PI3K/AKT/ERK
Inhibition effects of patchouli alcohol against influenza a virus through targeting cellular PI3K/Akt and ERK/MAPK signaling pathways
... Cellular PI3K/Akt signaling pathway is known to be able to augment replication of several viruses, and may be associated with lytic infections of both RNA and DNA viruses, including influenza A virus ...of ...
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Original Article PAR-2 promotes invasion and migration of esophageal cancer cells by activating MEK/ERK and PI3K/Akt signaling pathway
... and PI3K/Akt path- ways were suppressed in PAR-2 gene silenced cells, but were enhanced in PAR-2 activated ...and PI3K/Akt signaling pathways could significantly promote malignant tumor ...
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Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways
... of PI3K/AKT and Ras/MAPK/ERK, which are associated with various protein kinase cascades, contrib- ute to tumor growth in malignant glioblastoma [8, 9, ...of AKT and ERK pathways were ...
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HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways
... Purinergic P2 receptor family includes P2Y1R, P2Y2R, P2Y4R, P2Y6R, P2Y12R, and P2Y14R that express in CNS astrocytes [31, 32]. Recent data have demonstrated that ATP is recognized to act through purinergic P2 receptors ...
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Original Article Advanced glycation end products upregulates the expression of connexin43 via ERK MAPK and PI3K/Akt pathways in human endothelial cells
... of ERK, P38, and JNK mitogen-activated protein kinases (MAPKs), which are supposed to participate in the regulation of ...both Akt and PKC phos- phorylation were time-dependently augmented by AGE-BSA and ...
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Natural product pectolinarigenin inhibits proliferation, induces apoptosis, and causes G2/M phase arrest of HCC via PI3K/AKT/mTOR/ERK signaling pathway
... reduced PI3K, p-AKT, p-mTOR, and p-ERK1/2 protein levels (Figure 4) in both SMMC7721 and PLC5 ...through PI3K/AKT/ mTOR/ERK signaling pathway and suggested that it may be an alternative ...
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Endogenous Endothelin 1 Regulates Hypoxia Induced Atrial Natriuretic Peptide Secretion by Activating the MAPK/ERK and PI3K/Akt Signaling Pathways in Isolated Beating Rabbit Atria
... hypoxia-induced ANP secretion. Both antagonists significantly attenuated the levels of hypoxia- induced atrial phosphorylated (p)-extracellular signal-regulated kinase (ERK) and p-protein ki- nase B (Akt). ...
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Opposite regulation by PI3K/Akt and MAPK/ERK pathways of tissue factor expression, cell-associated procoagulant activity and invasiveness in MDA-MB-231 cells
... through PI3K/Akt and JNK pathways ...the ERK inhibitors U0126 and PD98059 had been observed in breast cancer cells and LPS-stimulated human monocytic cells ...and PI3K pathways depend on the ...
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Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway
... clinical responses in melanoma patients with the BRAF mutation, most patients appear to eventually relapse [32]. Our results showed that Dtx3l/DTX3L-mediated regulation of melanoma metastasis is dependent on the ...
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Phosphatidylinositol 3-Kinase/Akt and MEK/ERK Signaling Pathways Facilitate Sapovirus Trafficking and Late Endosomal Acidification for Viral Uncoating in LLC-PK Cells
... of PI3K/Akt and MEK/ERK signaling pathways by PSaV and bile ...of PI3K/Akt and MEK/ERK signaling ...of PI3K, Akt, ERK, pPI3K p85 (Tyr458)/p55 (Tyr199), pAkt ...
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Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target
... targeting PI3K/AKT pathway, L-744832 targeting RAS, PD98059 targeting ERK/MAPK signaling and AG1296 targeting FLT3, the authors found that NF- κB DNA-binding activity was inhibited only by RAS and ...
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TWEAK/Fn14 interaction regulates RANTES production, BMP 2 induced differentiation, and RANKL expression in mouse osteoblastic MC3T3 E1 cells
... Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), a member of the TNF family, is a multifunctional cytokine that regulates cell growth, migration, and survival principally through a TWEAK receptor, ...
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Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer
... of PI3K-AKT signaling that was required for continued cell ...of PI3K-AKT and sustained motility following inhibition of the Ras-ERK in LM2 and BrM2 ...
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STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways
... pAKT, PI3K and Ras were remarkably increased either in NCM460 cells transfected with STC2 plasmids or in cells induced with exogenous STC2 ...blocking AKT-ERK signaling pathways attenuated ...
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Original Article The PK3K/AKT and ERK/MAPK signaling pathways correlate with nasopharyngeal carcinoma
... the PI3K/AKT and ERK/MAPK signal transduction pathways in the proliferation and apoptosis of malignant ...the PI3K/AKT and ERK/MAPK signal pathways in nasopharyngeal carcinoma is ...
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The combination of Biochanin A and SB590885 potentiates the inhibition of tumour progression in hepatocellular carcinoma
... the ERK/AKT/mTOR signalling pathway ...to ERK activity ...the AKT inhibitor ZSTK474 impacted the proliferation of papillary thyroid cancer cell lines by inhibiting the ERK MAPK and ...
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Novel naphthochalcone derivative accelerate dermal wound healing through induction of epithelial-mesenchymal transition of keratinocyte
... for PI3K/ AKT/mTOR and MAPK (ERK) are reported to be involved in the regulation of EMT [2, ...of AKT has been implicated in the induction of the EMT and cell migration ...
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Integrin β1 Mediates Vaccinia Virus Entry through Activation of PI3K/Akt Signaling
... V accinia virus is the prototype of the orthopoxvirus genus of the family Poxviridae. It has a broad host range, producing multiple infectious forms of virus particles, e.g., mature virus (MV), wrapped virus (WV), and ...
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miR-671-5p Blocks The Progression Of Human Esophageal Squamous Cell Carcinoma By Suppressing FGFR2
... and PI3K/AKT signaling pathways [10], and FGFR2 enhances the phosphorylation activity of RSK2 and regulates the migration of human mammary epithelial cells ...
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Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression
... and PI3K/AKT signaling pathways in TKI resistant lung adenocarcinoma cells occurred through an EGFR-independent ...activate PI3K/AKT signaling pathway to confer TKI resistance in lung ...
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