Phosphatidic acid
Putting the pH into phosphatidic acid signaling
... PA is unique among phospholipids in that it contains a phosphomonoester headgroup rather than the phos pho- diesters in other phospholipids such as PS, in which the phosphate group is also linked to a serine (Figure 1). ...
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Phosphatidic acid: biosynthesis, pharmacokinetics, mechanisms of action and effect on strength and body composition in resistance-trained individuals
... glycerophospholipid phosphatidic acid (PA) appears to play an important role in mTORC1 activation by mechanical ...lysophosphatidic acid and subsequent binding to endothelial differentiation gene ...
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Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease
... Cyclic phosphatidic acid (cPA) is a natural phospholipid mediator with a unique cyclic phosphate ring structure at the sn -2 and sn- 3 positions of the glycerol ...
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Phospholipid Metabolism in Stimulated Human Platelets: CHANGES IN PHOSPHATIDYLINOSITOL, PHOSPHATIDIC ACID, AND LYSOPHOSPHOLIPIDS
... and phosphatidic acid (PA) as a consequence of thrombin or collagen ...Fatty acid and aldehyde analysis indicated phospholipase A 2 activity, with an apparent preference for diacyl ethanolamine ...
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New roles for Smad signaling and phosphatidic acid in the regulation of skeletal muscle mass
... Skeletal muscle is essential for normal bodily function and the loss of skeletal muscle (i.e. muscle atrophy/ wasting) can have a major impact on mobility, whole-body metabolism, disease resistance, and quality of life. ...
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The phosphatidic acid phosphatase lipin-1 facilitates inflammation-driven colon carcinogenesis
... During the last few years, our laboratory has been involved in delineating the role that a family of enzymes of the de novo lipid biosynthesis pathway, the lipins, has in proinflammatory responses (14–17). Lipins possess ...
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A Dual Role for Diacylglycerol Kinase Generated Phosphatidic Acid in Autoantibody-Induced Neutrophil Exocytosis
... binds to its antigen on the surface of primed cells, resulting in the activation of the heterotrimeric G protein Gi, thereby stimulating phosphatidylinositol 3-kinase (PI3K) type 1γ (PI3Kγ), which activates protein ...
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An efficient modified method for plant leaf lipid extraction results in improved recovery of phosphatidic acid
... by members of our laboratory [17]. After quenching the samples in hot isopropanol, a mixture of solvents, optimized for mass spectrometry with an electrospray ionization source, was added. The solvent mixture was chosen ...
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Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis
... caused phosphatidic acid accumulation and mammalian target of rapamycin complex 1 (mTORC1) activation, which were associated with enhanced protein levels of a key phospholipid biosynthetic enzyme ...
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Potassium and angiotensin II increase the concentrations of phosphatidic acid, phosphatidylinositol, and polyphosphoinositides in rat adrenal capsules in vitro
... We examined the effects of K+ and angiotensin II, the major regulators of aldosterone secretion, on phospholipid metabolism during incubation of glomerulosa-rich, adrenal capsules. Addition of increasing amounts of K+ ...
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Antifibrotic effects of 2 carba cyclic phosphatidic acid (2ccPA) in systemic sclerosis: contribution to the novel treatment
... Cyclic phosphatidic acid (cPA) is a naturally occurring lipid mediator that was first isolated from a slime mold [17]. cPA also exists in human sera. Similar to LPA, cPA is catalyzed by ATX; however, cPA ...
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The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid binding amphipathic helix
... Figure 5. CIDEA is a phosphatidic acid (PA)-binding protein. (A) Lipid strip assay showing the affinity of CIDEA-v5 for certain anionic phospholipids. (B) Interaction of CIDEA-v5 with PA beads. Binding was ...
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Purification, characterization, and bioinformatics studies of phosphatidic acid phosphohydrolase from Lagenaria siceraria
... of phosphatidic acid (PtdOH), which is formed by the action of two specific acyltransferases, namely, glyc- erol-3-phosphate acyltransferase (GPAT) and lysophos- phatidic acid acyltransferase ...
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Phospholipase D modified low density lipoprotein is taken up by macrophages at increased rate A possible role for phosphatidic acid
... Macrophage uptake of modified forms of LDL leads to cellular cholesterol accumulation. Upon incubation of LDL with phospholipase D (PLase D), a time- and enzyme dose- dependent production of phosphatidic ...
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A Phosphatidic Acid (PA) conveyor system of continuous intracellular transport from cell membrane to nucleus maintains EGF receptor homeostasis
... The intracellular concentration of the mitogen phosphatidic acid (PA) must be maintained at low levels until the need arises for cell proliferation. How temporal and spatial trafficking of PA affects its ...
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Measuring phosphatidic acid phosphohydrolase (EC 3 1 3 4) activity using two phosphomolybdate based colorimetric methods
... oyl-sn-glycero-3-phosphate, a commonly used represent- tative form of PtdOH. The level of activity as determined by these methods compare favorably with radioactive PAP activity assay methods [21,22]. Therefore, non-ra- ...
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Phosphatidylinositol-4,5-Bisphosphate and Phospholipase D-Generated Phosphatidic Acid Specify SNARE-Mediated Vesicle Fusion for Prospore Membrane Formation
... and phosphatidic acid (PA) induce neg- ative (concave) curvature while inverted cone shapes, such as lysophosphatidic acid (LPA), have the opposite effect (26, ...
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The effects of phosphatidic acid supplementation on strength, body composition, muscular endurance, power, agility, and vertical jump in resistance trained men
... 111). Phosphatidic acid purity and potency were analyzed by an ultra-performance liquid chromatograph with triple quadrupole mass spectrometry (LC/MS/MS) methods (Avanti Polar Lipids, ...
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Effects of oral phosphatidic acid feeding with or without whey protein on muscle protein synthesis and anabolic signaling in rodent skeletal muscle
... Phosphatidic acid (PA) is a diacyl-glycerophospholipid that is enriched in eukaryotic cell membranes and it can act as a signaling lipid ...lysophosphatidic acid (LPA) which ultimately results in ...
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Different species of phosphatidic acid are produced during neuronal growth and neurosecretion
... Among all the lipids, phosphatidic acid (PA) appears to have a particular function in these membrane-related phenomena’s. PA is the simplest glycerophospholipid and plays a key structural role as a ...
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