PI3K/Akt/mTOR
PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs
... With regard to cellular regulation (migration, differenti- ation, proliferation, growth or survival of cells), PDGFR downstream-signalling mainly activates two pathways: 1) the MAPK-pathway and 2) the ...
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Original Article On the in vitro anti-myeloma effect and mechanism of Andrographolide through PI3K/AKT/mTOR and AMPK/mTOR dual signaling pathways
... pathway PI3K/AKT/ mTOR, as well as mediate MM cell proliferation and drug-resistance ...[20]. PI3K/AKT/mTOR is an important pathway to facilitate cell prolifera- tion in myeloma, ...
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The PI3K-AKT-mTOR pathway activates recovery from general anesthesia
... of PI3K-AKT-mTOR pathway in recovery from general ...and PI3K/Akt agonists (Group ...of PI3K-AKT-mTOR pathway were measured by RT-qPCR and Western ...in ...
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IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways
... the PI3K/AKT/FOXO1 pathway. In the same manner, p-AKT and p-FOXO1 were detected to be markedly decreased in IMPDH2-silenced CRC cells, but increased in IMPDH2-overexpressed CRC ...more, AKT ...
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Plumbagin induces G<span style="font-size: 8.3333330154419px">2</span>/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
... In addition, we have observed that PLB induced both apoptosis and autophagy in SCC25 cells, and that PLB can induce autophagy at a lower concentration and over a shorter time period. We predict that autophagy may be much ...
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Sinomenine inhibits the growth of melanoma by enhancement of autophagy via PI3K/AKT/mTOR inhibition
... affects PI3K/Akt/mTOR activation in melanoma ...of Akt and mTOR. IGF-1 is a well-known PI3K signaling activator that plays an important role in the regulation of cell ...
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Original Article The exosome-mediated PI3k/Akt/mTOR signaling pathway in cervical cancer
... the PI3k/Akt/mTOR signaling pathway in cancer tissues and exosomes extracted from vaginal ...of PI3k, Akt, and mTOR in tissue samples from the control group, the CIN (cervical ...
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Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas
... The PI3K/AKT/mTOR signaling pathway has emerged as the most frequently mutated mitogenic pathway in HNSCC (31%) with multiple actionable targets, representing an excellent opportunity to develop more ...
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Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs
... that PI3K inhibition has on glucose homeostasis remains to be ...of PI3K/Akt/mTOR inhibitors that could potentially be used as PD biomarkers include hypertriglyceridemia and hyperglycemia ...
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PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma
... exhibiting PI3K/AKT/mTOR dysregulation [12–16]. The PI3K/AKT/mTOR pathways are activated by receptor tyrosine kinases (RTK) that transmit extracellular signals from the tumor ...
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Hyperglycemia and Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) Inhibitors in Phase I Trials: Incidence, Predictive Factors, and Management.
... Our study is the largest examination of the patients treated with PI3K-AKT-mTOR inhibitors on various clinical trials. We found that the incidence of clinically significant hyperglycemia (>grade ...
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Identification of mutations in the PI3K-AKT-mTOR signalling pathway in patients with macrocephaly and developmental delay and/or autism
... At the time when genetic counselling was provided to patients with mutations, patients were re-examined to determine whether they had features of PTEN hamar- toma tumour syndrome [40] such as macular pigmenta- tion of ...
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Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice
... the AKT/mTOR signal- ing pathway and down-regulation of caspase-3 in rats sub- jected to phototrombic stroke ...through PI3K/AKT/mTOR pathway, thus such protective mechanism might ...
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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
... Though more and more PI3K/Akt/mTOR targeted drugs emerge, they are still undergoing preclinical or clinical trials. Targeted therapy for GBM has yet to demonstrate an appreciable clinical survival ...
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Original Article NRSN2 promotes non-small cell lung cancer cell growth through PI3K/Akt/mTOR pathway
... As PI3K/Akt/mTOR pathway plays a key role in NSCLC cell growth [11], we examined the effect of NRSN2 silencing and over-expressing on the expression of phosphorylated Akt and phos- phorylated ...
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The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines
... subtypes), mTOR and PTEN, which function in the PI3K/AKT/mTOR pathway, were selected for further validation of the RNA-Seq ...GPCR, mTOR and PRKCB expression was increased but that ...
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Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress- mediated survival of melanoma cells
... Cancer cell properties like increased proliferative capacity and anchorage-independent growth are mediated in part through PI3K/AKT/mTOR signaling, which controls cell growth through protein ...
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Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway
... the PI3K/Akt/mTOR pathway via RAGE, while blockage RAGE re-activated PI3K/Akt/ mTOR pathway, however, the addition with PI3K inhibitor redeuced the cell autophagy and ...
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Original Article Prostaglandin transporter, SLCO2A1, mediates the invasion and apoptosis of lung cancer cells via PI3K/AKT/mTOR pathway
... In summary, SLCO2A1 exhibits the ability to mediate the invasion and apoptosis of lung cancer cells, possibly via regulating PI3K/AKT/ mTOR pathway. Knockdown of SLCO2A1 can inhibit lung cancer cell ...
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Natural product pectolinarigenin inhibits proliferation, induces apoptosis, and causes G2/M phase arrest of HCC via PI3K/AKT/mTOR/ERK signaling pathway
... Materials and methods: HCC cell lines SMMC7721 and PLC5 were cultured and treated with indicated concentrations of pectolinarigenin. For the HCC cell proliferation, after HCC cells were stimulated with indicated ...
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