Pharmacokinetic profiles
A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles
... Methods: An open-label, two-treatment, two-period, two-sequence crossover study was con- ducted in 52 healthy male volunteers, who randomly received a single intravenous infusion of either of the two voriconazole ...
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Pharmacokinetic profiles of marbofloxacin following single and repeated oral administration in broiler chickens
... provides pharmacokinetic advantage such as long elimination half-life (Fitton, ...Important pharmacokinetic parameters of marbofloxacin like larger volume of distribution, optimum AUC and C max make it a ...
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In vitro antiplasmodial activity, pharmacokinetic profiles and interference in isoprenoid pathway of 2 aniline 3 hydroxy 1 4 naphthoquinone derivatives
... To further estimate the druggability of these naphtho- quinones derivatives were report their ADME descriptors and profiles and potential biological activities using an in silico approach are depicted in Table 1. ...
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Differential effects of hydrocortisone, prednisone, and dexamethasone on hormonal and pharmacokinetic profiles: a pilot study in children with congenital adrenal hyperplasia
... Mean ACTH, androstenedione, and 17-OHP values were all significantly lower following treatment with DEX when compared to HC (p = 0.016, p = 0.016, p < 0.001) and PDN (p < 0.001, p = 0.002, p < 0.001). ...
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Pharmacokinetic profiles of artesunate following multiple intravenous doses of 2, 4, and 8 mg/kg in healthy volunteers: Phase 1b study
... Table 2 Mean CV% PK parameters of dihydroartemisinin DHA, an active metabolite of artesunate AS, by noncompartment analysis NCA following multiple intravenous administrations of AS at do[r] ...
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Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles
... PK profiles of quetiapine; the GMR and 90% CI of food effect on T max , C max , AUC 0→36 , and AUC 0→∞ in this study fell outside both equivalence intervals, which may be due to limited sample size and ...
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Therapeutic efficacy, pharmacokinetic profiles, and toxicological activities of humanized antibody-drug conjugate Zt/g4-MMAE targeting RON receptor tyrosine kinase for cancer therapy
... The use of mouse and cynomolgus monkey models for the PK profiling provides insight into the dynamics of H-Zt/g4-MMAE in vivo. We showed that the PK profile of H-Zt/g4-MMAE fits into the two-compartment model with the t½ ...
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Random pharmacokinetic profiles of EC-MPS in children with autoimmune disease
... All variables under study were investigated for normality using the Kolmogorov Smirnov normality test and most variables were found to be not normally distributed. For consistency, all statistical measures of parameters ...
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Mimicking in vivo exposures to drug combinations in vitro : anti tuberculosis drugs in lung lesions and the hollow fiber model of infection
... In-vitro pharmacokinetic profiles for lung lesion homogenate generated in the hollow fiber system fell within the intervals predicted by the population pharmacokinetic models taking into account ...
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In vitro antimicrobial and α-glucosidase inhibitory potential of enantiopure cycloalkylglycine derivatives: Insights into their in silico pharmacokinetic, druglikeness, and medicinal chemistry properties
... and pharmacokinetic profiles, the compounds were subjected to in silico molecular property and absorption, distribution, metabolism, and excretion (ADME) predictions using Molinspiration and SwissADME ...
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Intranasal Delivery of Two Benzodiazepines, Midazolam and Diazepam, by a Microemulsion System
... Study 1 (Table 1) after IV administration was statisti- cally different compared with the average value obtained after IV administration to rabbits of study 2, i.e., 34.19 ± 5.88 min vs. 19.57 ± 7.24 min (t-test, p < ...
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PHARMACOKINETIC AND PHARMACODYNAMIC CHANGES IN ELDERLY PEOPLE
... affect pharmacokinetic (PK) and pharmacodynamic (PD) status of drugs in elderly people, leading to clinically relevant consequences with regard to safety and ...
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The Pharmacokinetic Interaction between Ivacaftor and Ritonavir
... the pharmacokinetic (PK) interaction between ivacaftor and ritonavir to explore the possibility of using ritonavir to boost plasma levels of ivacaftor in clinical ...PK profiles were analysed using ...
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Pharmacokinetic evaluation of intravenous artesunate in adults with uncomplicated falciparum malaria in Kenya: a phase II study
... the pharmacokinetic (PK) profile of IV AS in Kenyans in- fected with uncomplicated falciparum ...PK profiles observed in populations of healthy adults administered AS in another ...
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Measurement of pharmacokinetic parameters in histologically graded invasive breast tumours using dynamic contrast enhanced MRI
... Only a few studies have attempted to directly correlate DCE-MRI findings with prognostic factors such as tumour grade and nodal status in clinical studies of breast cancer [32-36]. None of these studies included ...
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Using Natural Language Processing to Extract Drug Drug Interaction Information from Package Inserts
... of pharmacokinetic studies that establish the absence of effect ...identify pharmacokinetic DDIs in drug package inserts and 2) classify pharmacokinetic DDI statements by their modality ...
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Synthesis and PAMPA Permeability Assay of New Sulfonyl Hydrazone Derivatives
... their pharmacokinetic prop- erties, as these properties are essential for the development of drug prototypes; the results obtained were motivating for the continuity of new ...
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An annotated corpus with nanomedicine and pharmacokinetic parameters
... In this work, we created and evaluated an annotated corpus with nanomedicine and pharmacokinetic parameters. FDA-approved nanomedicines were chosen due to the larger number of publications describing these ...
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A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects
... This study indicates that an FDC tablet of gemigliptin and metformin SR has comparable PD, PK, and tolerability profiles to separate tablets taken together in healthy males. The comparability between the FDC of ...
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In vivo pharmacokinetic studies of prodrugs of ibuprofen
... In vivo pharmacokinetic studies of N-Mannich base derivatives of ibuprofenamide as prodrugs were performed on rabbits. Ibuprofen and both the prodrugs (IBMB-M and IBMB-P) were administered orally and at different ...
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