PERK signaling
Uncovering Dual Roles for PERK Signaling During Experimentally Induced Pancreatitis
... that PERK activation under these conditions does not lead to Stc2 ...of PERK signaling. Our laboratory has shown that PERK activity increases during pancreatic injury (Kowalik et ...of ...
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IMB-6G, a novel N-substituted sophoridinic acid derivative, induces endoplasmic reticulum stress-mediated apoptosis via activation of IRE1α and PERK signaling
... Activation of CHOP downstream of PERK signaling plays an important role in executing ER stress-induced apoptosis in diverse types of cells [6]. In line with this, our results showed IMB-6G induced an ...
14
ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling
... Many studies reported that a variety of physical and chemical factors can turn on ER stress and influence cell survival in chondrocyte differentiation, chondro- genesis and endochondral ossification [18–20]. ER ...
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Inhibition of PERK Signaling Prevents Against Glucocorticoid-induced Endotheliocyte Apoptosis and Osteonecrosis of the Femoral Head
... ECs were treated with DEX under different conditions. The cells were harvested and lysed with cell lysis buffer supplemented with protease and phosphatase inhibitor cocktails (Sigma-Aldrich, St. Louis, MO) on ice for 15 ...
10
PERK Signaling Pathway Involved in Lactic Acid Induced Astrocyte Damage
... At 24 h following Lactic acid treatment, the cells were detached using trypsin, lysed using cell lysis buffer (Life Technologies) and then centrifuged at 3,000 g for 15 min at 37C. The pellet was collected, sonicated, ...
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A Chemical-Genetic Screen for Identifying Substrates of the Er Kinase Perk
... to PERK signaling, only one screen has thus far been performed for substrate identification (Cullinan et al, 2003), with just three direct PERK substrates identified to date: the translation ...
101
<p>The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy</p>
... Autophagy is the self-phagocytosis of cells, which is an important degradation mechanism that eliminates damaged organelles and harmful substances in the lysosome. 2 A study found that the progression of DN was ...
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Expression patterns of STAT3, ERK and estrogen-receptor α are associated with development and histologic severity of hepatic steatosis: a retrospective study
... both pERK in hepatic stellate cells and estrogen-receptor α in hepatocytes may be linked to the development of hepatic ...steatosis. pERK was expressed in hepatic stellate cells in all hepatic steatosis ...
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Original Article Upregulation of autophagy genes and the unfolded protein response in human heart failure
... protein levels along with increased mRNA of proteins involved in IRE-1 (increased Cebpa) and CHOP (Chop, Atf3) in heart failure patients (n=3) [15]. Given the close relationship between arrhythmias and the UPR, we ...
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The Unfolded Protein Response and Autophagy: Herpesviruses Rule!
... The UPR is induced when the ER responds to an overload of unfolded proteins. For example, malfolded forms of influ- enza virus hemagglutinin induce increased synthesis of the immunoglobulin heavy chain-binding protein, a ...
5
Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats
... In this study, no toxic or side effects of EMO were ob- served on treated rats. It has been known that EMO has anti-inflammatory [27] and anti-tumor effects [28]. However, emodin could also lead to hepatotoxicity, kid- ...
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PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death
... activated PERK and up-regulated its downstream target CHOP in a dose dependent manner (Figure ...the PERK/ CHOP signaling ...the PERK/CHOP signaling ...
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Upregulation of CHOP/GADD153 during Coronavirus Infectious Bronchitis Virus Infection Modulates Apoptosis by Restricting Activation of the Extracellular Signal-Regulated Kinase Pathway
... total PERK, PKR, p-eIF2 ␣ (Ser51), GADD153, ERO1 ␣ , poly(ADP-ri- bose) polymerase (PARP), Bcl2, p-ERK1/2, ERK1/2,  -actin, and  -tu- bulin were purchased from Cell Signaling ...
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Original Article miR-222 enhances radiosensitivity of cancer cells by inhibiting the expression of CD47
... a signaling receptor for thrombospon- din-1 and has been found to be expressed in multiple human tumor types, while it is ubiqui- tously expressed at low levels in normal cells [25, ...CD47 signaling ...
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Analysis of growth factor signaling in genetically diverse breast cancer lines
... Other ligands to which breast cancer cells commonly respond include FGFs, IGF/INS, and HGF. Responsive- ness to SCF and PDGF is observed more sporadically, but can be as strong as responses to ErbB ligands when the ...
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Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress
... Inhibition of ER stress reversed progranulin-induced oxidative stress response and increased autophagy, preventing from insulin resistance in adipocytes In addition, the ER stress specific inhibitor 4-PBA was used to ...
8
Influence of Experience on Users’ Behaviour: A Day-to-Day Model for Route Choice Updating
... of pERK following the application of a number of acute noxious stimuli including electrical, thermal, mechanical, and chemical stimulation (mustard oil, capsaicin, and carrageenan) (Ji et ...of ...
14
Chinese herb pair Paeoniae Radix Alba and Atractylodis Macrocephalae Rhizoma suppresses LPS-induced inflammatory response through inhibiting MAPK and NF-κB pathway
... The excessive pro-inflammatory mediators are mainly caused by activated transcriptional factors in the devel- opment of inflammation progress, among these regula- tions, NF-κB play an important role in macrophages [38]. ...
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The PERK inhibitor GSK2606414 enhances reovirus infection in head and neck squamous cell carcinoma via an ATF4-dependent mechanism
... The PERK inhibitor GSK2606414 enhances reovirus infection in head and neck squamous cell carcinoma via an ATF4-dependent mechanism, Molecular Therapy: Oncolytics (2020), doi: ...
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ERK signaling is required for eye specific retino geniculate segregation
... after pERK blockade, are very similar to the alterations due to electrical activity ...Indeed, pERK blockade in dLGN by ICV U0126 treatment ...of pERK (see Table 1 and ...
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