PIM kinase
AZD1208, a Pan-Pim Kinase Inhibitor, Has Anti-Growth Effect on 93T449 Human Liposarcoma Cells via Control of the Expression and Phosphorylation of Pim-3, mTOR, 4EBP-1, S6, STAT-3 and AMPK
... of Pim-1, Pim-2 and Pim-3, are active serine (S)/threonine (T) kinases which are highly homologous with overlapping functions and substrate specificities ...S6 kinase (p70S6K), signal ...
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PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells
... The PIM family of oncogenic serine/threonine kinases regulates tumour cell ...by PIM kinases we analyzed gene expression differences in DU-145 and PC3 prostate cancer derived cells induced by treatment with ...
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Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress
... of Pim kinases sensitizes cells with FLT3-ITD to apoptosis induction by topoisomerase 2 inhibitors through increased ROS generation, in that marked increase in ROS is seen and enhanced apoptosis induction is ...
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Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry
... Since Pim kinase family members share sequence homol- ogy with overlapping functions (12), we hypothesized that stabil- ities of other Pim kinases might also be regulated by NS5A protein in ...
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Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447
... also shows promise for ABC-DLBCL but so far has been assessed only in heavily pre-treated relapsed/refractory patients [52]. Ibrutinib’s target BTK sits downstream of BCR activation and upstream of the CBM complex. It ...
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Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110 inhibition
... pan PIM kinase inhibitors were obtained from Selleckchem (Houston, TX) and AstraZeneca (Wilmington, DE), ...PI3 kinase inhibitor, exhibiting specificity towards the p110α subunit of PI3 ...
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Intrinsic resistance to PIM kinase inhibition in AML through p38α-mediated feedback activation of mTOR signaling
... therapies. PIM kinases are often overexpressed in AML and DLBCL and are therefore an attractive therapeutic ...to PIM inhibition is ...agent PIM inhibitor ...the PIM kinase inhibitor ...
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Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas
... of PIM kinases was assessed in different BCL cell lines by western blot after nuclear-cytoplasmic ...various PIM kinase inhibitors on NHL cell ...
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Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice
... of Pim kinases in HSCs were not previously reported are: 1) Previous studies had been focused on the effects of Pim kinases on T- and B- ...2) Pim- deficient mice were generated on FVB/J background ...
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Pim1 kinase regulates c-Kit gene translation
... duel kinase inhibitor) or GNE652 (a pan-Pim kinase inhibitor) resulted in reduced level of c-Kit expression in Molm-16 cells by west- ern immunoblot ...of Pim, was used to validate the ...
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PIM 2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity
... PIM kinase family members play a crucial role in promoting cell survival and proliferation via phosphorylation of their target ...the PIM kinases with respect to T cell responses in transplantation ...
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The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression
... pan-Pim kinase inhibitor or PIM1 siRNA has been shown to block mTORC1 activity by stimulating the phosphorylation and thus activation of AMPK ...of PIM [44], and several studies demonstrated the ...
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PIM kinases as therapeutic targets against advanced melanoma
... The PIM (provirus integration site for moloney murine leukemia virus) family of serine/threonine kinases is composed of three isoforms, PIM1, PIM2, and ...i.e. PIM kinase activity depends on protein ...
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MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine
... that Pim-3 is important for cell growth, apoptosis, and cell-cycle progression in human pancreatic cancer [16], although miR-124 targets Pim-3 in glioblastoma stem cells ...this kinase. The ...
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... vitro kinase assay, the immunoprecipitants were incubated with ...Pim1 kinase in the presence of ATP and then subjected to Western blot analysis with anti-phospho S1101 IRS1 ...identical Pim ...
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<p>PIM-1 kinase: a potential biomarker of triple-negative breast cancer</p>
... The PIM-1 (provirus integration site for Moloney murine leukemia virus 1) gene was identi fi ed as an oncogene in mice with leukemia induced by the Moloney murine leukemia virus in ...1 PIM-1 kinase, ...
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Can generic paediatric mortality scores calculated 4 hours after admission be used as inclusion criteria for clinical trials?
... the PIM score appears superior to the PRISM and PRISM III scores. PIM score takes into account the condition of the patient directly on arrival in the PICU ...
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Overexpression of Pim-1 in bladder cancer
... the Pim-1 protein has been reported in hematolymphoid malignancies and solid cancers ...[4,5]. Pim-1 has been asserted to promote tumorigenesis through multiple mechanisms, including its interaction with ...
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Automatic generation of data merging program codes
... a PIM in the context of MDA since it describes the necessary aspects of the application independently of the platform on which it will be implemented and executed (Kleppe et al, ...
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IGMP for IPTV pdf
... In addition, they support extensive capabilities to enhance delivering IPTV service, including: • Multicast router for IPv4 and IPv6 supporting PIM-SSM, PIM-SM and MBGP • Support for IGM[r] ...
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