personalized and precision medicine
An integrative approach for building personalized gene regulatory networks for precision medicine
... An integral component for disease treatment based on a personalized GRN is to have a patient’s genotype infor- mation available. Genotyping patients may allow doctors to select effective drugs while preventing ...
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Precision medicine and personalized breast cancer: combination pertuzumab therapy
... In the current era of targeted and personalized therapeu- tics in cancer, the classic approach of “one size fits all” cancer therapy is increasingly becoming obsolete. Since the remarkable successes of trastuzumab ...
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Personalized comprehensive molecular profiling of high risk osteosarcoma: Implications and limitations for precision medicine
... in personalized medicine, these cases highlight the need for alternative, more effective approaches to guiding treatment decisions in this disease given the large volume of data generated by molecular ...
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Viscoelasticity as a measurement of clot structure in poorly controlled type 2 diabetes patients: towards a precision and personalized medicine approach
... clinical medicine should focus on precision medicine, and the current broad understanding is that precision medicine may in future, provide personalized targets for preventative ...
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The significance of microbiome in personalized medicine
... called personalized medicine, have opened a new window in medical science, and the association between microbiome and personalized medicine seems to be one of the most interesting aspects of ...
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Genomics in Personalized Medicine
... Another important example of genomic applications in precision medicine is seen in the treatment of melanoma, cancer of the skin. BRAF is the human gene that controls the synthesis of a protein called B- ...
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The forthcoming era of precision medicine
... of personalized medi- cine, in which individual data on genomics, proteomics and the environment are inte- grated and applied to personal health care: diagnosis, prevention and treatment ...(1). ...
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Precision medicine as a promising tool to empower research in healthcare industry
... industry, precision or personalized medicines ensures targeted drug discovery and development processes employing artificial intelligence and existing datasets to perform better ”in silico”’ target ...
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From genomic medicine to precision medicine: highlights of 2015
... In relation to the first issue, Siwo et al. highlighted [31] how cloud-computing and genetic testing are being combined in structured education programs to leverage the large genetic variation existing in Africa, thus ...
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Coordinating an Oncology Precision Medicine Clinic Within an Integrated Health System: Lessons Learned in Year One
... Precision medicine is a buzzword in contemporary health ...If precision medicine is defined broadly enough, it could be equated with medicine in general and loses any real ...
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<p>The surgical perspective in precision treatment of diffuse gliomas</p>
... Abstract: Over the last decade, advances in molecular and imaging-based biomarkers have induced a more versatile diagnostic classification and prognostic evaluation of glioma patients. This, in combination with a growing ...
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Precision medicine in pediatric oncology
... adult medicine, many current molecular profiling programs for patients with relapsed or refractory tumors aim to sequence tumor ge- nomes, in order to identify genetic alterations and switch off related genes with ...
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Physiology and technology for the ICU in vivo
... Personalized medicine for critically ill patients has gained much interest in recent years, mainly as a re- sponse to the lack of efficacy of randomized controlled trials as a vehicle for improving the ...
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Big data hurdles in precision medicine and precision public health
... that precision medicine will provide tailored health care to patients and will yield lower rates of associated adverse ...Although precision medicine aims at preven- tion, diagnosis and ...
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Genetics of scleroderma: implications for personalized medicine?
... HGF was not a susceptibility locus for SSc but was asso- ciated with end-stage lung disease among Japanese SSc patients [28]. A careful phenotypic characterization of patients examined i[r] ...
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Toward precision medicine of breast cancer
... In an in silico evaluation, [134] classified drugs involved in cancer therapy [175] could be separated into two general classes, i.e., (i) agents that target specific receptors such as t[r] ...
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Personalized medicine in psychiatry: problems and promises
... A rapidly advancing area likely to have a major influence on personalized medicine in psychiatry is neuroimaging, and more specifically, neuroimaging genomics. Briefly, imaging genetics uses imaging ...
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Stroke genetics: prospects for personalized medicine
... Epidemiologic evidence supports genetic factors being important in stroke risk. Recent advances, primarily GWAS, are transforming what we know about the genet- ics of multifactorial stroke, and are identifying novel ...
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A Parallel Software Pipeline for Personalized Medicine
... Abstract: Personalized medicine is an aspect of the P4 medicine (predictive, preventive, personalized and participatory) based precisely on the customization of all medical characters of each ...
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Genetic basis for personalized medicine in asthma
... towards personalized medicine in asthma, with associated benefits including avoidance of adverse side effects and the adequate control of the patients’ asthma, avoiding exacerbation and hospitalization due ...
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