plasminogen activator(s)
Role of urokinase plasminogen activator and plasminogen activator inhibitor mRNA expression as prognostic factors in molecular subtypes of breast cancer
... nase plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in fresh-frozen tumor tissue from primary breast cancers by a commercially available ...
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Interaction between plasminogen activator inhibitor type 1 (PAI 1) bound to fibrin and either tissue type plasminogen activator (t PA) or urokinase type plasminogen activator (u PA) Binding of t PA/PAI 1 complexes to fibrin mediated by both the finger and the kringle 2 domain of t PA
... urokinase-type plasminogen activator ...by plasminogen activator inhibitor type 1 (PAI-1) that is either present in plasma or bound to fibrin, present in a ...activate plasminogen. Upon ...
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High levels of tissue plasminogen activator (tPA) antigen precede the development of type 2 diabetes in a longitudinal population study. The Northern Sweden MONICA Study
... of plasminogen activator inhibitor-1 (PAI-1) were strongly related to the development of diabetes independ- ent from insulin resistance and obesity ...tissue plasminogen activator (tPA) or the ...
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Thrombolysis with Human Extrinsic (Tissue Type) Plasminogen Activator in Rabbits with Experimental Jugular Vein Thrombosis EFFECT OF MOLECULAR FORM AND DOSE OF ACTIVATOR, AGE OF THE THROMBUS, AND ROUTE OF ADMINISTRATION
... (tissue-type) plasminogen activator, highly purified from the culture fluid of a human melanoma cell line, was administered systemically or locally over a time period of 4 h and the percent thrombolysis ...
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Molecular and cellular studies of the role of urokinase plasminogen activator in cutaneous wound healing
... the plasminogen activator system is important in cellular m igration and tissue rem ...the plasminogen activator system may be modulating the activity of uPA, and indicating that this ...
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Tissue type plasminogen activator increases the binding of glu plasminogen to clots
... tissue-type plasminogen activator (t-PA) increases the binding of 125I-glu- plasminogen to clots made from human plasma or purified fibrinogen in a time and t-PA concentration dependent ...of ...
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A nonantigenic covalent streptokinase polyethylene glycol complex with plasminogen activator function
... of plasminogen by streptokinase, PEG-2-streptokinase, and ...with plasminogen also was studied as a function of time with each of the PEG-streptokinase ...with plasminogen at a 1:1 molar ratio was ...
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Structural and kinetic comparison of recombinant human single and two chain tissue plasminogen activator
... tissue plasminogen activator (sct-PA) and two-chain tissue plasminogen activator (tct-PA), and compared these structural data with measurement of enzymatic ...
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Regulation of urokinase plasminogen activator and plasminogen activator inhibitor-1 in murine breast cancer cells
... urokinase plasminogen activator (uPA) and plasminogen activator inhibitor (PAI)-1 in two murine mammary adencocarcinoma cell lines: metastatic 4T1 cells and non-metastatic 67NR ...
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Tissue-Type Plasminogen Activator, Plasminogen Activator Inhibitor, and Histidine-Rich Glycoproteins in Stressed Human Newborns
... Tissue-type plasminogen activator antigen was determined by an enzyme-linked immuno- sorbent assay (ELISA) method using a commercial kit (Imubind-5- tPA, American Diagnostica).4’9 Plasmi[r] ...
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Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness
... when plasminogen activators cleave the inert precursor zymogen, ...plasminogen. Plasminogen activator activity is constrained by plasminogen activator ...
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Thrombin induction of plasminogen activator inhibitor in cultured human endothelial cells
... of plasminogen activator (PA) and plasminogen activator-inhibitor (PA-I) in medium conditioned by primary cultures of human umbilical vein endothelial ...
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Aspirin inhibits vascular plasminogen activator activity in vivo Studies utilizing a new assay to quantify plasminogen activator activity
... Vascular or tissue-type plasminogen activator (TPA) is a key enzyme in physiologic fibrinolysis. To study the role of prostaglandins in modulating the synthesis and release of TPA in vivo, we prospectively ...
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alpha Fucose mediated binding and degradation of tissue type plasminogen activator by HepG2 cells
... Binding and degradation of tissue-type plasminogen activator by the human hepatoma cell line HepG2.. Interactions between tissue-type plasminogen activator and extracellular matrix assoc[r] ...
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Targeted expression of plasminogen activator inhibitor(PAI)-1 to the stomach inhibits gut-brain signalling by the satiety hormone cholecystokinin (CCK)
... “Plasminogen Activator Inhibitor PAI-1 inhibits the satiety effect of Cholecystokinin CCK Through a Mechanism Requiring the Urokinase Plasminogen Activator Receptor uPAR.”.. Joanne Gambl[r] ...
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The regulation of tissue plasminogen activator in rat brain glioma cells
... y s show th a t tP A m R N A is expressed in the A15A5 cells although w ith a lag in tim ...lead s to a tran sien t degradation of the m essage irresp e ctiv e o f w hether serum is p resent or ...
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Isolation from human plasma of a plasminogen activator identical to urinary high molecular weight urokinase
... plasmatic plasminogen activators (PA) can be demonstrated after sodium dodecyl sulfate polyacrylamide gel electrophoresis of plasma freshly collected from resting volunteers, followed by transfer of the gels onto ...
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Behçet’s disease: new insight into the relationship between procoagulant state, endothelial activation/damage and disease activity
... minogen activator (t-PA) (TriniLIZE tPA antigen ELISA kit) and plasminogen activator inhibitor type 1 (PAI-1) (TriniLIZE PAI-1 antigen ELISA kit); all kits were ac- quired from Trinity Biotech, Bray, ...
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Inhibition of angiogenesis by platelets in systemic sclerosis patients
... minogen activator, plasminogen activator inhibitor type 1, and platelet-derived growth factor in patients with Raynaud’s phenomenon associated with scleroderma than in control subjects, suggesting ...
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The plasminogen activator/plasmin system
... However, the concept of proteolytic activation of hormones and growth factors should be revisited in the light of recent studies: plasmin can activate the latent form of TGF,3 and releas[r] ...
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