Plasmodium berghei
Evaluation of antiplasmodial effects of the ethanolic leaf extract of Salacia lehmbachii on Plasmodium berghei infected mice
... Salacia lehmbachii leaves are used in Nigerian traditional medicine for the treatment of malaria and other diseases. The ethanolic extract was tested for its activities against suppressive, prophylactic and established ...
7
IN VIVO ANTIMALARIAL ACTICITY OF METHANOLIC EXTRACT OF YOUNG FRONDS OF PTERIDIUM AQUILINUM L. KUHN IN MICE INFECTED WITH PLASMODIUM BERGHEI
... sensitive plasmodium berghei infection in mice, with a view to finding scientific evidence for the use of this plant as traditional remedy for malaria ...P. berghei infected mice in both the early ...
7
Anti malarial activity of the root extract of Euphorbia abyssinica (Euphorbiaceae) against Plasmodium berghei infection in mice
... Methods: The fresh roots of Euphorbia abyssinica were identified and collected. They were dried and extracted by 80% methanol using maceration. Acute toxicity of the extract was done using female Swiss albino mice. ...
8
Development of a Plasmodium berghei transgenic parasite expressing the full length Plasmodium vivax circumsporozoite VK247 protein for testing vaccine efficacy in a murine model
... transgenic Plasmodium berghei parasite line [PvCSP(VK210)/Pb] generated previously expresses the full-length circumsporozoite protein (CSP) VK210 from Plasmodium ...P. berghei parasite line ...
8
Selection of drug resistant mutants from random library of Plasmodium falciparum dihydrofolate reductase in Plasmodium berghei model
... as Plasmodium berghei are attractive models for human malaria, and the recent advances in DNA transfection technology allow for genetic modification of the parasite ...P. berghei, and thus transgenic ...
7
Pre infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague Dawley rats
... anti-inflammatory [13] and immunomodulatory [14] activities. Chemically known as (4α)-2α, 3β, 23-trihy- droxy-urs-12-en-28-oic acid, having redox reaction capa- bility, amphiphilic with a hydrogen bond donor/acceptor ...
10
Preliminary Study: Neurobehavioural Effects of Nauclea latifolia and Emilia sonchifolia in Mice Infected with Plasmodium berghei berghei
... area is very large relative to the animal). In Fig. 5, the initial freezing duration (FD) was significantly (p<0.05) increased in Groups 4, 5 and 6 compared to the control, but was subsequently decreased in the final ...
10
Antimalarial activity of 80 % methanolic extract of Brassica nigra (L ) Koch (Brassicaceae) seeds against Plasmodium berghei infection in mice
... Plasmodium berghei four-day suppressive test, the most widely used preliminary test, in which the efficacy of four daily doses of new compounds is measured by comparison of blood parasitaemia and survival ...
8
ANTIMALARIAL ACTIVITY OF CRYPTOLEPIS SANGUINOLENTA BASED HERBAL CAPSULES IN PLASMODIUM BERGHEI INFECTED MICE
... Two Cryptolepis sanguinolenta based herbal capsules prepared at the Centre for Scientific Research into Plant Medicine, Mampong- Akwapim, Ghana, were evaluated for antiplasmodial activity using Plasmodium ...
5
AN IN VIVO EVALUATION OF ANTIPLASMODIAL ACTIVITY OF AQUEOUS AND ETHANOLIC LEAF EXTRACTS OF AZADIRACHTA INDICA IN PLASMODIUM BERGHEI INFECTED BALB/c MICE
... Malaria remains one of the most prevalent infections in the tropical regions of the world. The increased resistance of the parasite to many available antimalarials backs the need to develop novel antimalarial drugs with ...
5
Differential induction of malaria liver pathology in mice infected with Plasmodium chabaudi AS or Plasmodium berghei NK65
... lethal Plasmodium berghei strain NK65 and self-healing Plasmodium chabaudi strain AS which differ in their ability to cause hepatopathy and/or ARDS were used to investigate the lipid alterations, ...
9
Impact of chrysosplenetin on the pharmacokinetics and anti malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome
... Background: Artemisinin (ART) is an efficacious and safe anti-malarial drugs but has low oral bioavailability and auto-induction profiles during multiple dosing. The pharmacokinetic disadvantages have been found to ...
13
Overexpression of Plasmodium berghei ATG8 by Liver Forms Leads to Cumulative Defects in Organelle Dynamics and to Generation of Noninfectious Merozoites
... single Plasmodium berghei orthologs of ATG8, ATG3, and ATG7 ...P. berghei, PbATG8 localizes to a network of vesicles and tubules that align along the apicoplast, a relict plastid organelle, as well ...
24
Excess Fibrin Deposits Decrease Fetal Weight of Pregnant Mice Infected by Plasmodium berghei
... The BALB/c mice were obtained from Universitas Gadjah Mada and maintained in conventional housing at the Parasitology Laboratory Faculty of Medicine Universitas Brawijaya. Infection experiments were performed in adult ...
5
Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice
... of Plasmodium falciparum infections. In the Plasmodium berghei ANKA (PbA) murine model, CM is associated with marked brain inflammation, increased expression of endothelial cell adhesion molecules ...
9
Parasite densities modulate susceptibility of mice to cerebral malaria during co infection with Schistosoma japonicum and Plasmodium berghei
... A number of studies have documented that CM re- sults from a predominant Th1 response. Besides, a num- ber of pro-inflammatory cytokines, including IFN-γ and relatively lower levels of anti-inflammatory cytokines, such ...
11
Antiplasmodial activity of methanol leaf extract of Salacia senegalensis Lam (Dc) in Albino Mice infected with chloroquine-sensitive Plasmodium berghei berghei (NK65)
... against Plasmodium berghei infection in Swiss albino mice was evaluated as to support or discourage its use in the treatment of malaria in Nigeria folk ...
6
IN VIVO EFFECT OF IRON SUPPLEMENT ON PARASITAEMIA IN MICE INFECTED WITH NK 65 STRAIN OF PLASMODIUM BERGHEI AND TREATED WITH ARTESUNATE: A PRELIMINARY STUDY
... of Plasmodium berghei and treated with ...of Plasmodium berghei) and treated with either Artesunate (Art) only or with a combination of ferrous sulphate supplement (Fe) and parasitaemia was ...
5
Influence of midgut microbiota in Anopheles stephensi on Plasmodium berghei infections
... Studies have also shown the impact of midgut bacte- ria on the development of Plasmodium in the mosquito host. The Enterobacter bacterium (Esp_Z) isolated by Cirimotich et al. [12] from field-caught Anopheles ara- ...
8
Isolation of Plasmodium berghei ookinetes in culture using Nycodenz density gradient columns and magnetic isolation
... CD mice were treated with phenylhydrazine two days prior to infection by intra peritoneal inoculation with P. berghei ANKA strain, obtained from a donor mouse between the second and sixth passage from ...
6