PIPERAZIN-1-YL
methanone derivatives](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
Synthesis, Characterization and Crystal Structures of [4 substituted(aryl) piperazin 1 yl](thieno[2,3 c]pyridin 5 yl)methanone derivatives
... 4-(methoxyphenyl)- piperazin-1-yl](thieno[2,3-c]pyridin-5-yl)methanone (1), 4-(fluorophenyl)-piperazin-1-yl](thieno[2,3-c]pyridin-5- yl)methanone (2), ...
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Synthesis of novel (1 substituted benzenesulfonyl 1H indol 5 yl) (4 substituted piperazin 1 yl) methanone derivatives as 5 HT6R ligands
... (1H-Indol-5-yl)-(4-substituted piperazin-1-yl)-methanone derivatives, 6a and 6b were synthesized following the method given in Scheme - ...
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Synthesis, Antimicrobial activity of piperazin 1 yl (3,4,5 Trimethoxyphenyl)Methanone Derivatives
... Compound 1 (7 g, 0.01841 mol, 1.0 eq) was dissolved in dry dichloromethane (70 mL). The reaction mixture was cooled to 0 0 C and added slowly trifluoroacetic acid (6.3 g, 0.05523 mol, 3.0 eq). The reaction mixture ...
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Bis[4 (2 methyl 2 propenyl)piperazin 1 yl]methane
... and the solvent removed under reduced pressure. 1-(2-Methyl-2- propenyl)piperazine (1.3 g) was formed as a colourless oil in 75% yield. Bis[4-(2-methyl-2-propenyl)piperazin-1-yl]methane, (I), ...
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Crystal structure of 4 [4 (ethoxycarbonyl)piperazin 1 yl]benzoic acid
... A search of the Cambridge Structural Database (CSD, Version 5.37, update February 2015; Groom et al., 2016) revealed 11 crystal structures containing the (ethoxycarbon- yl)piperazin-1-yl ...
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1 [4 (4 Chlorophenyl)piperazin 1 yl] 3 (6 oxo 3,4 diphenyl 1,6 dihydropyridazin 1 yl)propan 1 one
... 1-[4-(4-Chlorophenyl)piperazin-1-yl]-3-(6-oxo-3,4-diphenyl-1,6-dihydropyridazin-1-yl)propan-1-one has analgesic and anti-inflammatory effect. Its in vivo analgesic and ...
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Evaluation of novel 1-(4-(substituted)piperazin-1-yl)-2-(phenylamino)ethanone derivatives as Falcipain-2 inhibitors
... 2-(phenylamino)- 1-(piperazin-1-yl) ethanone (5) was ...of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC·HCl) and 1-hydroxybenzotriazole (HOBt) under nitrogen ...
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2 {4 [(1,3 Benzodioxol 5 yl)methyl]piperazin 1 yl}pyrimidine
... The triethylamine catalyzed reaction of 5-chlorobenzo[d][1,3]dioxole (8.5 mmol) and 2-(piperazin-1-yl)pyrimidine (8.1 mmol) was carried out in isopropyl alcohol (10 mL). The reaction mixture was ...
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Synthesis and evaluation of antifungal activity of 5-chloro-1-methyl-2- -[(N4-aryl) piperazin-1-yl] ethyl benzimidazoles
... The availability over the past 2 decades of the azole antifungal agents represents a major advance in management of systemic fungal infections. Like miconazol, fluconazole itraconazlole. These drugs having some drawbacks ...
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SYNTHESIS, CHARACTERIZATION AND ANTIOXIDANT ACTIVITY OF NOVEL 9 (PIPERAZIN 1 YL) ACRIDINE DERIVATIVES
... A series of nitrogen-containing heterocyclic compounds such as substituted 9-(piperazin-1-yl) acridine derivatives were synthesized by [(4-Methyl-2-nitrophenyl) amino] benzoic acid, phosphorus ...
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1 [4 (4 Hydroxyphenyl)piperazin 1 yl]ethanone
... acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H- imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)- piperazine [(2R,4S)-(+)-ketoconazole] (Peeters et al., 2004), 1-{4-[bis ...
