plasminogen activator protein-1
Expression of deleted in liver cancer 1 and plasminogen activator inhibitor 1 protein in ovarian carcinoma and their clinical significance
... [7]. Plasminogen activator inhibitor 1 (PAI-1) is the key inhibitor of the plasminogen activation system (PAS), PAI-1 participate in the pathophysiology of a num- ber of diseases ...
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Role of urokinase plasminogen activator and plasminogen activator inhibitor mRNA expression as prognostic factors in molecular subtypes of breast cancer
... uPA and PAI-1 protein levels were compared according to published cutoffs (uPA, 3 ng/mg protein; PAI-1, 14 ng/mg protein). For survival analysis, patient cohorts A and B were stratified ...
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Behçet’s disease: new insight into the relationship between procoagulant state, endothelial activation/damage and disease activity
... C-reactive protein (CRP) was measured by nephelomet- ric method (Behring Nephelometer Analyzer, ...minogen activator (t-PA) (TriniLIZE tPA antigen ELISA kit) and plasminogen activator ...
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Key words
... of plasminogen to plasmin [2, ...the plasminogen-to-plasmin conversion ...minogen activator (pro-u-PA, single chain uroki- nase plasminogen activator: scu-PA) which is trans- formed ...
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Targeted expression of plasminogen activator inhibitor(PAI)-1 to the stomach inhibits gut-brain signalling by the satiety hormone cholecystokinin (CCK)
... Debas et al. first reported that CCK played an important physiological role in the delay of gastric emptying (Debas et al., 1975). Gastric emptying is dependent on the resistance to flow at the pylorus and on the ...
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Association of dietary soy with expression of various pro-inflammatory genes in porcine phagocytes
... as protein sources in pig feeding (Yang et ...urokinase-plasminogen activator (u-PA), u-PA receptor (u- PAR), plasminogen activator inhibitor type 1 and 2 (PAI-1, PAI-2), ...
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Regulation of urokinase plasminogen activator and plasminogen activator inhibitor-1 in murine breast cancer cells
... More than a century ago, Armand Trousseau first described an association between cancer and the coagulation system 1,2 . Later it was discovered that tumor cells release procoagulant microvesicles (often referred to as ...
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The regulation of tissue plasminogen activator in rat brain glioma cells
... A correlation betw een PA and its inhibitor is also seen in som e o f the rat tissu es exam ined by L ucore et al. (1988) w here it was found that those tissue expressing high levels o f PA also co n tain ed elev ated PA ...
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Integrin dependent induction of functional urokinase receptors in primary T lymphocytes
... gen activator/plasmin system in normal T cell ...urokinase plasminogen activator (uPAR) were not expressed in resting T lymphocytes, but could be efficiently induced at the mRNA and protein ...
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Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness
... fibrinolytic protein, is formed when plasminogen activators cleave the inert precursor zymogen, ...plasminogen. Plasminogen activator activity is constrained by plasminogen ...
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High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study
... C-reactive protein, have been found to predict type 2 diabetes in long-time follow up of population samples, although adjusting for measurements of obesity attenu- ates the relationship ...of plasminogen ...
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Coordinated induction of plasminogen activator inhibitor 1 (PAI 1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition
... Because our in vivo studies point strongly to macrophages both within the alveolus and within the vasculature as the chief source of PAI-1 in hypoxic murine lung, confirmation of hyp- oxia-induced PAI-1 ...
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"Hypoxia induced down regulation of microRNA 449a/b impairs control over targeted SERPINE1 (PAI 1) mRNA a mechanism involved in SERPINE1 (PAI 1) overexpression"
... b 1-3) and bone morphogenetic proteins (BMPs) ...the plasminogen activator urokinase-type (uPA) and -tissue-type (tPA) which mediate proteolysis of ECM components but also activation of latent, ...
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Extracellular proteolysis in the adult murine brain
... the plasminogen activator/plasmin system in the adult murine central nervous ...Tissue-type plasminogen activator is synthesized by neurons of most brain regions, while prominent tissue-type ...
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Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects
... table 1. The fibrinolytic para- meters, PAI-1 and tPA activities and antigens and tPA/ PAI-1 complex assessed by general linear model (uni- variate) are shown in table ...
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Thrombin induction of plasminogen activator inhibitor in cultured human endothelial cells
... endothelial cell cultures with thrombin for 24 h caused a sixfold increase in PA-I activity. The effect of thrombin was half-maximal at approximately 0.4 U/ml (less than 4 nM), and required concomitant RNA and ...
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alpha Fucose mediated binding and degradation of tissue type plasminogen activator by HepG2 cells
... Binding and degradation of tissue-type plasminogen activator by the human hepatoma cell line HepG2.. Interactions between tissue-type plasminogen activator and extracellular matrix assoc[r] ...
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Interaction between plasminogen activator inhibitor type 1 (PAI 1) bound to fibrin and either tissue type plasminogen activator (t PA) or urokinase type plasminogen activator (u PA) Binding of t PA/PAI 1 complexes to fibrin mediated by both the finger and the kringle 2 domain of t PA
... urokinase-type plasminogen activator ...by plasminogen activator inhibitor type 1 (PAI-1) that is either present in plasma or bound to fibrin, present in a ...activate ...
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Effects of pitavastatin on plasminogen activator inhibitor-1 in hyperlipidemic patients
... a correlation between adiponectin and PAI-1 in previous stud- ies. Nevertheless, when the patients of the pitavastatin group were divided into two subgroups according to the adiponectin response to pitavastatin ...
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Structural and kinetic comparison of recombinant human single and two chain tissue plasminogen activator
... tissue plasminogen activator (sct-PA) and two-chain tissue plasminogen activator (tct-PA), and compared these structural data with measurement of enzymatic ...intrinsic protein ...
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