Plasmacytoid dendritic cell
Case Report CD31 is a surrogate marker for blastic plasmacytoid dendritic cell neoplasm: a case of a hematologic skin tumor immunohistochemically false negative for CD45
... Round cell tumors of the skin in the adult constitute one of the diagnostic challenges for histopathologists, because their differential diagnosis covers a broad spectrum of tumors of epithelial as well as ...
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Blastic plasmacytoid dendritic cell neoplasm: challenges and future prospects
... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and clinically aggres- sive CD4 + CD56 + hematopoietic malignancy with no lineage-specific markers that has no defined standard of ...
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Case Report Sustained complete remission of a limited-stage blastic plasmacytoid dendritic cell neoplasm followed by a simultaneous combination of low-dose DeVIC therapy and radiation therapy: a case report and review of the literature
... examination, etc., were performed, but no lesions were detected at other sites. Based on the above findings a diagnosis of blastic plasmacytoid dendritic cell neoplasm (BPDCN), Stage IEA, was made. ...
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Exploring the effect of chidamide on blastic plasmacytoid dendritic cell neoplasm: a case report and literature review
... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematopoietic malignancy mainly affecting elderly ...stem cell transplantation; thus, the discovery of novel ...
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Case Report Lymph blastic plasmacytoid dendritic cell neoplasm: a case report and review of literature
... Beijing Friendship Hospital, Capital Medical University revealed that CD4 and CD99 were positive within the lymph follicle region. In addi- tion, CD43, CD123 and TDT were positive, whereas CD117, MPO, CD8 and CD10 were ...
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<p>Tagraxofusp for the Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN): A Brief Report on Emerging Data</p>
... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malig- nancy, for which conventional chemotherapy has poor ...blastic plasmacytoid dendritic cell neoplasm, ...
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Case Report A case of blastic plasmacytoid dendritic cell neoplasm with ecchymotic lesions on the whole body
... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) derived from plasmacytoid dendritic cell precursors is a very rare, and characterized by cutaneous and bone marrow ...
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Classification and clinical behavior of blastic plasmacytoid dendritic cell neoplasms according to their maturation- associated immunophenotypic profile
... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a relatively rare subtype of leukemia/ lymphoma - < 1% of hematologic malignancies [1]- which has been recently categorized in the 2008 ...
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<p>Case Report of Anti-CD123 Chimeric Antigen Receptor T-Cell Therapy Followed by Radiotherapy for a Recurrence of Blastic Plasmacytoid Dendritic Cell Neoplasm After Allogeneic Hematopoietic Stem Cell Transplantation</p>
... In January 2018, a 10-year-old male patient had been experiencing bilateral knee joint pain for fi ve months. The patient received a bone marrow (BM) smear and BM biopsy when he presented with anemia. Flow cytome- try ...
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Characterization of the Plasmacytoid Dendritic Cell Response to Transmitted/Founder and Nontransmitted Variants of HIV-1
... The plasmacytoid dendritic cell (pDC) is the first cell type recruited to the site of HIV-1 exposure; however, its contribution to the viral bottleneck in HIV-1 transmission has not been ...
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Plasmacytoid Dendritic Cell Dynamics and Alpha Interferon Production during Simian Immunodeficiency Virus Infection with a Nonpathogenic Outcome
... Flow cytometry. Flow cytometric analyses were performed on freshly isolated cells. CD4 ⫹ T cells were quantitated as previously described (26). For PDC quantification, cells were stained with the following monoclonal ...
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HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent Mechanisms
... T cell homeostasis and fast progression to ...T cell depletion within a human fetal thymic organ culture (H-FTOC) ...enhanced cell-to-cell spread of the virus ...
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TRAIL-mediated killing of acute lymphoblastic leukemia by plasmacytoid dendritic cell-activated natural killer cells
... stem cell transplantation (HSCT), underscoring the need to improve the graft-versus- leukemia (GvL) ...NK cell-mediated ...NK cell stimulation with TLR-9-activated plasmacytoid ...
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Plasmacytoid Dendritic Cell Infection and Sensing Capacity during Pathogenic and Nonpathogenic Simian Immunodeficiency Virus Infection
... immune cell subsets to resist infection might contribute to the asymptomatic nature of simian immu- nodeficiency virus (SIV) infection in its natural hosts, such as African green monkeys (AGM) and sooty mangabeys ...
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Peripheral Blood CD4 T-Cell and Plasmacytoid Dendritic Cell (pDC) Reactivity to Herpes Simplex Virus 2 and pDC Number Do Not Correlate with the Clinical or Virologic Severity of Recurrent Genital Herpes
... An additional CD4 T-cell specimen set was obtained from persons who donated serial blood specimens after a documented HSV-2 genital recurrence. These individuals had blood obtained during the recurrence, at which ...
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Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies
... Blastic plasmacytoid dendritic cell neoplasm; BV: Brentuximab vedotin; CAR: Chimeric antigen receptor; cCAR: Compound CAR; CIK: Cytokine-induced killer; CLL: Chronic lymphocytic leukemia; CML: ...
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New application of anti-TLR monoclonal antibodies: detection, inhibition and protection
... conventional dendritic cell; BM-MC: bone marrow-derived macrophage; BM-pDC: bone marrow-derived plasmacytoid dendritic cell; CCR2: C-C chemokine receptor type 2; D34A mutation: alanine ...
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Early detection of transformation to BPDCN in a patient with MDS
... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy that was first described in 1995 and manifests mainly as cutane- ous lesions with or without lymph ...
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Plasmacytoid dendritic cells promote HIV 1–induced group 3 innate lymphoid cell depletion
... via plasmacytoid dendritic cells (pDCs) and a type I IFN–dependent (IFN-I–dependent) mecha- nism and sensitized them to undergo CD95/FasL-mediated ...
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Plasmacytoid Dendritic Cells Reduce HIV Production in Elite Controllers
... T cell apop- tosis. Indeed, when p24 ⫹ T cell levels in the coculture were ana- lyzed, we observed a reduction of p24 ⫹ T cell ...T cell-induced apoptosis, which is preserved in ...T ...
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