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Benzyl and Sulfonyl Derivatives of N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide(T2288): Biological Screening and Fingerprint Applications
... and completion of reaction was checked by TLC. Reaction mixture was poured into ice-cold water and extracted with methylene dichloride. The organic layers was washed with brine solution, dried over anhydrous sodium ...
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Synthesis and screening of some novel 1-((5-phenyl-1,3,4- oxadiazol-2-yl)methyl)-3-((piperazin-1-yl)methyl)-1Hindazole
... 2-(3-((piperazin- 1-yl) methyl)-1H-indazole-1-yl) acetohydrazide, with an appropriate aromatic carboxylic acid in presence of polyphosparic acid under reflux afforded the title ...
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catena Poly[[[(1 ethyl 6 fluoro 4 oxo 7 (piperazin 1 yl) 1,4 dihydroquinoline 3 carboxylato κ2O3,O4)copper(II)] μ 1 ethyl 6 fluoro 4 oxo 7 (piperazin 1 yl) 1,4 dihydroquinoline 3 carboxylato κ3N7′:O3,O4] tetrahydrate]
... 7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate (norf) monoanions and a symmetry-generated N-bonded norf anion, resulting in a distorted square-pyramidal coordination environment with the N ...
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3 (Adamantan 1 yl) 4 ethyl 1 {[4 (2 methoxyphenyl)piperazin 1 yl]methyl} 1H 1,2,4 triazole 5(4H) thione
... 1991), 1-(2- methoxyphenyl)piperazine (383 mg, 2 mmol) and 37% formaldehyde solution (1 ml) in ethanol (8 ml) was heated under reflux for 15 min until a clear solution was ...
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3 (Adamantan 1 yl) 4 methyl 1 ({4 [3 (trifluoromethyl)phenyl]piperazin 1 yl}methyl) 4,5 dihydro 1H 1,2,4 triazole 5 thione
... Two independent molecules comprise the crystallographic asymmetric unit of (I), Fig. 1. The molecules are related across a pseudo centre of inversion. As shown in Fig. 2, the best fit between the molecules occurs ...
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Crystal structure of 3 {[4 (2 methoxyphenyl)piperazin 1 yl]methyl} 5 (thiophen 2 yl) 1,3,4 oxadiazole 2(3H) thione
... pharmacophore of several biologically active agents. It is composed of a methyl(thiophen-2-yl)-1,3,4-oxadiazole-2(3H)-thione moiety linked to a 2-methoxyphenyl unit via a piperazine ring that has a chair ...
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(E) 1 {4 [Bis(4 bromophenyl)methyl]piperazin 1 yl} 3 (4 ethoxy 3 methoxyphenyl)prop 2 en 1 one
... The synthesis follows the method of Wu et al. (2008). The title compound was prepared by stirring a mixture of (E)-3-(4- ethoxy-3-metoxyphenyl)acrylic acid (0.889 g; 4 mmol), dimethyl sulfoxide (2 ml) and dichloromethane ...
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2 {2 [4 (4 Fluorophenyl)piperazin 1 yl] 2 oxoethyl} 6 (morpholin 4 yl) 4 phenylpyridazin 3(2H) one
... (N1/N2/C7–C10) makes dihedral angles of 28.03 (7) and 77.46 (7) ° with the C1–C6 phenyl and C21–C26 benzene rings, respectively. The phenyl and benzene rings make a dihedral angle of 50.17 (8) ° with each other. In the ...
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(E) 1 {4 [Bis(4 methoxyphenyl)methyl]piperazin 1 yl} 3 (4 fluorophenyl)prop 2 en 1 one
... The synthesis follows the method of Wu et al. (2008). A mixture of (E)-3-(4-fluoro phenyl)acrylic acid (1.66 g; 10 mmol), dimethyl sulfoxide (4 ml) and dichloromethane (60 ml) was stirred for 6 h at room temperature. The ...
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