permeability transition pore
Regulation of mitochondrial permeability transition pore by PINK1
... mitochondrial permeability transition pore (mPTP) is increased in PINK1 − / − cells, and this genotypic difference between PINK1 − / − and control cells is eliminated by agonists or inhibitors of the ...
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a-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
... cells with oligomers, in some neurons, induced a sudden drop in mitochondrial NADH, which could be induced by rapid activation of NADH consumption due to uncoupling of mitochondria or by mitochondrial permeability ...
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Hepatitis B Virus X Protein Modulates Apoptosis in Primary Rat Hepatocytes by Regulating both NF-κB and the Mitochondrial Permeability Transition Pore
... The hepatitis B virus (HBV) X protein (HBx) is a multifunctional protein that regulates numerous cellular signal transduction pathways, including those that modulate apoptosis. However, different HBx-dependent effects on ...
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Circular RNA CircEZH2 Suppresses Transmissible Gastroenteritis Coronavirus-induced Opening of Mitochondrial Permeability Transition Pore via Targeting MiR-22 in IPEC-J2
... Transmissible gastroenteritis (TGE) is a contagious and infectious disease that is characterized by severe vomiting and diarrhea of swine , especially piglet, and caused by transmissible gastroenteritis coronavirus ...
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Original Article Effects of hydromorphone postconditioning on ischemia-reperfusion injury in isolated rat hearts and mitochondial permeability transition pore
... Abstract: To investigate the effects of hydromorphone postconditioning on ischemia/reperfusion injury in isolated rat hearts and mitochondial permeability transition pore (mPTP). Male SD rat hearts ...
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Ubisol-Q10 Prevents Glutamate-Induced Cell Death by Blocking Mitochondrial Fragmentation and Permeability Transition Pore Opening
... Mitochondrial dysfunction and oxidative stress are the major events that lead to the formation of mitochondrial permeability transition pore (mPTP) during glutamate-induced cytotoxicity and cell ...
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Glycogen synthase kinase 3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
... the permeability transition pore complex (specifically, adenine nucleotide translocator and voltage-depen- dent anion channel [Figure 8C], as well as hexokinase and creatine kinase [not shown]) given ...
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The effect of permeability transition pore opening on reactive oxygen species production in rat brain mitochondria
... изучено влияние открытия митохон- дриальной поры (mitochondrial permeability transition pore (MPTP) на продукцию активных форм кислорода (аФК) в митохондриях мозга крыс. показано, что в зависимости ...
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Modulation of Mitochondrial Permeability Transition Pore Affects Multidrug Resistance in Human Hepatocellular Carcinoma Cells
... Mitochondrial permeability transition (mPT) is implicated as an important event in the control of cell death or survival and mPT represents a target for the development of cytotoxic ...mitochondrial ...
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Vaccinia Virus Infection Disarms the Mitochondrion-Mediated Pathway of the Apoptotic Cascade by Modulating the Permeability Transition Pore
... multimeric permeability transition pore complex, was prevented in vaccinia virus-infected ...ability transition pore following treatment with the permeability transition ...
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ACTIVITY OF APIGENIN AND QUERCETIN ON RAT HEPATIC MITOCHONDRIAL PERMEABILITY TRANSITION PORE
... calcium-induced permeability transition in normal rat ...the pore in a concentration dependent manner in the absence of Ca 2+ ...membrane permeability transition pore in a ...
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Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease
... To complement these results, we tested if the blocking of mPTP by CsA could have an effect on cell viability in striatal cells exposed to calcium stress (Additional file 5: Figure S5). Striatal cells were treated with 1 ...
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Anoxia mediated calcium release through the mitochondrial permeability transition pore silences NMDA receptor currents in turtle neurons
... mitochondrial pore formation is intracellular/matrix pH, as isolated mitochondria exposed to solutions of pH ...mitochondrial permeability of those exposed to pH ...mitochondrial permeability (Hunter ...
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Protective effects of potassium transport in mitochondria from rat myometrium under activation of mitochondrial permeability transition pore
... Thus, MPTP induction under in hibited K + transport results in the increased matrix ROS generation rate, while activation of K + trans membrane transport may protect the mitochondri[r] ...
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<p>Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening</p>
... In the fi rst phase, 30 rats were divided into the following 5 groups with 6 rats per group: (i) ischemia-reperfusion group (IR): As described above; (ii) solvent group (Vehicle): The rat[r] ...
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The influence of ATP-dependent K(+)-channel diazoxide opener on the opening of mitochondrial permeability transition pore in rat liver mitochondria
... Возврат Са 2+ в матрикс после перевода поры в закрытое со- стояние с помощью циклоспорина А также по- казывает, что при открывании поры происхо- дит активация циклического транспорта С[r] ...
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Effect of Fish and Flaxseed Oil Supplementation on Isoprenaline-Induced Myocardial Infarction in Rats: Inhibition of Mitochondrial Permeability Transition Pore Opening
... The findings of the present study in experimental group 1 treated with isoproterenol demonstrated severe myocardial injury and elevated serum CKMB level.. There are many proposed mec[r] ...
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Mitochondria in energy limited states: mechanisms that blunt the signaling of cell death
... the permeability transition pore, to assemble additional protein release channels, and to release pro-apoptotic ...mitochondrial permeability transition pore and release of ...
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Effect of Methanol Leaf Extract of Blighia Sapida on Mitochondrial Membrane Permeability Transition Pore Opening and Blood Glucose Levels in Normal and Streptozotocin-Induced Diabetic Rats
... mitochondrial permeability transition pore (MPT) opening which are related to the onset, progression and pathological consequences of diabetes ...MPT pore plays an important role in modulation ...
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Influence of Tl(+) on the Ca(2+) and Na(+) movement across rat neonatal cardiomyocytes and rat heart mitochondria membranes
... permeability in experiments with RLM, injected into 400 mOsm medium containing 0–75 mM TlNO 3 and 125 mM NaNO 3 [29]. The swelling of nonener gized RHM increased steadily when the TlNO 3 concentration was ...
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