Plasmodium Berghei Anka
Germinal center architecture disturbance during Plasmodium berghei ANKA infection in CBA mice
... The Plasmodium berghei ANKA infection of CBA mouse is an established model of malaria with neu- rological involvement (the so-called experimental cere- bral malaria), and infection with blood stage ...
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Tim 3 signaling blockade with α lactose induces compensatory TIGIT expression in Plasmodium berghei ANKA infected mice
... in Plasmodium berghei ANKA-infected ...against Plasmodium infection, and blocking Tim-3-galectin 9 signaling using α-lactose did not significantly protect the mice; however, it induced the ...
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REVIEW ARTICLE Changes in brain metabolites in experimental cerebral malaria infection with plasmodium berghei ANKA: A literature review
... PbA= Plasmodium berghei ANKA, CT= computerized tomography, MRI= magnetic resonance imaging, FLAIR= fluid attenuated inversion recovery, FAIR=flow alternating arterial inversion, fMRI= functional ...
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Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice
... In the Plasmodium berghei ANKA (PbA) murine model, CM is associated with marked brain inflammation, increased expression of endothelial cell adhesion molecules and leukocyte and platelet[r] ...
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Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection
... (GFP)-expressing Plasmodium berghei ANKA iRBCs [20] by intra-peritoneal (i.p.) injection, after one passage through mice infected from a frozen vial. Peripheral blood parasi- taemia was determined by ...
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Lambda carrageenan treatment exacerbates the severity of cerebral malaria caused by Plasmodium berghei ANKA in BALB/c mice
... Background: There is an urgent need to develop and test novel compounds against malaria infection. Carrageenans, sulphated polysaccharides derived from seaweeds, have been previously shown to inhibit Plasmodium ...
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Upper gastrointestinal pathophysiology due to mouse malaria Plasmodium berghei ANKA infection
... Mice infected with P. berghei ANKA (PbA) [9] are widely used as a mouse model of malaria infection. PbA-infected C57BL/6 (PbA-C57BL/6) mice are the best-known cerebral malaria models [10, 11], and diag- ...
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Elevated IL 17 levels in semi immune anaemic mice infected with Plasmodium berghei ANKA
... against Plasmodium infection through low ...the Plasmodium infection may be more of a Th1 response at low Hb (Hbm) where F1 and Balb/c start clearing the parasites without treatment ...
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Antimalarial efficacy of Pongamia pinnata (L) Pierre against Plasmodium falciparum (3D7 strain) and Plasmodium berghei (ANKA)
... morphological alterations and damage to the erythrocytes after 48 h of incubation. Because methanolic bark extract of Pongamia pinnata has shown good antimalarial activity in vitro, it was also tested in vivo. So the ...
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Plasmodium berghei ANKA infection increases Foxp3, IL 10 and IL 2 in CXCL 10 deficient C57BL/6 mice
... It was observed in this study that IL-10 levels increased in plasma during P. berghei infection in CXCL-10-/- than in wild type mice. Interleukin-10 (IL- 10) is an anti-inflammatory cytokine and thus increased ...
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In vitro culture of Plasmodium berghei ANKA maintains infectivity of mouse erythrocytes inducing cerebral malaria
... Figure 1 Aspect of in vitro culture of P. berghei in mouse erythrocytes. A/Follow up of the cultures. Schizonts burst and reinvasion is followed up on Giemsa-stained thin smears. Late stage (arrow head), early ...
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Immunization of mice with soluble lysate of interferon gamma expressing Plasmodium berghei ANKA induces high IFN-γ production
... With the advancement in transfection technology for malaria parasites, mIFN-γ expressing PbA has recently been generated in the malaria lab at Institute of Primate Research (IPR) [12]. This transgenic PbA (TPbA) has been ...
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Effect of chronic khat (Catha edulis, Forsk) use on outcome of Plasmodium berghei ANKA infection in Swiss albino mice
... However, in mice treated with khat extract, under all doses, followed by PbA infection, significant increment P < 0.05 in level of UA than the positive control was observed, while signif[r] ...
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Long term effect of uncomplicated Plasmodium berghei ANKA malaria on memory and anxiety like behaviour in C57BL/6 mice
... P. berghei NK65 infection of C57BL/6 mice [45], and, moreover, pre- liminary data shows that no blood-brain barrier breakdown is observed on day 4 in the PbA-C57BL/6 model studied here (unpublished ...
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Antioxidant Activities of Ethanoilc Extracts of Spilanthes uliginosa, Ocimum basilicum, Hyptis spicigera and Cymbopogon citratus against Swiss Mice Exposed to Plasmodium berghei Anka 65
... in Plasmodium berghei treated mice as observed in this study indicated antioxidant depletion result- ing in damage to the hepatic cells by free radicals generated ...in Plasmodium berghei- ...
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Parasite densities modulate susceptibility of mice to cerebral malaria during co infection with Schistosoma japonicum and Plasmodium berghei
... A number of studies have documented that CM re- sults from a predominant Th1 response. Besides, a num- ber of pro-inflammatory cytokines, including IFN-γ and relatively lower levels of anti-inflammatory cytokines, such ...
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In vivo validation of anti malarial activity of crude extracts of Terminalia macroptera, a Malian medicinal plant
... P. berghei, administration of TML or TMR to mice induced similar weight changes compared to CQ or vehi- cle at D4, strengthening the safety of TML and TMR at the tested ...of Plasmodium berghei ...
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Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization
... in Plasmodium berghei ANKA strain were constructed based on the se- quence of pL0017 vector (The Malaria Research and Reference Reagent Resource Center; MR4), which con- tains Toxoplasma gondii ...
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Integrin αDβ2 (CD11d/CD18) mediates experimental malaria associated acute respiratory distress syndrome (MA ARDS)
... the Plasmodium berghei ANKA model of MA-ARDS has features similar to those in humans with clinical MA- ARDS [19, 21], including increased permeability pulmo- nary oedema, vascular and interstitial ...
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Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria
... Cerebral malaria (CM) is a major cause of death in African children infected with Plasmodium falciparum (1). This seri- ous neurological condition is characterized by the seques- tration of parasitized ...
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