and Insulin Resistance
... Adiponectin’s effects on glucose me- tabolism are mediated through two dis- tinct receptors termed adiponectin recep- tor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2). AdipoR1 is expressed ubiq- uitously, whereas ...
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Insulin Resistance Study in Diabetes Mellitus Type II and Its Correlation with Obesity
... and insulin levels, we took 5 ml venous blood samples were drawn from ante-cubital vein using aseptic measures in 5cc disposable syringes without any anticoagulant in the morning after an overnight fast of 10-12 ...
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