PLA2-I
Differential expression of Lp PLA2 in obesity, type 2 diabetes and the influence of lipids
... adiposity in omental adipose tissue [29, 30]. Therefore, it was important to ascertain the contribution of macrophages to Lp- PLA2 in adipose tissue, as well as to explore the potential cellular site of ...
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Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease
... We have quantified the percentages of astrocytes that were immunoreactive for sPLA 2 -IIA and GFAP, and also the percentages of sPLA 2 -IIA-positive astrocytes that are asso- ciated with[r] ...
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Research on the Clinical Phenotype of Coronary Heart Disease with Retinol Binding Protein 4, Lipoprotein-related Phospholipase A2, and the Severity of Coronary Artery Lesion
... Coronary heart disease is one of the common diseases in cardiology. Many risk factors and chronic inflammatory reaction can lead to the formation of coronary heart disease. One of the common risk factors is dyslipidemia. ...
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Evaluation of lipoprotein-associated Phospholipase A2 in Healthy Chinese Han Adult Serum
... Lp- PLA2 changes with adolescent obesity ...apoA I, which was confirmed by the results of this ...Lp- PLA2 is present in atherogenic ...Lp- PLA2 was positively associated with the variations ...
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Original Article Clinical significance of lipoprotein associated phospholipase A2 and uric acid in patients with acute coronary syndrome
... Despite existing widely accepted biomarkers such as CK-MB, CRP, TnI, and NT-proBNP, new biomarkers are still needed to give more accu- rate clinical diagnosis, as well as providing deeper understanding for the pathology ...
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Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment
... multiple PLA2 isoforms classified as secreted (sPLA2) and cytosolic (cPLA2) that have different structures and various physiological ...lipoprotein-associated PLA2 (Lp-PLA2) or sPLA2-X or sPLA2-V ...
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Effect of percutaneous nucleoplasty with coblation on phospholipase A2 activity in the intervertebral disks of an animal model of intervertebral disk degeneration: a randomized controlled trial
... the PLA2 activity in the intervertebral disk, resulting in pain relief in the treatment of low back pain, although the exact mechan- ism remains ...of PLA2. As a re- sult, the PLA2 activity decreased ...
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The potent anti Staphylococcus aureus activity of a sterile rabbit inflammatory fluid is due to a 14 kD phospholipase A2
... II PLA2 after cell activation (29, 41–45), the cellular origin of extracellular PLA2 during (local) inflammation is ...no PLA2 or anti- staphylococcal activity suggesting that PLA2 is ...
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Plasma lipoprotein associated phospholipase A2 and superoxide dismutase are independent predicators of cognitive impairment in cerebral small vessel disease patients: diagnosis and assessment
... BM I, cholesterol, HDL-C, LDL-C, urea, Cr, UA, hypertension, diabetes, CHD, APOE genotype, and medication use) followed by a post hoc Bonferroni ...- PLA2 and SOD than the normal cognition (NC) group (see ...
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In silico and in vitro study of the bromelain-phytochemical complex inhibition of phospholipase A2 (Pla2)
... Abstract: Phospholipase A2 (Pla2) is an enzyme that induces inflammation, making Pla2 activity an effective approach to reduce inflammation. Therefore, investigating natural compounds for this Pla2 ...
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Effect of Platelet Glycoprotein IIb/IIIa PLA2 Polymorphism on Severity of Pulmonary Thromboembolism
... Our data suggest that presence of PLA2 is associated with an increased risk of PTE in the Iranian population. The association between recurrent events and coinheritance of more than one thrombophilic genetic risk ...
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Lp-Pla2 Selective Inhibitor (Darapladib) Effect in Lowering Insulin Resistance and Aortic tissue Inflammation at type 2 Diabetes Mellitus
... Lp-PLA2 appeared as an effective marker in detecting cardiovascular disease. Macrophages that infiltrate adipose tissue increase the production of Lp-PLA2.Lp-PLA2 induces the expression of several ...
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Synergistic effects of colchicine combined with atorvastatin in rats with hyperlipidemia
... Lp- PLA2 excretion by macrophages and foam cells ...Lp- PLA2 production was dependent on its effects on amelior- ating inflammation and improving endothelial ...
6
Original Article Association of Lp-PLA2 mass and heart failure in a cohort of Nantong population
... Abstract: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a useful inflammatory marker which correlated with the development of coronary artery disease (CAD). Inflammatory cytokines may be involved in the ...
9
Glucocorticoid deficiency increases phospholipase A2 activity in rats
... total PLA2 activity was higher than that of mRNA or PLA2 protein, suggesting that the activity of the enzyme was modulated by inhibitors or ...of PLA2 enzyme was strongly correlated with the activity ...
8
Increased Lipoprotein-associated phospholipase A2 activity portends an increased risk of resistant hypertension
... Lp- PLA2 activity, patients with high Lp-PLA2 activity had higher office SBP and DBP, and 24 h mean SBP and DBP, and the incidence of RH was also significantly higher in high Lp-PLA2 activity group ...
5
Production of long-chain free fatty acids from metabolically engineered Rhodobacter sphaeroides heterologously producing periplasmic phospholipase A2 in dodecane-overlaid two-phase culture
... Results: The recombinant R. sphaeroides strain Rs‑A2, which heterologously produces Arabidopsis thaliana phospho‑ lipase A2 (PLA2) in the periplasm, excretes FFAs during growth. FFA productivity under ...
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Liver cirrhosis induces renal and liver phospholipase A2 activity in rats
... (100 8 C) before being resolved by 12.5 or 8.0% SDS–polyacrylamide gel electrophoresis (34). The proteins were transferred to PVDF Im- mobilon membrane (Millipore AG, Volketswil, Switzerland) by elec- troblot using ...
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Cell wall determinants of the bactericidal action of group IIA phospholipase A2 against Gram positive bacteria
... aureus are equally susceptible to phospholipid degradation by PLA2, differences in their autolytic activity 9 apparently do not affect the access of PLA2 to the bacterial membrane.. The [r] ...
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Cell specific regulation of type II phospholipase A2 expression in rat mesangial cells
... proinflammatory mediators, implicated in the pathogenesis of glomerulonephritis, and have assessed whether the activation of second messenger systems modulates or mimics PLA2 gene expression by cytokines. IL-1 ...
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