pH sensitive delivery system
Preparation and characterization of gelatin-poly(methacrylic acid) interpenetrating polymeric network hydrogels as a ph-sensitive delivery system for glipizide
... polymerization process using potassium per sulfate, as sample of IPN hydrogels equivalent to 20 mg of glipizide free radical polymerization initiator. Free radical was used in each test. Drug release from the IPN ...
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A pH-sensitive Delivery System for the Prevention of Dental Caries Using Salivary Proteins
... the delivery system at all ratios, which is beneficial, as the loading can therefore be ...different pH values including 3, 4, 5, and ...at pH 5 and dental erosion occurs at pH ...the ...
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pH-Sensitive carboxymethyl chitosan-modified cationic liposomes for sorafenib and siRNA co-delivery
... To characterize the accumulation of CMCS-SiSf-CL in tumor tissue, CMCS-SiSf-CL (CMCS/siRNA = 3.8:1, weight ratio) was administered to Kunming mice bearing H22 cells via the tail vein and the fuorescence signal was ...
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PH SENSITIVE HYDROGELS OF LEVOFLOXACIN HEMIHYDRATE FOR OPHTHALMIC DRUG DELIVERY
... Stimuli sensitive hydrogels are of very importance in this regard, they undergo reversible volume and/or sol-gel phase transitions in response to physiological (temperature, pH and presence of ions in ...
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A pH-sensitive multifunctional gene carrier assembled via layer-by-layer technique for efficient gene delivery
... 2 mL of complete RPMI 1640 culture medium. At a conflu- ence level of 70%–80%, the growth medium was removed and the cells were washed twice with PBS buffer. The medium was replaced with serum free medium (pH ...
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Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells
... a pH-responsive PEG layer that detached prior to cell ...the pH-responsive block co-polymer polyethylene glycol-b-polyaspartic acid (PEG-b-PAsp) using a modified emulsion ...was pH-sensitive, ...
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EpCAM aptamer-functionalized polydopamine-coated mesoporous silica nanoparticles loaded with DM1 for targeted therapy in colorectal cancer
... and pH-sensitive drug delivery system based on EpCAM APt-functionalized MSNs, which can effectively deliver the anticancer drug DM1 to human colorectal adenocarcinoma cells and enhance ...
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Dual-pH Sensitive Charge-reversal Nanocomplex for Tumor-targeted Drug Delivery with Enhanced Anticancer Activity
... dual-pH sensitive and charge-reversal PMLA-based nanocomplex was prepared for effective drug delivery, enhanced cellular uptake, and intracellular drug release ...of pH-sensitive ...
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Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems
... drug delivery system for the targeted, pH-sensitive delivery of a chemotherapeutic drug into cancer ...whole system has the capacity for simultaneous tracking of the carrier and ...
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Design and evaluation of ph sensitive minitablets for chronotherapeutic delivery of theophylline
... A pH-sensitive tablet in capsule system intended to approximate the chronobiology of nocturnal asthma is proposed for site specific release to the ...The system comprising of Eudragit S-100 ...
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pH-sensitive degradable nanoparticles for highly efficient intracellular delivery of exogenous protein
... this system to encapsulate a functional protein (apoptin) resulting in regression of tumor cells and induction of ...intracellular delivery of protein and peptide drugs and may become a powerful tool for ...
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Theranostic pH-sensitive nanoparticles for highly efficient targeted delivery of doxorubicin for breast tumor treatment
... concentration was measured by using the BCA Protein Assay Reagent Kit (Beyotime Institute of Biotechnology). The protein samples (50 mg) were electrophoresed on a 10% sodium dodecyl sulfate polyacrylamide gel ...
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Anti-EphA10 antibody-conjugated pH-sensitive liposomes for specific intracellular delivery of siRNA
... EPSLR delivery siRNA into MCF-7/ADR cells, the cells were treated with different formulations for 4 hours and MDR1 expression was analyzed using the Western blot assay after 72 ...the delivery of MDR1-siRNA ...
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pH-sensitive poly(lactide-co-glycolide) nanoparticle composite microcapsules for oral delivery of insulin
... 510 System (Carl Zeiss Meditec AG, Jena, Germany) equipped with a laser operating at 488 nm for fluorescence excitation to observe the composite microcapsules’ fate in the GI ...
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Synthesis & design of chitosan derivative pH stimuli sensitive microparticles for colon targeted metronidazol delivery
... Drug delivery systems that can precisely control the release rate of target drug to a specific body site have been gained lots of ...targeted delivery of bioactive molecules to specific sites of the ...
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Transferrin receptor-targeted pH-sensitive micellar system for diminution of drug resistance and targetable delivery in multidrug-resistant breast cancer
... micelles (DSPE-PEG 2000 :PHIS-PEG 2000 = 35:65, w/w) were chosen for good size distributions and proper pH sensitivity. As shown in Table 1 and Figure 2A, the average hydrody- namic diameter of the HD micelles was ...
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Efficient Cooperative Control System for pH Sensitive Nanorobots in Drug Delivery
... for pH sensitive nanorobots to trace the measured pH values, and reach the tumor cells with the lowest pH ...drug delivery by a swarm of ...drug delivery system in 3D ...
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pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system
... a pH and temperature dual-sensitive mucoadhesive vaginal gel formulation was developed for gynecological ...The pH-sensitive cleavable mPEG-Hz- CHEMS was designed as a modified ...
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A novel application of maleimide for advanced drug delivery: in vitro and in vivo evaluation of maleimide-modified pH-sensitive liposomes
... By contrast to iv injection (Supplementary Picture S1), sc injection can prevent the liposomes with a mean diam- eter of above 100 nm from entering the blood circulation directly (Figure 5A) and thereby reduce the side ...
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pH-sensitive mebeverine microspheres for colon delivery
... Mebeverine hydrochloride (MBH) is having poor oral bioavailability and has some adverse effects, even though it shows direct action on the smooth muscle of the GIT (especially colon), because of this reason the ...
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