Plasminogen activator inhibitor-2
Interaction between plasminogen activator inhibitor type 1 (PAI 1) bound to fibrin and either tissue type plasminogen activator (t PA) or urokinase type plasminogen activator (u PA) Binding of t PA/PAI 1 complexes to fibrin mediated by both the finger and the kringle 2 domain of t PA
... urokinase-type plasminogen activator ...by plasminogen activator inhibitor type 1 (PAI-1) that is either present in plasma or bound to fibrin, present in a ...activate ...
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Molecular and cellular studies of the role of urokinase plasminogen activator in cutaneous wound healing
... poor inhibitor of sc-tPA and is unable to inhibit tPA associated with fibrin (Kruithof et al, ...of plasminogen activators by PAI-2 is typical of serpin family members, with initial high affinity ...
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Thrombophilic Mutations and Folate Gene Polymorphisms and Plasminogen Activator Inhibitor-1 in Russian Women with Unexplained Recurrent Early Spontaneous Abortion
... Results: Significant association between heterozygotes genotype FVL 1691G/A and URESA was found (OR=3.1). Heterozygous genotype FII20210G/A was associated mainly with recurrent spontaneous abortions (4% vs 0%). The PAI-1 ...
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Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival
... COX2 inhibitor or knockdown of COX2 reduced expression of casein kinase (CK) 2 a, a phophorylated Akt and urokinase type plasminogen activator (uPA), resulting in p27 induction, cell cycle ...
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A suppressive effect of prostaglandin E<sub>2</sub> on the expression of <em>SERPINE1</em>/plasminogen activator inhibitor-1 in human articular chondrocytes: An <em>in vitro</em> pilot study
... the plasminogen system in articular chondrocytes. PGE 2 suppressed PAI-1 level in human articular chondrocytes via EP4 ...PGE 2 is suggested to play an important role in the regulation of plasmin ...
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Plasminogen activator inhibitor-1 and cardiovascular risk
... In order to check the genotyping performed by the ASO method, 12 random samples were selected for direct DNA sequencing. The chain terminating method of Sanger et al (1977), with modified T7 DNA polymerase (Sequenase, ...
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Effects of pitavastatin on plasminogen activator inhibitor-1 in hyperlipidemic patients
... Fasting blood samples from patients and controls were col- lected from the peripheral veins into vacutainers containing EDTA-ACD (NIPRO Co, Ltd, Osaka, Japan) using 21-gauge needles to minimize platelet activation. The ...
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Regulation of urokinase plasminogen activator and plasminogen activator inhibitor-1 in murine breast cancer cells
... The mechanism by which coagulation proteases exert their tumor enhancing effects is, in part, via activation of protease-activated receptor (PAR)-1 and PAR-2 9-12 . PARs belong to a family of G-protein coupled ...
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Picornavirus Receptor Down-Regulation by Plasminogen Activator Inhibitor Type 2
... PAI-2-mediated picornavirus receptor down-regulation oc- curs at the transcriptional level. To ascertain whether PAI-2- induced picornavirus receptor down-regulation was mediated by transcriptional or ...
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A Plasminogen Activator Inhibitor-1 Promoter Polymorphism and Idiopathic Interstitial Pneumonia
... The study used patients from the University of Michigan Specialized Center of Research in the Pathobiology of Fibrotic Lung Disease database. Patients used for the study were required to have a surgical lung biopsy, a ...
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Plasminogen activator inhibitor 1 in acute hyperoxic mouse lung injury
... Fibrin is involved in a wide spectrum of extravascular remodel- ing processes. In wound repair, localized fibrin deposition se- cures the restoration of tissue integrity through its mechanical and biological properties. ...
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Possible Role of Plasminogen Activator Inhibitor-1 in Childhood Bronchial Asthma
... In our study the level of PAI-1 is increased with increased degree of asthma severity, which is similar to the result of CHO et al. (2016) whom concluded that a genetic variant of PAI-1 together with early life lower ...
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Usefulness of plasminogen activator inhibitor-1 as a predictive marker of mortality in sepsis
... Patients were classified into the higher group (PAI-1 level ≥83 ng/ml; n = 85) and the lower group (PAI-1 level <83 ng/ml; n = 101). DIC, SOFA scores (in particular, cardiovascular and coagulation SOFA scores), and ...
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Tissue Distribution and Regulation of Plasminogen Activator Inhibitor-1 in Obese Mice
... 6-fold) in PAI-1 mRNA expression observed in the epididymal, subcutaneous, and brown fat of the obese mice (Fig. 2) suggests that the adipose tissue itself may be a significant contribut[r] ...
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Recombinant plasminogen activator inhibitor 1 reverses the bleeding tendency associated with the combined administration of tissue type plasminogen activator and aspirin in rabbits
... tissue-type plasminogen activator (rt-PA) on serial template bleeding times and on hemostasis parameters in ...for 2 h) lengthened the bleeding time from ...for 2 h prolonged the bleeding time ...
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Beta-amyloidolysis and glutathione in Alzheimer's disease
... its inhibitor, plasminogen activator inhibitor (PAI-1), and occurs without any modification in the normal values of alpha-2 antiplas- ...
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Plasminogen activator inhibitor-1, free fatty acids, and insulin resistance in patients with myocardial infarction
... In contrast, fasting serum insulin and C-peptide levels tended to increase in both groups on the 1st and 12th days from MI onset, but did not differ significantly from the control values (Table 3). The changes in ...
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A study on factors influencing the Outcome of Thrombolysis in Acute Myocardial Infarction
... plasminogen activator inhibitor from endothelium enhancement of plasminogen activation by f-fibrin and plasmin inhibiton by alpha 2 antiplasmin ...for plasminogen and ...
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Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population
... tissue plasminogen activator ...specific inhibitor of t-PA in plasma, plasminogen activator Table 2 Genotypic distribution of the t-PA and PAI-1 gene between TLE patients and ...
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High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study
... type 2 diabetes in long-time follow up of population samples, although adjusting for measurements of obesity attenu- ates the relationship ...of plasminogen activator inhibitor-1 (PAI-1) were ...
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