Platelet Activating Factor (PAF)
Platelet activating factor: mediator of the third pathway of platelet aggregation? A study in three patients with deficient platelet activating factor synthesis
... A Sturk, … , H Przyrembel, P Borst J Clin Invest. 1987;79(2):344-350. https://doi.org/10.1172/JCI112818. Thrombin, collagen, and Ca2+-ionophore A23187 aggregate platelets in the presence of inhibitors of the first ...
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Occupancy of platelet receptors for platelet activating factor in patients with septicemia
... of platelet-activating factor (PAF) in the pathogenesis of endotoxemia, was investigated by using a binding assay to patients' platelets, complemented with the extraction and chemical ...
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Deficiency of platelet activating factor acetylhydrolase is a severity factor for asthma
... Received for publication October 21, 1998, and accepted in revised form February 17, 1999. Asthma, a family of airway disorders characterized by airway inflammation, has an increasing incidence worldwide. ...
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Radiation therapy generates platelet-activating factor agonists
... PAF, platelet-activating factor; PAcPC, 1-palmitoyl-2-acetyl-GPC; BPAF, 1-O-hexadecyl-2-butanoyl-GPC; PBPC, 1-palmitoyl-2-butanoyl-GPC; PPrPC, 1-palmitoyl-2-propanoyl-GPC; PHPC, ...
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Metabolism of platelet activating factor in isolated perfused rat lung
... of platelet-activating factor (PAF) into the airway system of the lung is known to cause profound effects, yet little is known about the metabolism of this active lipid ...
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Molecular and cellular actions of platelet activating factor in rat heart cells
... Platelet-activating factor (PAF) is a phospholipid with cardiovascular actions at low concentrations (1-100 nM) but with uncertain direct myocardial ...
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Altered Platelet Activating Factor Metabolism in Insulin Dependent Diabetes Mellitus
... of platelet activating factor (PAF), a potent inducer of platelet aggregation, is elevated in insulin dependent diabetes mellitus (IDDM) and remains unchanged in non-insulin dependent diabetes ...
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Platelet-Activating Factor-Acetylhydrolase Can Monodeacylate and Inactivate Lipoteichoic Acid
... Ho Seong Seo, 2 Je Hak Kim, 1 and Moon H. Nahm 1,2 * Departments of Pathology 1 and Microbiology, 2 University of Alabama at Birmingham, Birmingham, Alabama Received 29 September 2005/Returned for modification 8 December ...
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Platelet activating factor levels and metabolism in tangier disease: a case study
... infiltration into the arterial wall (1), where the lipoproteins undergo oxidation (2) and the monocyte-derived macro- phages after digestion of modified lipoprotein particles form foam cells [9]. Macrophages, after their ...
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Platelet activating factor mediates interleukin 2 induced lung injury in the rat
... Interleukin-2 was recently shown to cause acute lung injury characterized by microvascular permeability defect, interstitial edema, and leukosequestration. Similar responses can also be produced by platelet ...
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Impact of prostaglandin glaucoma drops on platelet-activating factor action: an in vitro study
... glaucoma, platelet-activating factor, prostaglandin analogs, treatment, platelet aggregation Introduction Glaucoma is estimated to be the second leading cause of severe vision loss and ...
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Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells
... Platelet-activating factor (PAF), prostaglandins (PGs), and lysophosphatidic acid (LPA) are the three major phospho- lipid mediators implicated in many different biological pathways in inflammatory ...
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Absence of platelet activating factor receptor protects mice from osteoporosis following ovariectomy
... While platelet-activating factor (PAF) is produced in various diseases associated with bone resorption, its functions in bone metabolism remain ...
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Platelet activating factor mediates acid induced lung injury in genetically engineered mice
... E-mail: [email protected]; URL: http://www.biochem2.m.u-tokyo.ac.jp. Received for publication June 30, 1999, and accepted in revised form September 1, 1999. Adult respiratory distress syndrome (ARDS) is an acute ...
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Vitamin C blocks inflammatory platelet activating factor mimetics created by cigarette smoking
... by platelet-activating factor (PAF) receptor antagonists, and correlates with the accumulation of PAF-like mediators in the blood of cigarette smoke–exposed ...
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Role of platelet activating factor in Chinese hamster ovary cell responses to cholera toxin
... CO 2 at 37 8 C as previously described (8). Cholera toxin, with or with- out the PAF receptor antagonists BN52021 or SR27417, prostaglan- din E 1 , prostaglandin E 2 , or platelet activating factor ...
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Oxygen radicals inhibit human plasma acetylhydrolase, the enzyme that catabolizes platelet activating factor
... J Clin Invest. 1994;93(6):2408-2416. https://doi.org/10.1172/JCI117248. Platelet-activating factor (PAF) can exert profound inflammatory effects at very low concentrations. In plasma, PAF is ...
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Interleukin 1 stimulates platelet activating factor production in cultured human endothelial cells
... Monocyte-derived interleukin 1 (IL-1) was found to be a potent inducer of platelet-activating factor (PAF) in cultured human vascular endothelial cells (HEC).. The product was identified[r] ...
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Exploring the plasmatic platelet-activating factor acetylhydrolase activity in patients with anti-phospholipid antibodies
... Platelet-activating factor acetylhydrolase (PAF-AH) is a family of enzymes, the most abundant of which is the plasma form, also called lipoprotein-associated phospho- lipase A2 (Lp-PLA2) ...important ...
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Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage
... using platelet-activating factor (PAF) antagonists have indicated that PAF is involved in neuronal loss fol- lowing human immunodeficiency virus infection [7], in kainic acid-induced epilepsy models ...
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