phase cell cycle arrest
<p>DCZ0814 induces apoptosis and G0/G1 phase cell cycle arrest in myeloma by dual inhibition of mTORC1/2</p>
... cytometry using JC-1 dye. Only JC-1 green positive (lower right quadrant) cells were analyzed for the loss of MMP. (D) Columns represent the average percent of only JC-1 green positive cells from three independent ...
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Ethyl acetate fraction of garlic (Allium sativum) inhibits the viability of MCF7 and HepG2 through induction of apoptosis and G2/M phase cell cycle arrest
... In the present study, treatment by garlic fraction rich in LA and SAC induced apoptosis in MCF7 and HepG2 cancer cells as revealed by qPCR results which exhibited a significant upregulation in the apoptotic genes, Bax ...
9
Tissue specific G1 phase cell cycle arrest prior to terminal differentiation in Dictyostelium
... either arrest in G1 phase or they undergo a round of DNA synthesis and return to G2 ...and arrest in G1, a decrease in the cellular DNA content should be detectable between 12 and 18 hours of ...
12
Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo
... A549 cell model, CK AP/TPGS mixed micelles significantly inhibited cell growth, induced G0/G1 phase cell cycle arrest, induced cell apoptosis, and inhibited cell ...
10
Apoptosis and G<sub>2</sub>/M arrest induced by <em>Allium ursinum</em> (ramson) watery extract in an AGS gastric cancer cell line
... cancer cell growth in association with G 2 /M phase cell cycle arrest and/or induction of apoptosis mediated by organosulfur compounds, ie, diallyl disulfide and diallyl trisulfide, has ...
5
Suppression of STIM1 inhibits human glioblastoma cell proliferation and induces G0/G1 phase arrest
... growth arrest in human G401 rhabdoid tumor cells and human RD rhabdomyosarcoma cells ...on cell proliferation and cell cycle progression in U251 ...G1 phase progression through ...
9
The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells.
... At 32°C, these cells arrest in the G phase of the cell cycle, and the ability of the SV40 large T antigen to overcome this temperature-dependent block in cell division was examined.. The[r] ...
8
Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition
... Lycorine, a natural alkaloid extracted from Amarylli- daceae , has shown various pharmacological effects, such as anti-inflammatory activities, anti-malarial properties, emetic actions, anti-virus effects, and so on ...
6
<em>LEF1-AS1</em>, a long non-coding RNA, promotes malignancy in glioblastoma
... reduced cell proliferation, migration, and invasion, and induced cell- cycle G1 phase arrest and apoptosis in the U87 and U251 cell ...
10
Chloroformic fraction of Tanacetum vulgare L. induces cell cycle arrest and apoptosis in MCF7 cells
... leukemia cell line ...blocks cell cycle in G2/M phase in breast cancer cell line MDA-MB-468 as a result of CYP1 family enzyme metabolism but does not inhibit cell cycle of ...
5
Human Parvovirus B19 Nonstructural Protein (NS1) Induces Cell Cycle Arrest at G1 Phase
... (ataxia telangiectasia mutated) and ATR (ATM- and Rad3- related) members of the phosphoinositide kinase family (1). The activation of ATM and ATR induces activations of their downstream protein kinases, Chk1 and Chk2, ...
7
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction
... promoting cell cycle arrest, apoptosis, differentiation and senescence along with altered angiogenesis[30, ...31]. Cell senescence is recognized as senescent morphology as well as loss of ...
14
Original Article The antitumor effects and mechanisms of the novel compound Alocasia B against gastric cancer cells
... A cell line panel with 12 gastric cancer cells was screened to determine the cytotoxic properties of Alocasia B using an MTT ...the cell cycle and apoptosis by flow ...cancer cell lines ...
8
Influence of Carbon Monoxide on Growth and Apoptosis of Human Umbilical Artery Smooth Muscle Cells and Vein Endothelial Cells
... muscle cell (hUASMC) and human umbilical vein endothelial cell (HuVEC) and further evaluated the growth and apoptosis status of SMC and ...blocked cell cycle progress of SMC and HuVEC, more ...
16
Influenza A Virus Replication Induces Cell Cycle Arrest in G0/G1 Phase
... and cell cycle interac- tion, some positive-strand RNA viruses, namely, the coronavi- rus family, have been investigated ...many cell types (11, 22, 48). Some viral proteins and many cell ...
9
Biological Activity of N Hydroxyethyl 4 aza 2,3 didehydropodophyllotoxin Derivatives upon Colorectal Adenocarcinoma Cells
... autophagic cell death through a BCL-2 dependent ...and cell cycle arrest at S ...the cell death mechanism that is ...numerous cell substrates that can cause the characteristic ...
11
Effect of TLR2 on the proliferation of inflammation-related colorectal cancer and sporadic colorectal cancer
... mantle cell lymphoma, TLR2 promotes the proliferation of tumor cells, and it can also inhibit the cell cycle progression of mantle cell lymphoma, leading to G1 phase arrest ...
13
MERTK as a novel therapeutic target in head and neck cancer
... our cell lines UNC1062 treatment induced a cell cycle arrest in the G2 Phase due to unspecific off- target effects of this inhibitor since we observed this arrest independent of ...
17
Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin
... cancer cell lines. We found that CXCR4 silencing significantly inhibited cell growth, decreased colony formation, and enhanced cisplatin sensitivity while overexpression of CXCR4 rendered cells more ...
11
Praeruptorin A Inhibits Cervical Cancer HeLa Cell Growth and Invasion by Suppressing MMP-2 Expression and ERK1/2 Signaling
... PA induces cell cycle arrest at G0/G1 phase in human cervical cancer HeLa cells.. 107.[r] ...
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