Platelet membrane glycoprotein
Original Article Association between platelet membrane glycoprotein polymorphisms and risk of coronary heart disease
... [4]. Platelet membrane glycoprotein receptors mediate cru- cial reactions in acute thrombosis and chronic processes of atherogenesis ...of platelet membrane glycoprotein and CHD ...
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An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system
... human platelet membrane glycoprotein (GP) IIIa, and has previously been implicated in the onset of two important clinical syndromes, neonatal alloimmune thrombocytopenic purpura and posttransfusion ...
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Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody
... molecules/platelet for LJP9 (range of 11 and 10 experiments, respectively). Binding increased up to 50% after thrombin stimulation. The estimated association constant, Ka, was 2.7 X 10(7) M-1 for LJP5 and 3.85 X ...
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Original Article Association between polymorphisms of platelet membrane glycoprotein Ibα and risk of coronary heart disease in Han Chinese, Henan, China
... human platelet antigen-2 (HPA-2) system, char- acterized by a C/T transition at nucleotide 1018 and result that an amino acid dimorphism (Thr/Met) at residue 145 [8]; second, the Kozak sequence contains a single ...
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Isolation and Quantitation of the Platelet Membrane Glycoprotein Deficient in Thrombasthenia Using a Monoclonal Hybridoma Antibody
... abnormality in Glanzmann's thrombasthenia. Spleen cells from Balb/c mice immunized with human platelets were fused to mouse myeloma cell line Sp2/0-Ag14. Hybridoma lines producing a variety of antiplatelet antibodies ...
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Platelet membrane glycoprotein IIIa contains target antigens that bind anti platelet antibodies in immune thrombocytopenias
... with platelet destruction, and the ubiquitous presence of nonspecific, platelet-associated ...specific membrane protein that bears target platelet antigens in immune ...on glycoprotein ...
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Characterization of the platelet membrane glycoprotein abnormalities in Bernard Soulier syndrome and comparison with normal by surface labeling techniques and high resolution two dimensional gel electrophoresis
... The platelets from three patients with Bernard-Soulier syndrome have been analyzed by surface-labeling coupled with two-dimensional gel electrophoresis and compared with normals. As well as the previously described ...
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Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia
... heterodimer, because it occurred at 22 degrees C and in response to mM magnesium as well as calcium. PMI-1 binding inversely correlated with fibrinogen binding. In addition, we identified a variant of Glanzmann's ...
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Low shear stress can initiate von Willebrand factor dependent platelet aggregation in patients with type IIB and platelet type von Willebrand disease
... by platelet membrane glycoprotein (GP) IIb-IIIa and fibrinogen, whereas aggregation induced by high shear stress (108 dyn/cm2) requires the binding of von Willebrand factor (vWF) to both GPIb-IX and ...
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Platelet storage results in a redistribution of glycoprotein Ib molecules Evidence for a large intraplatelet pool of glycoprotein Ib
... Platelet membrane glycoprotein (GP) Ib contains receptor for von Willebrand factor and ...of platelet concentrates for 5 d resulted in a 221% increase in plasma glycocalicin ...in ...
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Clinical Outcomes of Low Dose Methotrexate Therapy as a Second Line Drug for Intravenous Immunoglobulin Resistant Kawasaki Disease
... Patients with persistent fever despite an initial treatment with IVIG received repeat IVIG and IV dexamethasone (0.3 mg/kg for 2−3 days) at the same dose. Nonetheless, 75 patients con- tinued to have fever. We repeated ...
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Binding of Dipyridamole to Human Platelets and to α1 Acid Glycoprotein and its Significance for the Inhibition of Adenosine Uptake
... acid glycoprotein of plasma, the binding of dipyridamole to human platelets is ...in platelet nucleotides and reduces the [ 14 C]-ATP to [ 14 C]ADP ...acid glycoprotein reverses these effects of ...
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Diagnosis of Bernard Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood
... In one of these disorders, Bernard-Soumembrane glycoproteins, we developed a to platelet lier syndrome, the platelets lack the platelet membrane assay that can be performed semiquantitat[r] ...
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Deficiency of a surface membrane glycoprotein (Mo1) in man
... surface glycoprotein of 150,000-D had been associated with defective C3- and IgG-dependent phagocytosis in a patient with recurrent bacterial ...surface membrane glycoproteins: lymphocyte ...
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Retention of the glycoprotein IIb IIIa complex in the isolated platelet cytoskeleton Effects of separable assembly of platelet pseudopodal and contractile cytoskeletons
... putative platelet fibrinogen receptor (glycoprotein IIb- III(a) with the cytoskeleton, 125I-surface labeled human platelets washed by gel-filtration were activated under conditions which allow selective ...
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Complex formation of platelet thrombospondin with histidine rich glycoprotein
... thrombospondin-histidine-rich glycoprotein complex. Histidine-rich glycoprotein complexed with thrombospondin was capable of binding heparin and neutralizing the anticoagulant activity of heparin in ...
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An altered platelet granule glycoprotein in patients with essential thrombocythemia
... membrane in the presence of calcium, and (d) was immune precipitated by anti-glycoprotein G antisera. The combined evidence is consistent with the 170,000 reduced protein being a modified form of the normal ...
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The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing
... population, appears to be the alloantigen that most often provokes neonatal alloimmune thrombocytopenic purpura and posttransfusion purpura. The structural features of the GPIIIa molecule responsible for its antigenicity ...
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Identification of a third component of complement binding glycoprotein of human platelets
... Utilizing affinity chromatography, a C3-specific binding protein was isolated from 125I surface-labeled human platelets. Analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis demonstrated two bands with ...
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Cleavage of protein S by a platelet membrane protease
... Protein S is a vitamin K-dependent glycoprotein cofactor to the serine protease, activated protein C. In this study we demonstrate that 125I-protein S bound to unstimulated platelets in a time- and ...
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