Piperazine derivatives
COMPARISON OF ANTIHELMINTHIC ACTIVITY BETWEEN BISARYL BENZYL PIPERAZINE AND BENZIMIDAZOLE LINKED PIPERAZINE DERIVATIVES
... benzimidazole derivatives, so as medicinal chemist the attention will be drawn towards these different moieties which exert same biological action, in this present work five derivatives of piperazine ...
9
Structural and quantum chemical studies on aryl sulfonyl piperazine derivatives
... occupied Lewis-type (donor) NBOs to properly unoccupied non-Lewis type (acceptor) NBOs within the molecule. The stabilization of orbital interaction is proportional to the energy difference between interacting orbitals. ...
10
Synthesis of pyrimidine incorporated piperazine derivatives and their antimicrobial activity
... The standard drugs chloramphenicol and fluconazole have structural analogues of synthesized piperazine derivatives. Due to the presence of electronegativity functionality such as nitrogen, oxygen and ...
7
A valuable insight into recent advances on antimicrobial activity of piperazine derivatives
... them piperazine derivatives have shown a broad spectrum of pharmacological activities like antibacterial, antifungal, antitubercular, anticancer, antiviral, antioxidant activities ...different ...
19
Synthesis and Biological Evaluation of Some Piperazine Derivatives as Anti-Inflammatory Agents
... In conclusion, we reported here a series of 1,4-disubstituted piperazine derivatives as anti-inflammatory agents. Synthesized compounds (42-c, 42-d &42-h) exhibit good anti-inflammatory activity but two ...
6
PIPERAZINE DERIVATIVES: A POTENTIALLY TOOL FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
... N. Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5- HT 1A receptors negatively coupled with adenylate cyclase in hippocampal ...
5
SYNTHESIS AND EVALUATION OF MANNICH BASES OF SUBSTITUTED PIPERAZINE DERIVATIVES AS ANTICONVULSIVE AGENTS
... substituted piperazine derivatives (1a-1f) were synthesized via feasible mannich ...the derivatives, compound 1e displayed significant protection against PTZ induced seizures where as other ...
5
Corrosion Inhibition of Steel in Hydrochloric Acid Solution by New N,N’-Bipyrazole Piperazine Derivatives
... N,N’-bipyrazole piperazine derivatives namely piperazine (P1), N,N’-bis[(3,5-dimethyl-1H-pyrazol-1- yl)methyl]piperazine (P2) and N,N’-bis[(3-ethylcarboxylate-5-methyl-1H-pyrazol-1-yl)methyl] ...
18
Fire Self Extinguishing Cotton Fabric: Development of Piperazine Derivatives Containing Phosphorous Sulfur Nitrogen and Their Flame Retardant and Thermal Behaviors
... of Piperazine derivatives containing phospho- ...tetraethyl piperazine-1,4-diyldiphosphonate (TEPP) and phosphorus-nitrogen sulfur base O,O,O’,O’-tetramethyl ...
15
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 1 BENZ HYDRYL PIPERAZINE DERIVATIVES
... with piperazine framework, several 1-benzhydryl piperazine derivatives and 1- benzhydryl piperazine acyl derivatives were ...1-benzhydryl piperazine with various acyl ...and ...
5
SYNTHESIS OF BENZIMIDAZOLONE-BENZTHIAZOLE AND ITS PIPERAZINE DERIVATIVES WITH PHARMACOLOGICAL ACTIVITY
... Benzothiazole derivatives have its own biological activity such antimicrobial ,antiviral, anticancer antiulcer antifungal ...–Benzothiazole derivatives were synthesized and checked its biological ...
10
Synthesis and antimicrobial activity of novel series of benzoxazinone containing piperazine derivatives
... The present work is concerned with the synthesis of some new compounds comprising different benzoxazinones 4-(3-(dimethylamino-propyl)-4H-benzo[b][1,4]oxazin-3-one containing secondary amines derivatives.. Their ...
8
Synthesis and Biological Activity of Triazole Analogues of Piperazine
... 4. J. P. Yevich, J. S. New, D. W. Smith, W. G. Lobeck, J. D. Catt, J. L. Minielli, M. S. Eison, D. P. Taylor, L. A. Riblet, D. L. Temple, “Synthesis and biological evaluation of 1-(1,2- benzisothiazol-3-yl)- and ...
9
Piperazine and morpholine: Synthetic preview and pharmaceutical applications
... The piperazine template contains some building features and pharmacological points that provides potent and selective ligands for a range of different biological targets in medicinal ...15 Piperazine ...
21
EXPLORING PHARMACOLOGICAL SIGNIFICANCE OF PIPERAZINE SCAFFOLD
... of piperazine derivatives, their demand in pharmaceuticals is increasing and much still lies scope for the exploration of pharamaco-kinetics of these ...
12
ACID AMINE COUPLING OF (1H INDOLE 6 YL)PPIPERAZIN 1 YL)METHANONE WITH SUBSTITUTED ACIDS USING HATU COUPLING REAGENT AND THEIR ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY
... their derivatives play an important role in biological and medicinal ...Indole piperazine derivatives 13-15 was compared to well known antioxidants Trolox and ...
7
SYNTHESIS OF NEW (2,4-DIOXOTHIAZOLIDIN-5-YL)ACETIC ACID DERIVATIVES WITH PIPERAZINE AND 1,2,4-TRIAZOLE SUBSTITUTES AND THEIR ANTIMICROBIAL ACTIVITY EVALUATION
... and piperazine derivatives (8, 9) a series of novel corresponding N ’ -substituted-(2,4-dioxothiazolidin-5- yl)acetohydrazides (10-13), ...
7
PIPERAZINE – A BIOLOGICALLY ACTIVE SCAFFOLD
... of piperazine has established it as one of the biologically important ...the piperazine in the present context and promise they hold for the ...active piperazine derivatives that have been ...
14
Design, Synthesis, Characterization and Biological Evaluation of Various N- substituted Piperazine Annulated s-Triazine Derivatives
... diphenyl piperazine derivatives possess broad pharmacological action on central nervous system (CNS), especially on dopaminergic neurotransmission 19 ...N-substituted piperazine derivatives to ...
6
SYNTHESIS AND ANTIMICROBEAL ACTIVITY OF SULFONYL AND CARBOXAMIDE DERIVATIVES OF CYCLOPROPYL PIPERAZINE
... methanone derivatives refers that these compounds possess anticancer and anti-tuberculosis ...[6,7] Piperazine derivatives play a significant role in metabolism and are considered relatively ...
11