Pilocytic astrocytoma
Genetic changes observed in a case of adult pilocytic astrocytoma revealed by array CGH analysis
... Array comparative genomic hybridization (aCGH) is a modern technique for detecting gene copy number variation across the entire genome. It is a reliable and sensitive method and has been widely used in genetic profiling ...
8
Case Report Pilocytic astrocytoma with angiocentric arrangement: pathological features and differential diagnostic
... of pilocytic astrocytoma are with large number of myxoid background, bipolar spindle tumor cells arrang- ed with radial around tumor cells vascular cen- ...of pilocytic astrocytoma, and ...
6
Stereotaxic gamma knife surgery in treatment of critically located pilocytic astrocytoma: preliminary result
... are pilocytic astrocytoma, low-grade astrocyto- mas, oligodendrogliomas, and mixed oligo-astrocytomas located more often in the posterior fossa, optic pathway, and brain stem and less commonly in the ...
6
Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age
... Pilocytic astrocytoma (PA) is a World Health Organization (WHO) grade I astrocytoma and the most common pediatric brain tumor [1, 2]. These tumors generally have an excellent prognosis and limited ...
13
An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice
... Pilocytic astrocytoma (PA) is the most common primary brain tumor in children. This WHO grade I neoplasm characteristically displays noninfiltrative growth and shows benign biological behav- ior that ...
6
Constitutional chromosomal events at 22q11 and 15q26 in a child with a pilocytic astrocytoma of the spinal cord
... We present the clinical features of a 9-years-old male harbouring two paternally inherited events – a short 22q11.23 deletion and a 15q26.3 duplication – and a de novo 1.5 Mb deletion at 22q11.2 band. The child devel- ...
5
Case Report IDH1 R132H mutation in a pilocytic astrocytoma: a case report
... Pilocytic astrocytoma is the most common pri- mary brain tumor in ...in pilocytic astrocytomas and together with KIAA1549-BRAF fusion tran- script analysis, resulting from a somatic dupli- cation of ...
5
A novel GIT2-BRAF fusion in pilocytic astrocytoma
... 9. DTW J, Hutter B, Jager N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang D, Fontebasso AM, Stutz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Cin HS, Witt H, ...
6
Manifestations of pilocytic astrocytoma: a pictorial review
... within pilocytic tumours might be explained by several mechanisms, such as an abnormal number or dysfunction of mitochondria (which would interfere with the processes of oxidative phosphorylation and electron ...
16
MR imaging features of spinal pilocytic astrocytoma
... Cerebellum PA are known to enhance, typically in- tensely [23]. The contrast enhancement of PA is thought to be due to the unique vascular wall of the tumor, in which endothelial cells have open tight junc- tions and ...
8
Novel BRAF Alteration in a Sporadic Pilocytic Astrocytoma
... this pilocytic astrocytoma, RNA was extracted from a snap-frozen tumor specimen using the RNeasy mini-kit (QIAGEN), reverse transcribed, and amplified by PCR using BRAF and KIAA1549 primers as previously ...
5
The use of early postoperative MR in detecting residual juvenile cerebellar pilocytic astrocytoma
... of benign and malignant tumors in different locations, eight of whom had cerebellar astrocytomas. All the patients in this study had undergone contrast-en- hanced CT within 72 hours of tumor resection. En- hancement was ...
6
Evidence for new targets and synergistic effect of metronomic celecoxib/fluvastatin combination in pilocytic astrocytoma
... Pilocytic astrocytomas (PA) are the most frequent gliomas in childhood. According to the World Health Organization, most of them are grade I and are character- ized by an excellent prognosis. PA arise ...
14
TP53 codon 72 polymorphism may predict early tumour progression in paediatric pilocytic astrocytoma
... them, pilocytic astrocytomas (PAs) are the predominant pathological subtype, followed by mixed neuronal and glial tumours, such as gangliogliomas (GGs) and desmoplastic infantile gangliogliomas ...
9
Identification of transcriptional regulatory networks specific to pilocytic astrocytoma
... Multiple studies have identified individual gene tran- scripts that are differentially expressed in PA relative to other malignant and non-malignant cell populations [4]. In the current study, we identified 792 genes ...
9
Juvenile Pilocytic Astrocytomas: CT and MR Characteristics
... 7.- T1-weighted axial, 600/17 A, and T2weighted coronal, 2000/ 90 8, MR images show right optic nerve pilocytic astrocytoma with posterior extension into optic chiasm.. Tumor is hypointe[r] ...
8
Development of a pre operative scoring system for predicting risk of post operative paediatric cerebellar mutism syndrome
... Total n Col% Age Mean±SD 9.7±5.0 Median IQR 8.9 8.4 Gender Male 28 31% Female 61 69% Pre-operative radiological diagnosis Ependymoma 12 13% Medulloblastoma 36 40% Pilocytic astrocytoma 4[r] ...
36
Tanycytomas: A Newly Characterized Hypothalamic Suprasellar and Ventricular Tumor
... classic pilocytic astrocytoma, our tumors occurred in pediat- ric and adult patients and in the pediatric cases, were very aggressive neoplasms leading to less favorable ...the pilocytic ...
6
Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas
... Eight patients ranging in age from 1 to 12 years (mean, 6.8 6 2.6 years) were studied. All patients had MR images showing brain tumors in the region of the cerebellum, and subsequent pathologic analysis of surgical ...
6
IMMUNOHISTOCHEMICAL EXPRESSION OF CLUSTER OF DIFFERENTIATION-68(CD-68) AND KI-67 IN ASTROCYTOMAS
... of pilocytic astrocytoma as it has good prognosis and decrease the immunity in ascending grades of astrocytoma that explain their virulent nature and aggressive ...
11