PI3-kinase
Angiotensin II induces endoplasmic reticulum stress in podocyte, which would be further augmented by PI3-kinase inhibition
... Treatment conditions and preparation of antibodies Mouse podocytes were incubated with various concen- trations of Ang II (Sigma-Aldrich Inc., St. Louis, MO, USA) for 24 h. To inhibit phosphoinositide ...
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Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathways
... protein kinase C (PKC) inhibitor GF109203X, extracellu- lar signal-regulated protein kinase (ERK) inhibitor PD98059 and PI3 kinase inhibitor LY294002 were from Sigma ...
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A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling
... The mutant dl1015 was one of the very early mutants of MT defective in transfor- mation (38, 39). This mutant has been an enigma, because it has been unclear whether it is defective in associations of MT known to be ...
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PI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in hepatocellular carcinoma
... and PI3-kinase (PI3K)/Akt pathways [20], and to inhibit growth and induce apoptosis in both prostate [21] and pancreatic cancers [22]. Recent studies have also shown that lupeol induced apoptosis of HCC ...
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PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients
... distinguish between tumor grades in diffuse gliomas. Our analysis confirms many of the currently used molecu- lar classification schemes for diffuse gliomas: gliomas are first separated based on IDH-mutation status and a ...
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Homocysteine-induced macrophage inflammatory protein-2 production by glomerular mesangial cells is mediated by PI3 Kinase and p38 MAPK
... Homocysteine-induced MIP- 2 is mediated by p38MAPK and PI3 kinase. MCs were incubated (24 hours; 37°C) in the presence of Hcy (50 μM) with or without inhibitors U0126 (p42/44 MAPK inhibitor; 10 μM), ...
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Combining TRAIL with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling
... Our results suggest a mechanism by which PI-103 and 17-AAG increased sensitivity of colorectal cancer cells to TRAIL involving amplification of the TRAIL apoptotic signal through the decreased expression/ activation of ...
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Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in 12 V-Ha-Ras transgenic mouse glioma model
... the PI3-kinase/AKT path- way has been implicated in different brain tumors ...of PI3-kinase pathway has been studied in the biopsy samples from GBM patients ...of PI3-kinase in ...
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PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors
... blood homeostasis. Specifically, minimal levels of Epo which lead to a basal activation of the MEK and Erk kinases moderately activate the class Ib PI3 kinase isoform PI3Kγ. This is, to our knowledge, the ...
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FGF and PI3 kinase signaling pathways antagonistically modulate sex muscle differentiation in C elegans
... the PI3 kinase signaling pathway, which functions to promote ...the PI3 kinase signaling components PDK1 and AKT1 can result in myoblast differentiation even in the presence of an FGF signal ...
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A Stabilized Demethoxyviridin Derivative Inhibits PI3 kinase
... The reaction of the C1 OH of Dmv to form SA-Dmv produced a significant improvement in stability in PBS and in PBS with amino acids added (Table 1). Since the C1 of Dmv does not appear to participate in resonance ...
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The effect of dietary red palm oil on the functional recovery of the ischaemic/reperfused isolated rat heart: the involvement of the PI3-Kinase signaling pathway
... the PI3-K pathway in RPO-induced protection with the aid of an inhibitor (wortmannin); and (iii) to evaluate apoptosis in our ...the PI3-Kinase signaling pathway and apoptosis in our ...attenuated ...
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PI3 kinase mutation linked to insulin and growth factor resistance in vivo
... SHORT syndrome is an autosomal dominant disorder, which was originally characterized as a condition of short stature, hyperextensibility of the joints and/or hernia, ocular depression, rieger anomaly, and teething delay ...
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Promotion of human mesenchymal stem cell osteogenesis by PI3-kinase/Akt signaling, and the influence of caveolin-1/cholesterol homeostasis
... Cav-1 probably dampens pro-osteogenic signaling by sequestering signaling mediators in cell surface caveolae and/or driving their internalization via caveolae endocytosis. In accordance with this idea, caveolae ...
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Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase
... Acute myeloid leukemia (AML) is a highly fatal disease, as many patients do not respond to therapy or eventually relapse [1-3]. For older patients or patients with co-morbities who cannot tolerate intensive chemotherapy, ...
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Molecular Mechanism behind Rotavirus NSP1-Mediated PI3 Kinase Activation: Interaction between NSP1 and the p85 Subunit of PI3 Kinase
... P hosphoinositide 3-kinases (PI3Ks) regulate an array of pro- tein kinase signaling cascades that, in turn, control diverse cellular processes like cell survival, metabolism, proliferation, and ...
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Active β-catenin is regulated by the PTEN/PI3 kinase pathway: a role for protein phosphatase PP2A
... An increasing body of evidence suggests that deregulation of the PI3K pathway is strategically used by tumors to attain growth advantage and survival [18]. Interestingly, perturbation of the tumor suppressor PTEN, ...
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Deficiency of PI3-Kinase catalytic isoforms p110γ and p110δ in mice enhances the IL-17/G-CSF axis and induces neutrophilia
... increased production and release of neutrophils from the BM. G-CSF is the principal growth factor directly regulating the proliferation and differentiation of neutro- phils [3, 4], but it also modifies neutrophil ...
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Key signalling nodes in mammary gland development and cancer Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts
... kappa-B kinase (IKK), resulting in IKK activation and phosphorylation of IκB ...mTOR-Raptor kinase complex, which in turn mediates phosphorylation of 4E-BP1 (eukaryotic translation initiation factor ...
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Modulating effect of the PI3-kinase inhibitor LY294002 on cisplatin in human pancreatic cancer cells
... Currently, gemcitabine is regarded as the standard and only efficacious chemotherapeutic agent for advanced pancreatic cancer, even though it shows modest results and limited survival benefit [1-3]. When the first line ...
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