PI3K/Akt/mTOR pathways
<p>LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma</p>
... and PI3K/Akt/mTOR path- ways, we detected the combination of LSD1 with the promo- ter regions of Notch pathway targets Notch3, Hes1, DTX1 and CR2 by ChIP ...the PI3K/Akt/ mTOR ...
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PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma
... Sarcomas are a diverse group of malignant mesenchymal neoplasms with over 50 histologically distinct subtypes [1]. They can be broadly classified in two groups: those containing simple karyotypic defects including recur- ...
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The expression of the PI3K/AKT/mTOR pathway in gastric cancer and its role in gastric cancer prognosis
... the PI3K/AKT/mTOR pathways is correlated with gastric cancer tumorigenesis and ...activating PI3K mutations may be present in Epstein–Barr virus-associated gastric cancers and may be a ...
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Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways
... proliferation. PI3K/Akt activation occurs at immediate growth factor supplement and late G1 phase of the cell ...G1 PI3K/Akt activity leads to a decrease of c-Myc expression levels because of ...
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Exome Sequencing Identifies Potentially Druggable Mutations in Nasopharyngeal Carcinoma
... cancer pathways (Fig. 6). The most affected pathways include the DNA repair ...EGFR/ PI3K/Akt/mTOR ...these pathways, irrespective of germline or somatic, may potentially serve ...
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Original Article Endogenous SARI exerts oncogenic functions in human K562 leukemia cells by targeting the PI3K/Akt/mTOR and NF-κB signaling pathways
... of mTOR, p-mTOR, p-PI3K, p-Akt, p70-S6K, p-p70-S6K and c-myc were dramatically decreased in SARI knock- down K562 cells, suggesting that SARI may function as a crucial protein in modulating ...
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miR-185 suppresses progression of Ewing’s sarcoma via inhibiting the PI3K/AKT and Wnt/β-catenin pathways
... After 48 hours of transfection, cells were harvested and lysed with ice-cold RIPA Lysis Buffer (CWBIO) at 4 ° C to extract proteins, and the protein concentration was measured using a BCA Protein Assay Kit (Beyotime, ...
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Original Article 17β-estradiol activates mTOR in chondrocytes by AKT-dependent and AKT-independent signaling pathways
... of PI3K could only partly influence the activation of mTOR by E2, demon- strating that E2 activates mTOR independently through PI3K-AKT-mTOR, there might be other involved ...and ...
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Panax notoginseng saponins promote liver regeneration through activation of the PI3K/AKT/mTOR cell proliferation pathway and upregulation of the AKT/Bad cell survival pathway in mice
... and pathways were involved in these mechanisms, including membrane transporters, protein chaperones, antioxidant enzymes, growth fac- tors, and signaling pathways and transcriptional factors ...[28]. ...
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Progesterone Induces NFκB DNA Binding Activity through a PI3K/Akt-Dependent Pathway in MCF-7 Breast Cancer Cells
... signaling pathways, including the activation of PDK and Akt. The Akt family of serine-threonine kinases is the primary downstream mediator of PI3K, and through the phosphorylation of target ...
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MicroRNAs in the Occurrence and Development of Primary Hepatocellular Carcinoma
... ular pathways, including p53, RAS/MAPK, PI3K/ Akt/mTOR, Wnt/β-cateninβ, MET, Myc gene, transforming growth factor-β, resulting in molecu- lar genetic and epigenetic histological ...
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IMPDH2 promotes colorectal cancer progression through activation of the PI3K/AKT/mTOR and PI3K/AKT/FOXO1 signaling pathways
... the PI3K/AKT/FOXO1 pathway. In the same manner, p-AKT and p-FOXO1 were detected to be markedly decreased in IMPDH2-silenced CRC cells, but increased in IMPDH2-overexpressed CRC ...more, AKT ...
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Targeting the PI3K/Akt/mTOR Signaling Pathway: Applications of Nanotechnology
... (9). mTOR is involved in a pathway, known as PI3K/Akt/mTOR signaling pathway that regulates cellular growth behaviors which has the potential to lead to ...that mTOR does its function ...
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Original Article The exosome-mediated PI3k/Akt/mTOR signaling pathway in cervical cancer
... Cervical cancer, as the second most common cancer, is a malignant tumor originating from the squamocolumnar junction of the cervix. It is one of the leading causes of cancer deaths in women, especially among cancers that ...
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Original Article On the in vitro anti-myeloma effect and mechanism of Andrographolide through PI3K/AKT/mTOR and AMPK/mTOR dual signaling pathways
... pathway PI3K/AKT/ mTOR, as well as mediate MM cell proliferation and drug-resistance ...[20]. PI3K/AKT/mTOR is an important pathway to facilitate cell prolifera- tion in myeloma, ...
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Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress- mediated survival of melanoma cells
... Reactive oxygen species (ROS) are important signaling molecules that are generated as by-products of cellular metabolism and eliminated by antioxidant defense mechanisms in part through the KEAP1/NRF2 pathway [4]. The ...
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PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
... the PI3K/Akt(PKB)/mammalian target of rapamycin (PI3K/Akt[PKB]/mTOR) pathway (2, ...in PI3K p100 catalytic subunit α (PIK3CA) occur in more than 30% of solid tumors, leading to ...
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Zuo Jin Wan reverses P gp mediated drug resistance by inhibiting activation of the PI3K/Akt/NF κB pathway
... In conclusion, based on our previous clinical and experi- mental studies, ZJW can be used as an inhibitor of che- moresistance in CRC. The present investigation has shown that the anti-MDR activity of ZJW can be par- ...
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Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs
... in PI3K mutated xenograft models of human ...unknown PI3K pathway status; and a patient with Cowden’s syndrome (germline PTEN mutation) who had developed lung ...
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Hyperglycemia and Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) Inhibitors in Phase I Trials: Incidence, Predictive Factors, and Management.
... Our study is the largest examination of the patients treated with PI3K-AKT-mTOR inhibitors on various clinical trials. We found that the incidence of clinically significant hyperglycemia (>grade ...
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