PI3K and influenza A virus replication
Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition
... of PI3K/Akt pathway imparts different effects on virus replication Since NS51 was incompetent to activate PI3K/Akt, we presumed that the activation of the PI3K/Akt signaling pathway may ...
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Heterologous SH3 p85β inhibits influenza A virus replication
... ST364 virus than PR8 ...that influenza A virus varied in their sensitivity to PI3K/Akt pathway due to long-time evolu- ...ST364 virus, PR8 virus was less susceptible to the ...
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Influenza A viruses and PI3K signalling
... rUd virus, rWSN NS1-Y89F did not exhibit an altered phenotype as compared with WT ...of PI3K is necessary for all natural non-laboratory adapted strains of influenza A ...activate PI3K may be ...
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Inhibition of Akt kinase activity suppresses entry and replication of influenza virus
... influenza virus-induced disease has emerged and now appears to be present in a sufficient number of countries to be considered a major global health ...influenza virus replication ...the PI3K–Akt ...
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Sulfatide Is Required for Efficient Replication of Influenza A Virus
... down or enriched cells. Translocation of the newly synthesized NP from the nucleus to the cytoplasm in the cells was also suppressed by anti-H3 HA MAb as well as antisulfatide MAb, which blocks the binding of IAV and ...
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Ceramide Suppresses Influenza A Virus Replication In Vitro
... IAV replication without manipulating SM and GSL ...increased replication of the virus genome (vRNA and cRNA) and synthesis of mRNA transcripts (particularly in Myr-treated cells) at 6 ...genome ...
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Autophagy Promotes Replication of Influenza A Virus In Vitro
... influenza virus minireplicon ...the virus life cycle, NP was observed to be located mainly in the nucleus in both siNC- and siATG5-treated ...viral replication occurs during viral RNA ...
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Infection and Replication of Influenza Virus at the Ocular Surface
... of replication in hu- man ex vivo ocular tissues and corneal or conjunctival cell monolayers, leaving the determinants of ocular tropism ...ity. Replication efficiency, in contrast, was reduced at 33°C ...
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Virus Replication in Enucleate Cells: Vesicular Stomatitis Virus and Influenza Virus
... Enucleate cells, normal cells, and cells which had been exposed to cytochalasin but not centrifuged were infected with either Ao/Bel/42 (B) or fowl plague virus (F) (100 egg infectious u[r] ...
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The NB Protein of Influenza B Virus Is Not Necessary for Virus Replication In Vitro
... the severity of, but are limited in their ability to prevent, viral infection. Clinical trials of cold-adapted live attenuated vac- cines have generated promising results with respect to both efficacy and safety (1, 2, ...
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Engineered Small-Molecule Control of Influenza A Virus Replication
... Safety is also a concern during vaccine challenge studies, which are an important step in the development and testing of novel vaccine and therapeutic strategies against IAV. To reduce the potential for severe disease, ...
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Influenza B Virus Requires BM2 Protein for Replication
... of influenza B virus functions as an ion channel, which is suggested to be important for virus uncoating in endosomes of virus-infected ...a virus possessing the mutant M gene lacking ...
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Human host factors required for influenza virus replication.
... for influenza virus, this creates concern for the development of new influenza ...in influenza virus replication ...by influenza virus in mammalian cells, we have ...
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A Mechanism for Priming and Realignment during Influenza A Virus Replication
... A virus genome consists of eight segments of single- stranded ...influenza virus proteins PB1, PB2, and ...viral replication, the RdRp must use two promoters and two dif- ferent de novo initiation ...
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Chicken cyclophilin A is an inhibitory factor to influenza virus replication
... with influenza virus M1 protein. Cell susceptibility to influenza virus was reduced by over-expression of chCypA in CEF ...recombinant influenza virus A/WSN/33 reduced to one ...
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DNA intercalator stimulates influenza transcription and virus replication
... the influenza viral polymerase complex can inhibit RNAPII transcription elongation, but not initiation [8], a phenomenon that is similar to the tran- scriptional arrest of ...Recently, influenza viral poly- ...
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Saikosaponin A inhibits influenza A virus replication and lung immunopathology
... Fatal influenza outcomes result from a combination of rapid virus replication and collateral lung tissue damage caused by exaggerated pro-inflammatory host immune cell ...of influenza-induced ...
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Evolutionary Targeted Discovery of Influenza A Virus Replication Inhibitors
... ABSTRACT Influenza A is one of the most prevalent and significant viral infections worldwide, resulting in annual epidemics and occasional ...internal influenza A ...reducing influenza A H1N1 ...
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Influenza A Virus M2 Protein Apical Targeting Is Required for Efficient Virus Replication
... Multistep virus growth curves were performed at an MOI of 0.001 in MDCK cells and 0.1 in hNECs. For MDCK cell infections, the inoculum was diluted in IM, added to cells, and allowed to incubate at room temperature ...
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A Bivalent Vaccine Based on a Replication-Incompetent Influenza Virus Protects against Streptococcus pneumoniae and Influenza Virus Infection
... PspA virus) could replicate only in an HA-expressing cell line, it infected wild-type cells and expressed both viral proteins and ...and influenza virus-specific antibodies were detected in nasal ...
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