Peroxisome proliferators
Peroxisome Proliferators Activated Receptor (PPAR) agonists activate hepatitis B virus replication in vivo
... Peroxisome Proliferators Activated Receptor (PPAR) agonists activate hepatitis B virus replication in vivo RESEARCH Open Access Peroxisome Proliferators Activated Receptor (PPAR) agonists activate hep[.] ...
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Independent Activation of Hepatitis B Virus Biosynthesis by Retinoids, Peroxisome Proliferators, and Bile Acids
... Independent activation of HBV biosynthesis by retinoids, peroxisome proliferators, and bile acids in human embryonic kidney 293T cells. Previously, it has been shown that, when both nuclear receptor ...
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Role of nuclear receptor-independent pathways in the mechanism of action of peroxisome proliferators
... can play a role in signaling and activation of downstream mediators of cell proliferation. Activation of NADPH oxidase and production of superoxide occurs as a result of Kupffer cell activation [69]. As a result, ...
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In Vivo Regulation of Hepatitis B Virus Replication by Peroxisome Proliferators
... with peroxisome prolif- erators, the level of pregenomic RNA in both male and female mice is proposed to be increased to a limited degree but suf- ficiently to permit the efficient conversion of core polypeptide ...
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Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study
... pharmacologic exposure of patients to the hypolipidemic drugs gemfibrosil, and clofibrate, which are potent rodent peroxisome proliferators, has not revealed any increased risk of hepatocellular cancer or ...
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Pioglitazone modulates the proliferation and apoptosis of vascular smooth muscle cells via peroxisome proliferators-activated receptor-gamma
... TZDs: Thiazolidinediones; PPAR γ : Peroxisome proliferators-activated receptor gamma; VSMCs: Vascular smooth muscle cells; PCI: Percutaneous coronary intervention; CAD: Coronary artery d[r] ...
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Targeting 3-phosphoinositide-dependent protein kinase 1 by N-acetyl-cysteine through activation of peroxisome proliferators activated receptor alpha in human lung cancer cells, the role of p53 and p65
... Our results showed that NAC increased protein expression of PPAR α and the synergism of NAC and PPAR α ligands on cell growth inhibition demonstrated an important role of this nuclear tr[r] ...
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Modulation Peroxisome Proliferators Activated Receptor alpha (PPAR α) and Acyl Coenzyme A: Cholesterol Acyltransferase1 (ACAT1) Gene expression by Fatty Acids in Foam cell
... Between factors in the atherosclerosis, macrophages have the most important role. These cells uptake modified low density lipoproteins (m-LDL) particles such as oxidized LDL (ox-LDL) by scavenger receptors, that leads ...
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Reversal of High dietary fructose-induced PPARα suppression by oral administration of lipoxygenase/cyclooxygenase inhibitors
... We initiated studies to test the effects of lipoxygenase/ cyclooxygenase inhibitors on the metabolic and hepatic status of HFF rats. We examined two structurally different LOX/COX inhibitors because NDGA, which has ...
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Deficiency of iNOS-derived NO accelerates lipid accumulation-independent liver fibrosis in non-alcoholic steatohepatitis mouse model
... : Peroxisome proliferators-activated receptor alpha; NAFLD: Non-alcoholic fatty liver disease; IR: Insulin resistance; NAFL: Non-alcoholic fatty liver; VLDL: Very low-density lipoprotein; MTP: Microsomal ...
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The Protective Effect of Sodium Hyaluronate on the Cartilage of Rabbit Osteoarthritis by Inhibiting Peroxisome Proliferator Activated Receptor Gamma Messenger RNA Expression
... Purpose: The purpose of this study was to study the protective effect and influence of sodium hyaluronate (Na- HA) on mRNA expression of peroxisome proliferators-activated receptor gamma (PPAR- γ ) in ...
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The life of the peroxisome: from birth to death
... of peroxisome formation in ...for peroxisome biogenesis from the ER ...containing peroxisome markers [18] leading the authors to speculate that CNV may manipulate peroxisome biogenesis to ...
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Peroxisome protein import: a complex journey.
... mutant could not import into peroxisomes in vivo. Using SPR, two binding events of wild-type PCS60 to PEX5 with different affinities could be detected. The high affinity binding event required the PTS1 sequence but the ...
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Functional Characterization of Peroxisomes and Peroxisome Proliferator Activated Receptor-Gamma in the Chicken Respiratory System
... term peroxisome proliferator activated receptor was coined when activation of peroxisome proliferator activated receptor alpha (PPAR α) resulted in proliferation of peroxisomes by changing expression of ...
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Selective peroxisome proliferator-activated receptorα modulators (SPPARMα): The next generation of peroxisome proliferator-activated receptor α-agonists
... Dyslipidemia is a major risk factor for cardiovascular (CV) disease – the primary cause of death, worldwide. Although reducing levels of low-density lipoprotein-cholesterol can significantly reduce CV risk, a high level ...
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An efficient positive selection procedure for the isolation of peroxisomal import and peroxisome assembly mutants of Saccharomyces cerevisiae.
... Expression, import and activity of the bleomycin- luciferase protein: For the isolation of peroxisomal import and peroxisome assembly mutants, a plasmid was constructed, [r] ...
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TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria
... The peroxisome proliferator perfluorodecanoic acid inhibits the peripheral-type benzodiazepine receptor (PBR) expression and hormone-stimulated mitochondrial cholesterol [r] ...
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Original Article The association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene with the metabolic characteristics in Chinese women with polycystic ovary syndrome
... the peroxisome Proliferator-activated receptor-gamma2 PPARγ2) gene that account for metabolic dysfunction in women with polycystic ovary syndrome (PCOS) remain ...
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<em>PPARgamma-2</em> and <em>ADRB3 </em>polymorphisms in connective tissue diseases and lipid disorders
... Background: The aim of the research genetic study was to investigate the association between variants (C1431T and Pro12Ala) of the peroxisome proliferator-activated receptor ( PPARgamm[r] ...
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Impaired degradation of leukotrienes in patients with peroxisome deficiency disorders
... The degradation of leukotrienes by beta-oxidation from the omega-end proceeds in peroxisomes (Jedlitschky et al. J. Biol. Chem. 1991. 266:24763-24772). Peroxisomal degradation of leukotrienes was studied in humans by ...
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