Planar cell polarity (PCP)
Planar cell polarity in moving cells: think globally, act locally
... the planar cell polarity (PCP) pathway, the fundamental function of which is the communication of polarity information between adjacent cells in the plane of a tissue, with outcomes are that ...
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Planar cell polarity genes control the connectivity of enteric neurons
... the planar cell polarity (PCP) genes Celsr3 and Fzd3 are required during murine embryogenesis to specifically control the guidance and growth of enteric neuronal projections relative to the ...
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Novel Regulators of Planar Cell Polarity: A Genetic Analysis in Drosophila
... ABSTRACT Planar cell polarity (PCP) is a common feature of many epithelia and epithelial ...for cell polarity in nonciliated ...
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A novel function for the Rab5 effector Rabenosyn 5 in planar cell polarity
... apicobasal polarity, perpendicular to the plane of the ...of polarity called planar cell polarity ...epithelial polarity in vivo (Adler, 2002; Eaton, ...Each cell of the ...
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Gpr125 modulates Dishevelled distribution and planar cell polarity signaling
... Wnt/planar cell polarity (PCP) signaling orchestrates polarized cell behaviors underlying convergence and extension (C&E) movements to narrow embryonic tissues mediolaterally and lengthen ...
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Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous
... normal planar cell polarity (PCP) of several Drosophila tissues, including the orientation of hairs of the wing and abdomen and of larval denticles, and the orientation of fate choices in developing ...
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Twinstar, the Drosophila homolog of cofilin/ADF, is required for planar cell polarity patterning
... of planar cell polarity (PCP), in which cells adopt a uniform orientation within the plane of an epithelium (Adler, 2002; Gubb and Garcia-Bellido, 1982; Uemura and Shimada, ...
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The planar cell polarity protein Vangl2 bidirectionally regulates dendritic branching in cultured hippocampal neurons
... Planar cell polarity has been highly scrutinized in Dros- ophila. In recent years, evidence has accumulated sug- gesting that the PCP pathway is highly conserved and regulates polarized cellular and ...
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Is a Persistent Global Bias Necessary for the Establishment of Planar Cell Polarity?
... Planar cell polarity (PCP)–the coordinated polarisation of a whole field of cells within the plane of a tissue–relies on the interaction of three modules: a global module that couples individual ...
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Prickle/spiny legs isoforms control the polarity of the apical microtubule network in planar cell polarity
... MT polarity is poorly ...for planar polarization is derived from the alignment of a parallel apical network of MTs and the directional MT-dependent trafficking of downstream signaling ...’ planar ...
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Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120 catenin
... of cell-cell contacts whereas the execution of hair cell planar cell polarity is regulated via a Pcdh15-dependent ...of cell-cell contacts is not ...interpret ...
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Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity
... common planar cell polarity (PCP), as exemplified by the consistent orientation of hairs on mammalian skin and insect ...one cell and Stan acting together with Fz in its neighbour: such ...
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Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo
... The stronger phenotypes of the Vangl1 Vangl2 double mutants and the Dvl1/Dvl2/Dvl3 compound mutants compared with single PCP mutants provide a tool to identify other proteins required for planar cell ...
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Regulation of long range planar cell polarity by Fat Dachsous signaling
... called planar cell polarity ...altered polarity (Casal et ...of polarity in wild-type tissue, called domineering non-autonomy (Krasnow et ...many cell lengths, indicating that ...
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Roles of planar cell polarity pathways in the development of neutral tube defects
... epithelial planar cell polarity and dendritic field deploy- ment ...a planar cell polarity pathway in vertebrate neurulation ...
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Airway epithelial homeostasis and planar cell polarity signaling depend on multiciliated cell differentiation
... the planar cell polarity (PCP) signaling pathway ...directional cell behaviors, including cell migration, oriented cell division, and polarized cell morphologies ...via ...
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The cadherin Fat2 is required for planar cell polarity in the Drosophila ovary
... Planar cell polarity is an important characteristic of many ...of planar cell polarity requires the core planar cell polarity genes and two cadherins, Fat ...
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Coupling of apical basal polarity and planar cell polarity to interpret the Wnt signaling gradient in feather development
... orient cell growth is crucial in tissue ...core planar cell polarity gene Prickle1 is involved, as knockdown of its expression resulted in no cell shape change and no barb ...
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Spalt transcription factors are required for R3/R4 specification and establishment of planar cell polarity in the Drosophila eye
... eye requires correct specification of the R3/R4 pair of photoreceptor cells. In response to a polarizing factor, Frizzled signaling specifies R3 and induces Delta, which activates Notch in the neighboring cell, ...
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Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea
... sensitive to generalized cellular abnormalities, making it difficult in some circumstances to directly link a mutation to PCP-specific deficits. To better understand this, we analyzed polarity defects within the ...
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