Peroxiredoxin 1
Peroxiredoxin 1 induces inflammatory cytokine response and predicts outcome of cardiogenic shock patients necessitating extracorporeal membrane oxygenation: an observational cohort study and translational approach
... Cardiogenic shock, irrespective of the etiology, is a state of systemic hypoperfusion and global tissue ischemia [3]. Although ECMO restores oxygenated blood to the ischemic tissue, reperfusion paradoxically worsens the ...
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Role of Peroxiredoxin 1 and Peroxiredoxin 4 in Protection of Respiratory Syncytial Virus-Induced Cysteinyl Oxidation of Nuclear Cytoskeletal Proteins
... for peroxiredoxin 1 (Prdx-1), Prdx-3, and Prdx-4 isoforms without changes in their total abundance, indicating that Prdxs were being oxidized in response to ...
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LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus
... PRDX1: Peroxiredoxin-1; qRT- PCR: Quantitative real-time polymerase chain reaction; RBP: RNA-binding protein; RIP: RNA immunoprecipitation; siRNA: Small interfering RNA; TCGA: The Cancer Genome Atlas ; TF: ...
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Peroxiredoxin 1 promotes invasion and migration by regulating epithelial-to-mesenchymal transition during oral carcinogenesis
... Tobacco smoking is the major risk factor for oral squamous cell carcinoma (OSCC). Previously, we found that nicotine up-regulates peroxiredoxin 1 (Prx1), an important antioxidant enzyme, and nuclear factor ...
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<p>Nicotine promotes cervical metastasis of oral cancer by regulating peroxiredoxin 1 and epithelial–mesenchymal transition in mice</p>
... Materials and methods: To analyze the mechanisms of nicotine-induced cervical metastasis, we investigated whether nicotine induced invasion, migration, and epithelial–mesenchymal transition (EMT) via regulating ...
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Original Article Peroxiredoxin-1 attenuates hepatic fibrosis by inhibiting TGF-β1/Smad3 and ROS signal pathways
... Abstract: By activation of the hepatic stellate cells (HSC), transforming growth factor β1 (TGF-β1) makes a major contribution to the development of hepatic fibrosis in response to increases in intracellular reactive ...
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<p>Silencing of Peroxiredoxin 1 Inhibits the Proliferation of Esophageal Cancer Cells and Promotes Apoptosis by Inhibiting the Activity of the PI3K/AKT Pathway</p>
... of peroxiredoxin 1 (PRDX1) on esophageal squamous carci- noma cells and determine whether it plays a role in regulating the PI3K/AKT signaling ...of peroxiredoxin 1 (PRDX1) and the activity of ...
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Peroxiredoxin 1 protects estrogen receptor α from oxidative stress induced suppression and is a protein biomarker of favorable prognosis in breast cancer
... Additional file 6: Figure S4. Viability and apoptosis assays. PRDX1 knockdown does not alter cell growth or viability in ZR-75-1 and T47D breast cancer cell lines. ZR-75-1 (A) and T47D (B) cells were grown ...
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Peroxiredoxin 1 silencing inhibited the growth and promoted apoptosis of pancreatic cancer cells via targeting <em>FOXO3</em> gene
... Material and methods: Human pancreatic normal cells HPDE6-C7 and pancreatic cancer cells PANC-1 were randomly divided into control group, Prx1-silencing (si-Prx1) group, Prx1/ FOXO3 dual-silencing (si-Prx1/FOXO3) ...
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Peroxiredoxin 1 Is Required for Efficient Transcription and Replication of Measles Virus
... In this study, Prdx1 was identified as a host factor that bound to MeV-N TAIL (Fig. 1). MeV infection did not induce intra- cellular peroxide in HEK293-SLAM cells at 24 hpi when the N protein was expressed largely ...
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Proteomic analysis of retinal pigment epithelium cells after exposure to UVA radiation
... including peroxiredoxin-1 (PRDX1), heat-shock protein 27 (Hsp27), protein disulfide-isomerase (PDI), calreticulin (CALR), 78 kDa glucose-regulated protein (GRP78), alpha crystalline B chain, cell division ...
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The protective effect of peroxiredoxin II on oxidative stress induced apoptosis in pancreatic β-cells
... Detection of PRDX2, both at transcript and protein levels in the mouse pancreas, isolated mouse islets and the clonal MIN6 cells is consistent with previous find- ings that demonstrated the presence of PRDX2 in the ...
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Current Advances in Understanding of Peroxiredoxin 6 as a Bifunctional Antioxidative Catalytic Protein
... Nrf2 regulates Prdx6 gene expression, the effect of siRNA detected against Nrf2 and its cytoplasmic repressor, Kelch like ECH-associated protein (Keap 1), on Prdx6 promoter-mediated expression were analyzed. A ...
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Expression of a Mitochondrial Peroxiredoxin Prevents Programmed Cell Death in Leishmania donovani
... immunofluorescence analysis also corroborated that this pro- tein localizes to the single mitochondrion of the parasite. The anti-LdmPrx antibody staining perfectly colocalized with the MitoTracker dye, a marker for ...
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Toxoplasma gondii peroxiredoxin promotes altered macrophage function, caspase-1-dependent IL-1β secretion enhances parasite replication
... T. gondii Prx coding sequence, accession number 305718, as described elsewhere [15] was used to prepare recombinant protein [16]. In brief, the coding sequence was cloned, in frame, into an expression vector and tagged ...
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UV crosslinked mRNA-binding proteins captured from leaf mesophyll protoplasts
... “response to light stimuli” and “defense response to bacterium” while another 83 candidate RBPs were also involved in other processes, such as “response to heat”, “transmembrane transport” and “nucleosome assembly” ...
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Phosphoproteins regulated by heat stress in rice leaves
... two-dimensional electrophoresis (2-DE). Protein con- centrations were measured according to Bradford [39]. Focusing of the first dimension took place on a Pro- tean IEF Cell (Bio-Rad, USA). After isoelectric focus- ing, ...
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Comparative Expression Analysis of Rice and Arabidopsis Peroxiredoxin Genes Suggests Conserved or Diversified Roles Between the Two Species and Leads to the Identification of Tandemly Duplicated Rice Peroxiredoxin Genes Differentially Expressed in Seeds
... Functions were characterized for three genes in this network: LOC_Os07g28280, encoding a rice ubiquitin- related modifier 1 (RURM1) involved in mobilizing Active MITE mPing (Tsukiyama et al. 2013); ...
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Enhanced radiation response in radioresistant MCF-7 cells by targeting peroxiredoxin II
... target, peroxiredoxin II (PrxII), is overexpressed in radioresistant MCF+FIR3 breast-cancer cells and found that its expression and function is associated with breast-cancer radiation sensitivity or ...
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Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis
... The second leading cause of cancer death worldwide and the sixth most common cancer in the world is hepatocellular carcinoma (HCC). The age-standardized rate per 100,000 ranges from 13.4 (Guinea-Bissau) to 78.1 ...
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