phase I‐II study
A Phase I/II Study of the Protease Inhibitor Ritonavir in Children With Human Immunodeficiency Virus Infection
... a phase I/II study, are promising and have led to Food and Drug Admin- istration approval of ritonavir for pediatric use in children ...prompt study and the availability of appropriate ...
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Phase I/II Study of Gefitinib and Concomitant Preoperative Radiotherapy in Patients with Locally Advanced Rectal Cancer
... present study was to determine the RD of gefitinib, when combined concomitantly with hyper fractionated RT in a preoperative setting in rectal cancer ...the phase I part of the study it was ...
7
Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors
... CONTROL COHORT: ten dogs were treated just with conventional chemotherapy during the study and their characteristics and therapies are summarized in table 7. There were 3 mixed breed dogs and one each of the fol- ...
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Safety and hemostatic efficacy of fibrin pad in partial nephrectomy: Results of an open-label Phase I and a randomized, standard-of-care-controlled Phase I/II study
... thrombin on a VICRYL mesh backing, to seal the col- lecting system and control bleeding after partial neph- rectomy in growing pigs [8]. Compared to conventional management, the use of AFAB resulted in significantly less ...
8
Phase I results of a phase I/II study of weekly nab-paclitaxel in paediatric patients with recurrent/refractory solid tumours: A collaboration with innovative therapies for children with cancer.
... met study eligibility criteria, received ≥1 dose of nab-paclitaxel, and had a baseline efficacy assessment and either ≥1 postbaseline assessment or symptomatic ...receiving study therapy (confirmed ≥ 4 ...
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Epratuzumab (humanised anti CD22 antibody) in primary Sjögren's syndrome: an open label phase I/II study
... at study entry and at 6, 10, and 18 weeks (that is, 1 day, 4 weeks, and 12 weeks ...the study: ESR, C-reactive protein (CRP), complete blood count, renal and liver function tests, creatine phosphokinase, ...
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A Phase I/II Study of the Protease Inhibitor Indinavir in Children With HIV Infection
... In summary, although indinavir is a potent and generally well-tolerated antiretroviral agent (except for the relatively common occurrence of reversible hematuria and occasional nephrolithiasis at higher doses), the ...
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Promising investigational drug candidates in phase I and phase II clinical trials for mesothelioma
... two phase II studies in combination with nivolumab (NCT03048474 and ...three phase II studies. A phase II study of tremelimumab in patients with chemotherapy-resistant ...
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Targeted therapy in melanoma
... a phase I/II trial of 35 patients with progressive stage IV melanoma pretreated with no more than three previous chemotherapy ...placebo-controlled phase III trials investigating the addition ...
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Click here to download PDF version of the article !
... The study was conducted in two phases. In Phase I, an active and passive sampling of the ICU environment and the ventilators were conducted without the use of a ...ventilators). Phase ...
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The crystal structures of the low-temperature and high-pressure polymorphs of nitric acid
... current study, however, we have observed that this is not the case and instead a previously unobserved high-pressure phase, here termed phase-II, is found to be present under these ...
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A combined Phase I and II open-label study on the immunomodulatory effects of seaweed extract nutrient complex
... exploratory study conducted as an open- label dosing study, with two different doses randomized to participants, conducted in 2008 over 4 weeks (28 days) in Lismore, a regional city in northern New South ...
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An Initial Study on the Development of Gross Motor Primary School Pupils
... proposed study will be performed on primary school pupils in the ...this study will produce a result that showed that there was gross motor development impact during physical education ...activities. ...
5
An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects
... that phase I en- zymes were induced by SBR from baseline to week 4 providing evidence that the glucosinolate metabolites and other potential actives remained functional despite the manufacturing ...
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Safety, pharmacokinetics, and antitumor properties of anlotinib, an oral multi-target tyrosine kinase inhibitor, in patients with advanced refractory solid tumors
... in phase I study, a series of phase II clinical trials have been performed and initial efficacy has been observed in several types of solid tumor including colon adenocarcinoma, ...
9
A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis
... Safety was assessed by actively monitoring adverse events. Subjects were questioned weekly about adverse events which were then recorded. Participants attended three clinics during which weight, blood pressure, pulse ...
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In vitro effect of mitragynine on activity of drug metabolizing enzymes, n-demethylase and glutathione s-transferase in streptozotocin-induced diabetic rats
... no study available about the effect of mitragynine on drug metabolizing ...following study is designed to evaluate the possible effect of mitragynine on phase I and phase II drug ...
8
Emerging therapeutic potential of nanoparticles in pancreatic cancer: a systematic review of clinical trials
... nanoparticles, and not involving patients with pancreatic cancer. After appraising 53 full text articles, a further 50 were excluded because they were not clinical trials or involved the diagnosis or investigation of ...
20
Intradermal injection of a Tat Oyi based therapeutic HIV vaccine reduces of 1 5 log copies/mL the HIV RNA rebound median and no HIV DNA rebound following cART interruption in a phase I/II randomized controlled clinical trial
... M12). Tat Oyi is the first vaccine to demonstrate effi- cacy in the context of cART interruption, even though 21 other trials have tried and failed to show differences from the placebo group [31]. It is important to out- ...
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Lenvatinib and other tyrosine kinase inhibitors for the treatment of radioiodine refractory, advanced, and progressive thyroid cancer
... in Phase I studies, is 25 mg ...in Phase I study and confirmed in the subsequent Phase II and III studies, are hypertension, proteinuria, and gastrointestinal symptoms ...
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