phospholipase A2 group IIA
Promoting effect of hepatitis B virus on the expressoin of phospholipase A2 group IIA
... In total, 308 patients clinically diagnosed with chronic HBV infection were recruited. According to the clinical, biochemical, serological, histopathological, abdominal ultrasound, computed tomography (CT) and magnetic ...
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An inhibitor of phospholipase A2 group IIA modulates adipocyte signaling and protects against diet-induced metabolic syndrome in rats
... The pharmacologic responses of a selective pla2g2a inhibitor 5-4-benzyloxyphenyl-4S-phenyl-heptanoylaminopentanoic acid [KH064] were not related to direct effects on adipocytes but rathe[r] ...
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Mobilization of potent plasma bactericidal activity during systemic bacterial challenge Role of group IIA phospholipase A2
... the circulation of baboons during a systemic inflammatory re- sponse results in the expression in plasma of potent bacteri- cidal activity toward S. aureus and other potentially invasive Gram-positive bacterial ...
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Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding
... IIA, 100 UI/ml of interferon-γ (IFNγ) at 37°C for 24 h, in the presence or absence of the indicated inhibitors. After 24 h, the phagocytic ability of the cells was mea- sured using FITC-dextran as a tracer [36]. ...
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<p>Overexpression of the phospholipase A2 group V gene in glioma tumors is associated with poor patient prognosis</p>
... phospholipases A2 (sPLA2s) are involved in various physiological processes, including defense mechanisms, bioactive lipid production, and cell ...the phospholipase A2 group III ...
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Antibacterial properties of chicken intestinal phospholipase A2
... X. Group II sPLA2 has been further classified into five subtypes (Type IIA, IIC, IID, IIE, and IIF) on the basis of their primary ...sequences. Group IIA PLA2 is one of the key enzymes in the ...
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Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A2-IIA in microvascular endothelial cells of the injured brain
... IIA protein levels were increased in the media of rat BMVECs after treatment with LPS; (2) secretion of sPLA 2 -IIA from BMVECs was enhanced with the Figure 5 Effects of the inhibitors of iNOS, JAK3, and ...
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Differences between group X and group V secretory phospholipase A2 in lipolytic modification of lipoproteins
... human group X secreted phospholipase A(2) but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian ...
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Purification and biochemical characterization of a secreted group IIA chicken intestinal phospholipase A2
... for phospholipase purification: Sephadex G-50, MonoS sepharose, were from Pharmacia (Uppsala, Sweden); protein sequencer Procise 492 equipped with 140 C HPLC system provided from Applied Biosystems (Roissy, ...
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Cell wall determinants of the bactericidal action of group IIA phospholipase A2 against Gram positive bacteria
... a group IIA phospholipase A 2 (PLA 2 ) is responsible for the potent bactericidal activity of inflammatory fluids against many Gram-positive ...of group IIA PLA 2 ...
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The role of phospholipase A2 in mast cell activation
... The present study has shown that various specific PLA 2 inhibitors, of diverse structural type and working through differing mechanisms, were able to inhibit the release[r] ...
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Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice
... mouse group X sPLA 2 (mGX) is the major enzyme present in the acrosome of spermatozoa and that it is released in an active form during capacitation through spontaneous ...
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Glucocorticoid deficiency increases phospholipase A2 activity in rats
... of group I and II PLA2 were measured by PCR. Group II PLA2 mRNA was increased by 126 +/- 9% in lung tissue of ADX rats, whereas group I PLA2 was increased only by 27 +/- ...in group II mRNA in ...
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Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation
... Figure 4. Contribution of cPLA 2a to eicosanoid synthesis in leukocytes. A ) Eicosanoid levels in whole blood from healthy volunteers or from a patient lacking cPLA 2a treated with LPS ([r] ...
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Cytosolic phospholipase A2 in hypoxic pulmonary vasoconstriction
... The authors thank Clary B. Clish for initial MS-MS analysis, Gudrun Mirick for technical assistance, Yuchiao Chang for statistical advice, and Edward A. Dennis for advice on the phospholipase activity assay. This ...
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Study of the Activity of Phospholipase A2 in Venom of the Transcaucasian Macrovipera Lebetina Obtusa
... More proof to influence ¬ of factors of an environment there are venoms only after drying over steams chloride calcium or after liofils drying. Venom of a cobra, at storage on a cold in the soldered ampoule has kept ...
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Effect of α-lipoic Acid on Hemolytic Activity of Iranian Vipera Lebetina Venom
... 1. Kornalik F. The influence of snake venomes on blood coagulation. Pharmacol Ther. 1985; 29(3): 353-405. 2. Kini RM. Excitement : structure, function and mechanism of snake venom phospholipase A2 ...
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Annexin A2-mediated cancer progression and therapeutic resistance in nasopharyngeal carcinoma
... From 2013, different research teams began to develop ANXA2-targeted therapy. C Ricciardelli’s team used an anti-ANXA2 antibody to reduce both tumor growth and metastasis in an ovarian cancer mice model (SK-OV3) [9]. One ...
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Bactericidal properties of murine intestinal phospholipase A2
... Abstract We purified a molecule from the murine small intestine that killed both Escherichia coli and Listeria monocytogenes, and identified it as intestinal phospholipase A2 iPLA2 by NH[r] ...
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Antibiofilm Activity of Acidic Phospholipase Isoform Isolated from Bothrops erythromelas Snake Venom
... and Phospholipase Activity, following the experiments with the lead author; Elizângela Barros contributed to the research by assisting in the anti-film tests; Taylla Flores contributed by helping with the ...
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