Plasmacytoid dendritic cells
Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation
... and plasmacytoid dendritic cells (mDCs, pDC) are crucial to the immune system, detecting microorganisms and linking the innate and adaptive ...
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Plasmacytoid Dendritic Cells Reduce HIV Production in Elite Controllers
... acterized. Plasmacytoid dendritic cells (pDCs) are innate immune cells that respond to viral infections, producing up to 1,000-fold more alpha interferon (IFN-␣) than other cell types (31) ...
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High Secretion of Interferons by Human Plasmacytoid Dendritic Cells upon Recognition of Middle East Respiratory Syndrome Coronavirus
... epithelial cells (18, 22). Additionally, professional antigen- presenting cells (APCs) are an important source of type I IFNs upon recognition of pathogen-associated molecular patterns (PAMPs) ...
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Characterization of Virus-Responsive Plasmacytoid Dendritic Cells in the Rhesus Macaque
... Plasmacytoid dendritic cells (PDC) are potent producers of alpha interferon (IFN- ␣ ) in response to enveloped viruses and provide a critical link between the innate and adaptive immune ...
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Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor
... by plasmacytoid dendritic cells (pDCs) in response to ICs consisting of autoantibodies and apoptotic or necrotic cell-derived nucleic acids ...B cells (NFκB) or IFN regulatory factor (IRF) 5 ...
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Plasmacytoid dendritic cells lead the charge against tumors
... Imiquimod is a TLR agonist that is used as an antitumor agent, mainly against skin tumors. Its clinical benefits are well described in several studies; however, the mechanisms behind its antitumor effects are not ...
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Efficient Virus Assembly, but Not Infectivity, Determines the Magnitude of Hepatitis C Virus-Induced Interferon Alpha Responses of Plasmacytoid Dendritic Cells
... primary plasmacytoid dendritic cells (pDC) with crude preparations of different cell culture-derived geno- type 2a HCV ...hepatoma cells retrieved the capacity to induce IFN-␣, whereas ...
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Increased Activity of NK Cells and Plasmacytoid Dendritic Cells in HIV Exposed Seronegative (ESN) Individuals
... of plasmacytoid dendritic cells (pDC) and in- creased production of IFN-α in response to viral infection have earlier been reported in the blood of long-term non- progressors and long-term survivors ...
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Plasmacytoid Dendritic Cells: Linking Innate and Adaptive Immunity
... Plasmacytoid dendritic cells (pDCs) are one of two principal subsets of human dendritic cells ...T cells,” or “plasmacytoid monocytes” (reviewed in reference ...these ...
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Characterization of Plasmacytoid Dendritic Cells in Bone Marrow of Pig-Tailed Macaques
... Plasmacytoid dendritic cells (pDCs), one of two types of bone marrow (BM)-derived blood DCs, play an important role in linking innate and adaptive immune ...these cells could initiate immune ...
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Differential Responses of Plasmacytoid Dendritic Cells to Influenza Virus and Distinct Viral Pathogens
... Plasmacytoid dendritic cells (pDCs) are key components of the innate immune response that are capable of synthesizing and rapidly releasing vast amounts of type I interferons (IFNs), particularly ...
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Hepatitis C Virus Fails To Activate NF-κB Signaling in Plasmacytoid Dendritic Cells
... Plasmacytoid dendritic cells (pDCs) respond to viral infection by production of alpha interferon (IFN-␣), proinflammatory cy- tokines, and cell ...hepatoma cells, in contrast to cell-free HCV ...
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Activation of Plasmacytoid Dendritic Cells by Kaposi's Sarcoma-Associated Herpesvirus
... infection. Plasmacytoid dendritic cells have been shown to be the major producers of type 1 IFN in response to stimuli in the blood cell population, indicating that they play a vital role in the host ...
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Human Plasmacytoid Dendritic Cells Elicited Different Responses after Infection with Pathogenic and Nonpathogenic Junin Virus Strains
... IFN-I levels in cell supernatants were studied with a stably transfected WISH cell line with the enhanced green fluorescent protein gene under the control of the IFN-I-inducible Mx2 promoter (23). The percentage of ...
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Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus
... of plasmacytoid DCs (pDCs) in this condition ...these cells have been shown to polarize T cells through its high production of IFN-α [2] , which is generally considered to be the central cytokine ...
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Human Plasmacytoid Dendritic Cells Sense Lymphocytic Choriomeningitis Virus-Infected Cells In Vitro
... LCMV-infected cells was also related to the exosome-mediated mechanism by which they respond to HCV-infected cells (8, ...Huh-7.5.1c2 cells was inhibited by the TLR7-specific antag- onist IRS661 ...
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Targeting Toll like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus
... apoptotic cells in lupus are somehow enriched in self-TLR9-binding DNA sequences, possibly related to decreased DNA methyltransferase activity [89] secondary to cellular activation ...TLR9-deficient cells ...
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Prognostic impact of high levels of circulating plasmacytoid dendritic cells in breast cancer
... Prognostic relevance of DCs together with MDSCs, regulatory T‑cells and CD8 + T‑cell responses to Her‑2 Because pDCs emerged in this analysis as having a sig- nificant impact on survival, we next analyzed associa- ...
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Distinct Intracellular Trafficking of Hepatitis C Virus in Myeloid and Plasmacytoid Dendritic Cells
... antigen-presenting cells host the processing and assembly reactions that result in the display of peptides on MHC class II ...T cells by delivery of ...
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Human Metapneumovirus M2-2 Protein Acts as a Negative Regulator of Alpha Interferon Production by Plasmacytoid Dendritic Cells
... cytoid dendritic cells ...HEK293T cells by transfection with myeloid dif- ferentiation factor 88 (MyD88), tumor necrosis factor receptor-associated factor 6 (TRAF6), IKK ␣ , and IFN regulatory factor ...
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