Phosphatidylinositol 4-phosphate
Hepatitis C Virus Stimulates the Phosphatidylinositol 4-Kinase III Alpha-Dependent Phosphatidylinositol 4-Phosphate Production That Is Essential for Its Replication
... Phosphatidylinositol 4-kinase III alpha (PI4KA) is an essential cofactor of hepatitis C virus (HCV) repli- ...in phosphatidylinositol 4-phosphate (PI4P) accumulation throughout the ...
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skittles, a Drosophila Phosphatidylinositol 4-Phosphate 5-Kinase, Is Required for Cell Viability, Germline Development and Bristle Morphology, But Not for Neurotransmitter Release
... The phosphatidylinositol pathway is implicated in the regulation of numerous cellular functions and responses to extracellular ...of phosphatidylinositol 4-phosphate by the ...
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Modulation of phosphatidylinositol 4-phosphate levels by CaBP7 controls cytokinesis in mammalian cells
... Figure S1 – Dot blot analysis of cellular PI4P levels in cells over-expressing CaBP7. Total cellular lipid was extracted from HeLa cells overexpressing mCh-CaBP7 or mCh- N1 control plasmid and spotted in the centre of a ...
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A Complex Comprising Phosphatidylinositol 4-Kinase IIIβ, ACBD3, and Aichi Virus Proteins Enhances Phosphatidylinositol 4-Phosphate Synthesis and Is Critical for Formation of the Viral Replication Complex
... Phosphatidylinositol 4-kinase III  (PI4KB) is a host factor required for the replication of certain picornavirus ...product phosphatidylinositol 4-phosphate (PI4P) colocalize to the ...
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Hepatitis C Virus NS5A Hijacks ARFGAP1 To Maintain a Phosphatidylinositol 4-Phosphate-Enriched Microenvironment
... Phosphatidylinositol 4-phosphate (PI4P) is well known to be upregulated during hepatitis C virus (HCV) replication. The role of PI4 kinases in HCV has been extensively investigated. Whether the PI4P ...
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Role of Phosphatidylinositol Phosphate Signaling in the Regulation of the Filamentous-Growth Mitogen-Activated Protein Kinase Pathway
... phospholipid phosphatidylinositol (PI) is a key event in the determination of organelle iden- tity and an underlying regulatory feature in many biological ...generate phosphatidylinositol ...
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Phosphatidylinositol 4-Kinase III Beta Is a Target of Enviroxime-Like Compounds for Antipoliovirus Activity
... and phosphatidylinositol 4-kinase III beta (PI4KB) have been identified as the targets of the replication inhibitors hippuristanol, brefeldin A, and PIK93, respectively (14, 30, 31, ...of ...
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Type II phosphatidylinositol 4 kinase regulates trafficking of secretory granule proteins in Drosophila
... II phosphatidylinositol 4-kinase (PI4KII) produces the lipid phosphatidylinositol 4-phosphate (PI4P), a key regulator of membrane ...
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Phosphatidylinositol-5-phosphate 4-kinase gamma accumulates at the spindle pole and prevents microtubule depolymerization
... [4]. Phosphatidylinositol 4,5-bisphosphate (PI4,5P2, hereafter referred to as PIP2) either binds to intracellular proteins and directly modulates their sub- cellular localization and activity or acts as a ...
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Enterovirus 3A Facilitates Viral Replication by Promoting Phosphatidylinositol 4-Kinase IIIβ–ACBD3 Interaction
... ABSTRACT Like other enteroviruses, enterovirus 71 (EV71) relies on phosphatidy- linositol 4-kinase III  (PI4KB) for genome RNA replication. However, how PI4KB is re- cruited to the genome replication sites of ...
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Role of phosphatidylinositol 3-kinase as an effector of Ras
... , 4 )P 2 and PtdIns( 3 , 4 , 5 )P 3 in dominant negative Ras-expressing cells is specific to this pathway and not a general phenomenon affecting other signalling pathways, a number o f other growth ...
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Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication
... and 4 siRNAs targeting 5,000 druggable genes (20,000 siRNAs) were tested for their ability to block replication of the Luc-1b HCV sub- genomic ...dylinositol 4-kinases PI4KA and PI4KB inhibited luciferase ...
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Acute regulation by insulin of phosphatidylinositol 3 kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle
... In conclusion, our work demonstrated an acute and coordi- nated regulation by insulin of the mRNA levels of key proteins involved in insulin action in the skeletal muscle of normal hu- mans. We have identified two ...
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A structural and functional analysis of the phosphatidylinositol 3-kinase
... stimulate phosphatidylinositol (PI) turnover and that PI turnover may be constitutively activated in oncogenically transformed cells suggests that these second messengers are involved in the regulation of cell ...
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The regulation and function of phosphatidylinositol 3-kinase
... complex protein interactions which may be involved in the function of PI 3-kinase seem to require the presence of both subunits. Indeed, expression studies in insect cells of the p i 10a subunit either alone or together ...
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Determinants of anti-vascular action by combretastatin A-4 phosphate: role of nitric oxide
... Further information is required regarding the mechanism of action of CA-4-P under in vivo conditions. The present study was designed to investigate the role of nitric oxide (NO) in determining the tumour vascular ...
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The PITP family of phosphatidylinositol transfer proteins
... Figure 4. Phospholipase C hydrolyses PI bis- phosphate (PIP 2 ) to generate the second messengers diacylglycerol and inositol ...PI phosphate 5-kinase, indicating that the synthesis of PIP 2 was ...
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COMPARATIVE PHYLOGENETIC ANALYSIS OF METHYLERYTHRITOL 4 PHOSPHATE (MEP) PATHWAY GENES IN ASTERAECAE FAMILY
... possesses distinctive organoleptic properties. Stevioside is reported to be 143 times sweeter than sucrose on a weight basis, but Rebaudioside-A is 242 times sweeter 3 . The aftertaste quality of Rebaudioside-A is better ...
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A Single Point Mutation in the Rhinovirus 2B Protein Reduces the Requirement for Phosphatidylinositol 4-Kinase Class III Beta in Viral Replication
... The formation of the replication membranes also critically depends on host factors such as phosphatidylinositol 4 (PI4)-kinase class 3b (PI4K3b) (21, 22, 27). In uninfected cells, PI4K3b is located at the ...
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KINETICS AND MECHANISM OF HYDROLYSIS OF TRI 4 CHLOROTHIOPHENYL PHOSPHATE ESTER VIA CONJUGATE ACID SPECIES
... Hydrolysis of Tri-4-chlorothiophenyl phosphate ester has been carried out in the region of 0.1-7.0 mol dm -3 HCl at 98 0 C. Acid log rate profile has a maximum at 4.0 mol dm -3 HCl and then decreases after ...
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