phospholipase C
Cloning and characterization of a novel phospholipase C enzyme, human phospholipase C eta2
... At the resting state, GPCRs are in an inactive conformation and guanine nucleotide diphosphate (GDP) is bound to Gα, which is in a high affinity complex with membrane bound Gβγ. Receptors are activated by ...
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Endothelin stimulates phospholipase C, Na+/H+ exchange, c fos expression, and mitogenesis in rat mesangial cells
... of phospholipase C with increased inositol phosphate turnover and increments of intracellular ...the c-fos protooncogene, additional biochemical signals closely linked to ...
6
The role of phospholipase C signaling in bovine herpesvirus 1 infection
... Bovine herpesvirus 1 (BoHV-1) infection enhanced the generation of inflammatory mediator reactive oxidative species (ROS) and stimulated MAPK signaling that are highly possibly related to virus induced inflammation. In ...
10
Detection of Phospholipase C in Nontuberculous Mycobacteria and Its Possible Role in Hemolytic Activity
... our phospholipase C probe has been based on the comparison between mpcA and mpcB gene sequences from ...the phospholipase C produced by mycobacterial isolates with plc genes homologous to ...
6
Ca2+ Regulation of Trypanosoma brucei Phosphoinositide Phospholipase C
... the presence of one putative phosphoinositide phospholipase C gene (TbPI-PLC1; Tb927.11.5970) (accession no. XP_828672) that is an ortholog of the previously described T. cruzi PI-PLC (TcPI-PLC) gene (7, ...
9
Differential regulation of renal phospholipase C isoforms by catecholamines
... phospholipase C (PLC) activity, but whereas dopamine produces a natriuresis, NE has an antinatriuretic effect. To determine if catecholamines differentially regulate the expression of PLC isoforms, we ...
6
The Correlation between Phospholipase C Epsilon (PLCE1) Gene Polymorphisms and Risk of Gastric Adenocarcinoma in Iranian Population PLCE1 Polymorphism and Gastric Adenocarcinoma
... that Phospholipase C epsilon 1 gene, PLCE1, which is located on chromosome 10q23, participates in cell growth, differentiation and gene expression, as well as induces small GTPases such as Ras, Rap and Rho ...
8
Phosphatidylinositol specific Phospholipase C in Fetal Membranes and Uterine Decidua
... phosphatidylinositol-specific phospholipase C ...phosphatidylinositol-specific phospholipase C activity in human fetal membranes and uterine decidua was identified and ...
11
Advillin acts upstream of phospholipase C ϵ1 in steroid resistant nephrotic syndrome
... by phospholipase C ϵ1 activity is blocked by AVIL ...the phospholipase family of enzymes that catalyzes the hydrolysis of polyphosphoinositides to generate the second messengers ino- sitol-1,4,5 ...
14
Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation
... proliferation. However, the mechanism linking the B lymphocyte antigen receptor to phospholipase C remains to be identified. We demonstrate herein that activation of the antigen receptor on human ...
6
Phospholipase C inhibits apoptosis of porcine primary granulosa cells cultured in vitro
... Phospholipase C (PLC) can participate in cell proliferation, differentiation and ...kinase C β (PKC β ), calmodulin-dependent protein kinaseII α (CAMKII α ) and calcineurinA (CalnA) were decreased by ...
10
The effect of phospholipase C on human blood platelets
... phosphatidylethanolamine, 20-50% phosphatidylcholine, and 20-25% phosphatidylserine. Sphingomyelin was not a substrate for the enzyme under the conditions used. The platelets contained no detectable endogenous ...
8
Identification of a novel class of mammalian phosphoinositol specific phospholipase C enzymes
... Phospholipase C enzymes (PLCs, EC 3.1.4.3) catalyze the cleavage of membrane phospholipids to 1,2-diacylglycerol (DAG) and their respective phosphoryl compound. In mammals, five distinct classes of PLCs ...
5
1,25 dihydroxyvitamin D3 stimulates phospholipase C gamma in rat colonocytes: role of c Src in PLC gamma activation
... kinase C (PKC) isoforms, PKC-alpha and -betaII in the rat large ...polyphosphoinositide-phospholipase C-gamma (PI-PLC-gamma), a predominantly cytosolic isoform of PI-PLC, was involved in ...
12
Phospholipase C mediated hydrolysis of phosphatidylcholine is activated by cis diamminedichloroplatinum(II)
... membrane extract from PC-9 cells. CDDP had no effect on the activities of phospholipase A2 and D. Trans-DDP, which has far less cytotoxicity than its stereoisomer, CDDP, did not cause any change in PC-PLC ...
8
The characterisation of Plc1 : a phospholipase C enzyme identified in the fission yeast Schizosaccharomyces pombe
... catalytic domain, as the PH domain is able to bind PtdIns 3,4,5-P3Garcia et al., 1995 as statedin section 1.2.2.3,PLCs are unableto hydrolyse Ptdlns 3A5-P3The PH domain is not required f[r] ...
224
Biochemical and functional characterisation of phospholipase C η2
... The latest PLC family with two members (PLCη1 and PLCη2) was independently reported in 2005 by four groups. Identification of this distinct PLC group was a result of a screen of the existing sequence databases such as ...
258
Mechanism of Phosphorylation-Induced Activation of Phospholipase C-Gamma Isozymes
... recruited to membranes through docking of the nSH2 domain to a phospho-tyrosine- containing region of a RTK or cytoplasmic tyrosine kinase, but simple recruitment is insufficient to release auto-inhibition and promote ...
182
Regulation of phospholipase C-epsilon by Rho and Ras family proteins
... Song et al. and Lopez et al. identified two human splice variants of PLC-ε differing in the amino-terminal region, yielding sequences of 1994 and 2303 amino acids, respectively [128;129]. Northern blot analysis with ...
155
Regulation of tight junction barrier function by phospholipase C
... myo-inositol at 2 μCi/ml (4 μCi/well; 0.5 ml apical, 1.5 ml basolateral of inositol-free media) for 12 hours at 37°C. Cell media was aspirated from both compartments of Transwell™ inserts, washed twice with HBSS, ...
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