Piperazine derivative
PIPERAZINE DERIVATIVES: A POTENTIALLY TOOL FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
... The aim of this review is to compile information about the reported neurobiological effects of piperazine derivatives. Piperazine derivatives are molecules with a wide variety of neurological activity. ...
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COMPARISON OF ANTIHELMINTHIC ACTIVITY BETWEEN BISARYL BENZYL PIPERAZINE AND BENZIMIDAZOLE LINKED PIPERAZINE DERIVATIVES
... DISCUSSION: Various piperazine derivatives were prepared by two different schemes viz. scheme 1 and scheme 2. In scheme 1, ethylene diamine was reacted with substituted benzaldehyde in presence of ammonium ...
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SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 1 BENZ HYDRYL PIPERAZINE DERIVATIVES
... with piperazine framework, several 1-benzhydryl piperazine derivatives and 1- benzhydryl piperazine acyl derivatives were ...1-benzhydryl piperazine with various acyl ...and piperazine ...
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SYNTHESIS OF NEW (2,4-DIOXOTHIAZOLIDIN-5-YL)ACETIC ACID DERIVATIVES WITH PIPERAZINE AND 1,2,4-TRIAZOLE SUBSTITUTES AND THEIR ANTIMICROBIAL ACTIVITY EVALUATION
... and piperazine that have been a various pharmacological ...Besides, piperazine derivatives also have a wide Corresponding Author: - Nazar Trotsko Email: ...
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Piperazine and morpholine: Synthetic preview and pharmaceutical applications
... of piperazine derivatives have synthesized by Baliet al, 36 and evaluated for a typical antipsychotic activity in apomorphine induced mesh climbing and stereotypy assays in ...
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Synthesis, Biological evaluation and Comparative Study of Some Cinnoline Derivatives
... cinnoline piperazine derivatives (11a-j), cinnoline thiophene derivatives (12a-j) cinnoline furan derivatives (13a-j) cinnoline pyrazole derivatives (14a-j) and cinnoline imidazole derivatives (15a-j) were ...
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PIPERAZINE – A BIOLOGICALLY ACTIVE SCAFFOLD
... of piperazine derivatives as anticonvulsants. The activity of piperazine as antihistaminic and their potent anthelmintic activity are ...The piperazine derivatives have demonstrated significant ...
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3 [4 (2 Chlorophenyl)piperazinomethyl] 5 methyl 1 benzoxazolin 2(3H) one
... 5-Methyl-2-benzoxazolinone was prepared by a modi®cation of the procedure described by Bywater et al. (1945), using 0.1 mol 4-methyl- 2-aminophenol and 0.12 mol urea. The mixture was fused at 418± 423 K for 4 h in a ...
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Synthesis and Biological Activity of Triazole Analogues of Piperazine
... 4. J. P. Yevich, J. S. New, D. W. Smith, W. G. Lobeck, J. D. Catt, J. L. Minielli, M. S. Eison, D. P. Taylor, L. A. Riblet, D. L. Temple, “Synthesis and biological evaluation of 1-(1,2- benzisothiazol-3-yl)- and ...
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B. Vijayakumar, P. Dheen Kumar, D. Babuananth, R. Murugan, P. Gobalakrishnan, M. Nishanthi
... containing piperazine rings are associated with a wide range of biological properties such as antimicrobial, anticancer, antihypertensive, analgesic, antidepressant, anti- inflammatory and antiheliminthic ...
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EXPLORING PHARMACOLOGICAL SIGNIFICANCE OF PIPERAZINE SCAFFOLD
... Hence there is a outmost need to investigate and design new compounds of biological interest. As per the review about the recent trends in the chemistry of piperazine derivatives, their demand in pharmaceuticals ...
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N,N′ Bis(4 pyridylformyl)piperazine
... The title molecule has a crystallographically imposed centre of symmetry. All bond lengths and angles have normal values (Allen et al., 1987). In contrast to the planar conformation of piperazinedione (Wen et al., 2004), ...
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1 [Bis(4 fluorophenyl)methyl]piperazine
... Piperazine is currently the most important building block used in drug discovery with a high number of positive hits encountered in biological screens of this heterocycle and its congeners. They are found in ...
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1 Benzyl 4 (4 tert butylphenyl)piperazine
... Data collection: SMART Bruker, 2000; cell refinement: SAINTPlus Bruker, 2000; data reduction: SAINT-Plus; programs used to solve structure: SHELXTL Bruker, 2000; programs used to refine [r] ...
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1 Benzhydryl 4 (4 chlorophenylsulfonyl)piperazine
... the piperazine ring are best described by the torsion angle values of ...the piperazine ring and thus are in the equatorial plane of the piperazine ...
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TREATMENT OF ASCARIASIS IN CHILDREN WITH A SINGLE DOSE OF PIPERAZINE CITRATE
... The infections in the hospitalized patients usually were completely eliminated within 1 to 4 days after the single dose of piperazine citrate. Observation of the hos- pitalized patients [r] ...
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2,5 Dinitro 7,9 dioxa 2,5 diazabicyclo[4 3 0]nonan 8 one
... the piperazine ring, which is disordered over two conformations with occupancies of ...the piperazine ring are affected by the nitration of the N atoms, and the disorder of the ethylene backbone, and the ...
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Diagnosis and control of anthelmintic resistant Parascaris equorum
... resistance, piperazine or anthelmintics of the benzimidazole or pyrimidine classes can be used to control ascarid infections, but Parascaris populations that are concurrently resistant to macrocyclic lactones and ...
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1,4 Bis(4 methoxyphenyl)piperazine 2,5 dione
... re®ned isotropically [CÐH = 0.946 18±1.04 2 A Data collection: SMART Siemens, 1996; cell re®nement: SAINT Siemens, 1996; data reduction: SAINT; programs used to solve structure: SHELXTL [r] ...
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catena Poly[[silver μ piperazine κ2N:N′] perchlorate]
... with piperazine rules out direct interaction between the metal ion and the ligand in acetonitrile (Grzejdziak, ...the piperazine adduct is a normal coordination bond, as found in the present study (Scheme ...
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