PINK1/Parkin-mediated Mitophagic cell death
Zinc oxide nanoparticles induce toxicity in CAL 27 oral cancer cell lines by activating PINK1/Parkin-mediated mitophagy
... Mitophagy is a critical process that maintains a healthy and functional mitochondrial network that responds to physi- ological adaptations and stress conditions during develop- ment, as well as throughout life. 14 Based ...
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Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging.
... of cell death upon differentiation in Pink1/Parkin knockdown ...or parkin RNAi ) groups ...the Pink1/Parkin knockdowns ...clone cell numbers observed upon ...
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The PINK1/Parkin pathway: a mitochondrial quality control system?
... that Parkin plays a post-fission role in mitochondrial turnover could be explained by a molecular event that marks the mitochondria for destruction while simultaneously inhibiting mitochondrial ...example, ...
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S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease
... S-nitrosylated parkin by comparing results in cells with and without exogenously-expressed ...of parkin induces p53-mediated apoptosis in neuronal ...of parkin but also inhibits the ability of ...
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Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
... of Parkin may be proteasome-independent (reviewed in ...promoting cell death it can also act in a protective manner contributing to a quality control process that likely involves degradation by ...
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The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
... or parkin cause auto- somal-recessive and some sporadic forms of Parkinson’s ...disease. pink1 acts upstream of parkin in a common genetic pathway to regulate mitochondrial integrity in ...between ...
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Identification of deubiquitylases involved in parkin-mediated mitophagy
... of Parkin resulted in a small percentage of mitophagic cell death that was dependent on both PINK1 and ...This cell death was prevented or delayed by inhibiting the ...
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The Role of Parkin-Mediated Mitophagy in Cardiovascular Diseases
... programmed cell death ...model, Parkin protein expression is significantly increased after ischemic precondition, and then P62 is translocated to ...whose Parkin is knockout is sensitive to ...
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Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death via suppressing CaMKII/Parkin/mitophagy axis
... Discussion Based on our results, we confirmed that human cervi- cal cancer HeLa cell death was triggered by TNF-α via apoptosis. Interestingly, melatonin co-treatment could further amplify TNF-α-initiated ...
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Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53
... With respect to glucolipotoxicity-induced hepatocellular toxicity and the role of metformin in alleviating glucolipotoxicity, we observed a dose-dependent increase in p53 protein expression in HepG2 cells treated with ...
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Involvement of PINK1/parkin-mediated mitophagy in ZnO nanoparticle-induced toxicity in BV-2 cells
... microglia cell line, BV-2, pur- chased from the CBCAS (Cell Bank of the Chinese Academy of Sciences, Shanghai, People’s Republic of China), was maintained in Dulbecco’s Modified Eagle’s Medium containing ...
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Hexokinases link DJ-1 to the PINK1/parkin pathway
... Methods: A series of unbiased high-content screens were used to analyze changes at the protein, RNA, and metabolite level in rodent brains lacking DJ-1. Results were validated using targeted approaches, and cellular ...
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Pink1 and parkin demonstrate multifaceted roles when co expressed with Foxo
... promote cell survival or apoptosis, changes in Foxo activity may be the me- chanism behind the effects of Pink1 and parkin on the Foxo-induced ...of Pink1 or parkin may affect Foxo ...
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PINK1 Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium Induced Cell Death
... to PINK1 loss of function and have attempted to define mechanisms by which PINK1 deficiency renders neurons ...of PINK1 defi- ciency there is primarily an impairment of mitochondrial calcium efflux ...
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Ecdysone mediated programmed cell death in Drosophila
... regulating cell death in Drosophila ...starvation-induced cell death is accompanied by ...ecdysone- mediated PCD in Drosophila. Ecdysone- mediated PCD is vital for histolysis of ...
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PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses
... inappropriate PINK1-PARK2- mediated mitophagy appears to be mainly responsible for regulating cell fate, including PCD, cellular senescence, and myofibroblast differentiation during COPD and IPF ...
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Bcl 2 family proteins participate in mitochondrial quality control by regulating parkin/PINK1 dependent mitophagy
... with Parkin and to impede its stable recruit- ment to depolarized mitochondria, thereby raising the threshold for clearance of the latter via ...accelerating Parkin recruitment to impaired mitochondria, ...
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Drosophila PINK1 and parkin loss of function mutants display a range of non motor Parkinson’s disease phenotypes
... considering PINK1 and parkin are thought to act in the same ...in PINK1 null flies than in parkin null ...in parkin null flies are impaired only to the point of reducing their ongoing ...
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Parkin, PINK1, and DJ 1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
... in PARKIN, pten-induced putative kinase 1 (PINK1), and DJ-1 are individually linked to autosomal recessive early-onset familial forms of Parkinson disease ...that Parkin, PINK1, and DJ-1 ...
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Dapagliflozin rescues endoplasmic reticulum stress mediated cell death
... www.nature.com/scientificreports www.nature.com/scientificreports/ stress 38–40 . In this study, we demonstrated that dapagliflozin regulates ER stress by reducing glucose concentration as well as glucose influx into ...
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