pharmacodynamic modeling
Pharmacodynamic modeling of bacillary elimination rates and detection of bacterial lipid bodies in sputum to predict and understand outcomes in treatment of pulmonary tuberculosis
... One promising technique is serial sputum colony counting (SSCC). Colony-forming units (CFUs) of Mycobacterium tuber- culosis are counted after incubation on selective agar and bacil- lary clearance is measured. Response ...
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Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers
... The characters of PK behaviors and its influences to the values of plasma glucose levels have been studied in several hypoglycemic drugs [23, 24]. Toshiyuki Takanohashi et al. reported the pk-pd. modeling ...
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Pharmacodynamic Modeling of Bacillary Elimination Rates and Detection of Bacterial Lipid Bodies in Sputum to Predict and Understand Outcomes in Treatment of Pulmonary Tuberculosis
... One promising technique is serial sputum colony counting (SSCC). Colony-forming units (CFUs) of Mycobacterium tuber- culosis are counted after incubation on selective agar and bacil- lary clearance is measured. Response ...
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Improving pharmacokinetic-pharmacodynamic modeling to investigate anti-infective chemotherapy with application to the current generation of antimalarial drugs.
... Mechanism-based pharmacokinetic-pharmacodynamic (PK/PD) modelling is the standard computational technique for simulating drug treatment of infectious diseases with the potential to enhance our understanding of ...
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Glibenclamide population pharmacokinetic/pharmacodynamic modeling in South African type 2 diabetic subjects
... Patients and methods: A total of 24 type 2 diabetic patients participated in a glibenclamide dose-escalation study during which glibenclamide, glucose, and insulin concentrations were quantified, while the dose of ...
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Integrated pharmacokinetic–pharmacodynamic modeling to evaluate empiric carbapenem therapy in bloodstream infections
... Methods: Carbapenem minimum inhibitory concentrations (MICs) were generated for non- repeat GNB-BSI obtained in 2013–2014 from two hospitals. Monte Carlo simulations were used to assess the cumulative fraction of ...
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Explaining the Poor Bacteriologic Eradication Rate of Single-Dose Ceftriaxone in Group A Streptococcal Tonsillopharyngitis: A Reverse Engineering Solution Using Pharmacodynamic Modeling
... Population modeling techniques were ap- plied to pharmacokinetic data derived from paired plasma and tonsil samples from 153 children to assess the contribution of pharmacokinetic variability to patients’ ...
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Population Pharmacokinetic Pharmacodynamic Modeling of Caffeine Using Visual Analogue Scales
... Simultaneous fit of PK and PD was not successful which could be due to high variability in PD. Therefore, a sequential fit was the most appropriate modeling scheme. While there are multiple methods to implement a ...
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Pharmacokinetic Pharmacodynamic modeling of the analgesic effect of bupredermTM, in mice
... PK-PD modeling is of par- ticular importance to optimize drug use by designing rational dosage forms and dosage regimes in clinical pharmacology and pharmaceutical ...PK-PD modeling to characterize the ...
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Ribozyme Pharmacokinetic Screening For Predicting Pharmacodynamic Dosing Regimens
... for pharmacodynamic studies was selected based on plasma concentration data since it could not be determined whether bolus or continuous intravenous administration resulted in higher tumor ...follow-on ...
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Atomoxetine for the treatment of attention-deficit/hyperactivity disorder in children and adolescents: a review
... Objective: This review examines and summarizes the pharmacodynamic and pharmacokinetic properties, short- and longer-term effi cacy, the moderating effect of comorbid disorders, as well[r] ...
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Are In Vitro Susceptibilities to Azole Antifungals Predictive of Clinical Outcome in the Treatment of Candidemia?
... Relative to fluconazole, a paucity of data exists exploring the relationship between voriconazole susceptibility or pharmacodynamic parameters and clinical outcomes. Pfaller and colleagues published phase III ...
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A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects
... Subjects and methods: Thirty healthy male Korean subjects were administered with rosu- vastatin (20 mg/day), valsartan (160 mg/day), and both drugs concomitantly for 4 days in a randomized, open-label, multiple-dose, ...
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Common use of dietary supplements for bipolar disorder: a naturalistic, self-reported study
... may reduce effectiveness of benzodiazepines and metha- done due to induction of cytochrome P450 3A4 enzyme (Izzo and Ernst 2009). Pharmacodynamic interactions occur when drugs act upon the same or related ...
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Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG®) in patients with mycosis fungoides: an open-label trial
... The pharmacodynamic variables measured in this trial to characterize HeberPAG W formulation are well-known IFN- induced genes, classical surrogate markers of IFN bio- logical ...
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Statins significantly reduce mortality in patients receiving clopidogrel without affecting platelet activation and aggregation: a systematic review and meta-analysis
... The effect of combination of statin plus clopidogrel on platelet activity have aroused people’s concern. Lau et al. first reported the negative interference of atorvastatin with the antiplatelet effect of clopidogrel ...
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Time-kill assay and post-antibiotic effect of acetone extract of canarium odontophylum leaves against methicillin-resistant staphylococcus aureus (mrsa)
... Leaf in Combination with Oxacillin against Methicillin- Resistant Staphylococcus aureus (MRSA) ATCC 33591. Pharmacodynamic interaction of Quercus infectoria galls extract in [r] ...
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Insect tolerance to a neurotoxic polypeptide: pharmacokinetic and pharmacodynamic aspects
... On the basis both of the present and previous data (Herrmann et al. 1990), there is no doubt that tolerance in an insect to a neurotoxic polypeptide includes factors working at the pharmacokinetic level which are similar ...
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The Impact of Anesthetics Drugs on Memory and Memory Modulation under General
... A significant endpoint of general anesthesia is the loss of memory, indeed a terrible complication of narcosis is the anesthesia awareness (AA), a rare condition that occurs when surgical patients can recall their ...
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Pharmacokinetic-Pharmacodynamic Model for the Effect of l-Arginine on Endothelial Function in Patients with Moderately Severe Falciparum Malaria.
... Data. Patient data were available from two previous studies and are de- scribed elsewhere (11, 16, 17). Briefly, these studies included an observa- tional study that addressed the natural history of arginine recovery ...
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