Phe, phenylalanine
Diurnal variation of phenylalanine and tyrosine concentrations in adult patients with phenylketonuria: subcutaneous microdialysis is no adequate tool for the determination of amino acid concentrations
... of Phe and a relative deficiency in Tyr lead to neurological and cognitive impairment of variable degree ...a Phe-restrictive and Tyr-supplemented diet can prevent mental retardation and allows for normal ...
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Engineering Escherichia coli to overproduce aromatic amino acids and derived compounds
... the availability of substrates, over the growth and product formation rates. In one report, variations in oxygen supply (by changing aeration rates and impeller speeds) were tested over the L-PHE production ...
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Brain Phenylalanine Concentrations in Phenylketonuria: Research and Treatment of Adults
... Three adults with classical PKU, 1 man and 2 women, volun- teered for this study. Two of the subjects had never discontinued their medical product, and 1 had been off diet for ⬎20 years. All 3 subjects maintained blood ...
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Serum prolactin as a biomarker for the study of intracerebral dopamine effect in adult patients with phenylketonuria: a cross-sectional monocentric study
... High phenylalanine impairs intracerebral neuro- transmitter availability in multiple ways [2, ...hand, Phe can competitively inhibit rate-limiting enzymes in the synthesis of various transmitters ...hand, ...
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Human Neutrophil Heterogeneity Identified Using Flow Microfluorometry to Monitor Membrane Potential
... secretagogue phorbol myristate acetate (20 ng/ml) stimulated a uniform loss of fluorescence (apparent depolarization). The chemoattractant N-formyl-methionyl-leucyl-phenylalanine (f- Met-Leu-Phe) (0.1 µM) ...
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Adult cognitive outcomes in phenylketonuria: explaining causes of variability beyond average Phe levels
... acid phenylalanine (Phe; ...dopamine). Phe accumulation results in several and still incompletely known negative effects on the postnatal development of the brain as well as on the functioning of the ...
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Motility and Adhesiveness in Human Neutrophils: EFFECTS OF CHEMOTACTIC FACTORS
... Human peripheral blood neutrophils (PMN) obtained from healthy adults were examined in vitro with techniques adapted to assess the effects of chemotactic factors (CF) on cellular configuration and adhesiveness. The ...
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Phenylketonuria: Plasma Phenylalanine Responses to Different Distributions of the Daily Phenylalanine Allowance Over the Day
... Plasma (Phe) concentrations (in mi- cromoles per liter) in patients with PKU be- fore (time 0) and after breakfast (time 5 mm- utes) and lunch (time 185 minutes) that contained 25% and 3[r] ...
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Glycomacropeptide: long-term use and impact on blood phenylalanine, growth and nutritional status in children with PKU
... influencing phenylalanine (Phe) concen- trations and anabolism [1, ...low Phe glycomacropeptide (CGMP) containing a peptide component may be more efficacious ...
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Brain Imaging and Proton Magnetic Resonance Spectroscopy in Patients With Phenylketonuria
... blood phenylalanine (Phe) concentrations as well as to brain Phe concentrations measured by magnetic resonance ...brain Phe concentrations despite similar blood Phe ...barrier ...
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Early Screening for Tetrahydrobiopterin Responsiveness in Phenylketonuria
... of phenylalanine (Phe) metabolism due to more than 800 mutations in the gene encoding Phe-hydroxylase ...reduced Phe dietary tolerance, respectively. As Phe itself is a toxic substrate ...
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Dietary intervention in the management of phenylketonuria: current perspectives
... of phenylalanine (Phe) and if left untreated will lead to profound and irreversible intellectual disability in most ...a Phe-free protein substitute although newer treatment options mainly in ...
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Application of Magnetite Nanoparticles in Phenylalanine Removal from Water Samples
... stretching vibration of C=O in amino acid. Other peaks from 500-1600 are due to the bending vibrations of either C=C, C=O, C=C, and C=N bonds. In Fig. 2c, it can be clearly observed that there is an interaction between ...
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Identification of NCAM that interacts with the PHE CoV spike protein
... with PHE-CoV spike protein will facilitate the description of the binding domain of the spike protein, which will pre- sumably be the most effective target epitope for a spike protein-based subunit ...
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Consolidated production of coniferol and other high value aromatic alcohols directly from lignocellulosic biomass
... Consolidated biodegradation–biotransformation process In plants, 1 is rarely found in free form and occurs widely linked to various carbohydrates as glycosidic conjugate ester. 37 Thus we sought to develop a consolidated ...
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In silico identification of putative drug targets of chlamydia psittaci 6bc by subtractive genome approach
... Phenylalanine, tyrosine and tryptophan biosynthesis Metabolic pathways Biosynthesis of secondary metabolites Biosynthesis of antibiotics Biosynthesis of amino acids Phenylalanine, tyrosi[r] ...
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Efficacy, safety and population pharmacokinetics of sapropterin in PKU patients <4 years: results from the SPARK open-label, multicentre, randomized phase IIIb trial
... pre-study Phe toler- ance, lack of adherence to Phe-restricted diet over the past 3 months, lack of adherence to sapropterin, and a sapropterin-dose adjustment not conducted as per protocol were considered ...
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DISORDERS ASSOCIATED WITH THE METABOLISM OF PHENYLALANINE AND TYROSINE
... of L-phenylalanine did not cause phenyl- pyruvate or other abnormal products of phenlyalanine metabolism to appear in the urine. Larger doses of phenylalanine, 0.1 gm/kg, raised the conc[r] ...
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CHEMICAL AND CLINICAL OBSERVATIONS DURING TREATMENT OF CHILDREN WITH PHENYLKETONURIA
... After phenylalanine was restricted in the diet, the concentration of phenylalanine in the serum decreased to 10 mg/100 ml and phenylpyruvic acid could no longer be detected, even after c[r] ...
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PHENYLALANINE METABOLISM IN THE PHENYLPYRUVIC CONDITION II AN ATTEMPT TO CALCULATE THE DAILY INCORPORATION OF PHENYLALANINE INTO PROTEINS
... If a fraction of 90 per cent of the free pheRESULTS AND DISCUSSION nylalanine pool in one turnover time is incorpoDuring one turnover time of the phenylalanine rated into body proteins, [r] ...
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