PI3K/AKT pathway
The PI3K/Akt Pathway Contributes to Arenavirus Budding
... (PI3K)/Akt pathway, known to regulate a variety of cellular processes, including cell growth, proliferation, survival, and me- tabolism (14), has also been involved in the regulation of cell entry ...
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PI3K/Akt pathway: a potential therapeutic target for chronic pain
... the PI3K/Akt pathway [49, ...that Akt can positively regulate the Raf/MEK/ERK pathway at the level of B-Raf ...an Akt-ERK crosstalk pathway ...of PI3K attenuates ...
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RICTOR involvement in the PI3K/AKT pathway regulation in melanocytes and melanoma
... the PI3K pathway is frequently over-activated in melanoma via multiple ...of PI3K [25, 26] and AKT3 [27], the predominant AKT isoform in melanoma [28], have also been ...Increased AKT ...
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CAV2 promotes the growth of renal cell carcinoma through the EGFR/PI3K/Akt pathway
... EGFR/PI3K/Akt pathway has an important role in ...EGFR, PI3K and Akt using an online tool ...EGFR, PI3K and Akt (Figure ...EGFR, PI3K and p-Akt in OS-RC-2 ...
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APLN promotes hepatocellular carcinoma through activating PI3K/Akt pathway and is a druggable target
... identifies PI3K/Akt as the major downstream signaling mechanism underlying the oncogenic effect of APLN in ...activates PI3K/Akt pathway and induces phosphorylation of PI3K p85, ...
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JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer
... the PI3K/AKT pathway. Activation of PI3K/AKT pathway has been shown to be responsible for loss of PTEN function induced drug ...targeting PI3K and mTOR pathway were ...
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Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway
... through Akt/p-Akt signaling pathway [27]. Akt/protein kinase B (PKB) belongs to the downstream molecules of PI3K, which plays an important role in PGE2-EP4 pathway, as shown ...
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Nck1 depletion induces activation of the PI3K/Akt pathway by attenuating PTP1B protein expression
... the PI3K/Akt pathway in a protein tyrosine phosphatase 1B (PTP1B)-dependent ...enhances PI3K-dependent basal and growth factor-induced Akt ...enhanced Akt activation in response ...
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Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway
... the PI3K/Akt pathway resulting from genetic mutations and epigenetic deregulation of its major regulators is known to cause resistance of melanoma to therapeutic agents, including the conventional ...
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Influenza A Virus NS1 Protein Activates the PI3K/Akt Pathway To Mediate Antiapoptotic Signaling Responses
... the PI3K/Akt pathway ...the PI3K/Akt pathway, although activated by dsRNA, re- mained silent rather than being activated upon infection by delNS1 ...of PI3K and which ...
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TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway
... inhibiting Akt activation would prevent the protective effects of rTSLP ...treatment. Akt inhibition with Ly294002 has been shown to exacerbate liver damage during liver I/R injury ...Phosphorylated ...
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The PI3K/AKT pathway in obesity and type 2 diabetes
... the PI3K/AKT pathway ...results, AKT may not only be an indispensable intermediate for insulin action, extrahepatic insulin may be stimulated by other pathways to regulate glucose metabolism ...
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Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway
... Although several studies have demonstrated the gen- eral hematopoietic activity of APS, no study has been performed to specifically determine its thrombopoietic effects. In addition, the mechanism of action of APS’s ...
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Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway
... with Akt and increase the phosphorilation of Akt. Phosphor-Akt can stimulate the transactivation of the p65 subunit of NF-κB through the IκB ...the Akt pathway was ...the Akt ...
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LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway
... of PI3K signaling cascade ...of AKT and p-AKT was significantly higher in NSCLC tissue with KRAS mutation compared to those with wild-type KRAS [51, ...The PI3K/AKT pathway is ...
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SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway
... and PI3K/Akt/mTOR signaling pathways ...(PI3K)/Akt pathway is a classical and important signaling pathway involved in numerous cellular functions, including cell proliferation, ...
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Effect of PI3K/Akt Signaling Pathway on PRAS40Thr246 Phosphorylation in Gastric Cancer Cells
... against AKT inhibitors. The clinical application of PI3K/AKT inhibitors, and can accurately indicate the activation state of PI3K/AKT pathway ...and PI3K/AKT ...
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Targeting the PI3K/Akt/mTOR Signaling Pathway: Applications of Nanotechnology
... a pathway, known as PI3K/Akt/mTOR signaling pathway that regulates cellular growth behaviors which has the potential to lead to ...from AKT, while mTORC2 controls AKT activity ...
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Effect of nicastrin on hepatocellular carcinoma proliferation and apoptosis through PI3K/AKT signalling pathway modulation
... the PI3K/ Akt and P53/caspase3 pathways in fibroblasts, human cells and neurons ...regulates Akt activation in breast cancer cells and that NCSTN inhibition in malignant breast cells can inhibit ...
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Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma
... the pathway enrichment analysis, we identified PI3K/AKT signaling pathway was involved in both HCC cell lines ...the PI3K/AKT pathway, which, however, could be effectively ...
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