Platinum resistance
Similar chromosomal changes in cisplatin resistant and oxaliplatin resistant sublines of the H69 SCLC cell line are not associated with platinum resistance
... as resistance normally ...by platinum drug treatment contributes to platinum resistance; we have analysed H69 SCLC cells and two low-level platinum-resistant sublines, H69CIS200 and ...
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Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance
... to platinum-based therapy. β-catenin knockdown reversed platinum resistance and decreased stem cell frequency, which was associated with a decrease in the expression of stem cell markers like LEF-1 ...
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Copper transporting P type adenosine triphosphatase (ATP7A) is associated with platinum resistance in non small cell lung cancer (NSCLC)
... the platinum resistance of A549/DDP is due to decreased drug ...in platinum-resistance in some ...fered resistance to DDP, CBDCA and L-OHP by sequestering platinum analogues in ...
9
Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation
... of platinum resistance, here we examined the changes in global gene expression before and after platinum ...acquired platinum resistance, were assessed by microarray, and the ubiquitin ...
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Secondary BRCA1 Mutations in BRCA1-Mutated Ovarian carcinomas with platinum resistance.
... to platinum compounds, such carcinomas eventually develop platinum ...acquired resistance to cisplatin in BRCA2-mutated tumors can be mediated by secondary intragenic mutations in BRCA2 that restore ...
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A metabolomic approach to identifying platinum resistance in ovarian cancer
... of platinum has been shown to be due to the formation of intra-strand DNA adducts, which are irreparable and will eventually lead to cell apoptosis ...used platinum-compound chemotherapy, is known to induce ...
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RING domain–deficient BRCA1 promotes PARP inhibitor and platinum resistance
... cells were initially sensitive to PARPi and cisplatin but readily acquired resistance. PARPi- and cisplatin-resistant clones did not harbor secondary reversion mutations; rather, PARPi and platinum ...
14
<p>Reversing platinum resistance in ovarian cancer multicellular spheroids by targeting Bcl-2</p>
... untreated wells of a 24-well plate in triplicate. The prolifera- tion curves were made based on OD values of each well at four time points (24, 48, 72, and 96 hours) from three independent experiments. To measure the ...
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The Platinum Resistance Thermometer78-87
... The platinum resistance thermometer was develop- ed into a successful and accurate instrument by Callendar.. inherent in the method but were merely incidental to the[r] ...
10
Recent Advances in Industrial Platinum Resistance Thermometry42-47
... The wide range of shapes and sizes of platinum thermometers that these and other techniques have made possible means that an ever-increasing number of temperature [r] ...
6
Thick Film Platinum Resistance Temperature Detectors2-11
... The initial phases of development indicated that the basic problems were to resolve the materials problems inherent in meeting the basic performance criteria of BSi[r] ...
10
Platinum resistance in breast and ovarian cancer cell lines
... cellular resistance: mechan- isms of resistance are multiple and not all of them are fully ...of platinum com- pounds via heavy metal transporters, cellular comparti- mentation, detoxification of ...
11
A Thick Film Platinum Resistance Thermometer42-47
... The Matthey Thermafilm Resistance Ther- mometer is a novel temperature detector, developed from thick film technology to high standards of quality, eminently suitable as a [r] ...
6
ATP11B mediates platinum resistance in ovarian cancer
... in platinum cell ...of platinum content after 10, 20, and 30 minutes (P < ...affect platinum export in either cell ...of platinum content were determined in ATP11B-upregulated ...
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The Origin of the Platinum Resistance Thermometer104-112
... Acting on a suggestion put forward in a paper by Sir Charles Bright and his partner in the Atlantic Telegraph Company, Joseph Latimer Clark, that names should be adopted [r] ...
9
Oxaliplatin for the treatment of cisplatin resistant cancer: A systematic review
... acquire resistance to platinum drugs, many of which have been characterised in resistant cell ...of platinum resistance common to both drugs include increased cellular glutathione leading to ...
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ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair
... Homologous recombination repair is in part mediated by the RAD51 proteins [8]. A downregulation of RAD51-mediated homologous recombination repair in knockout chicken B lymphocyte DT40 cells resulted in sensitivity to ...
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THE EFFECTS OF ERCC1 EXPRESSION LEVELS ON THE CHEMORESISTANCE OF BREAST CANCER PATIENTS TREATED WITH PLATINUM BASED ADJUVANT CHEMOTHERAPY
... tumor resistance to platinum compounds is a major clinical problem in the treatment of ...of platinum resistance is complex and multifactorial, DNA repair is essential to clinical drug ...
6
Voltammetric and Impedance studies of Phenols and Its Derivatives at Carbon Nanotubes/Prussian Blue Films Platinum Modified Electrode
... The electrochemical oxidation of phenol (Ph), 4-chlorophenol (4-ClPh) and 4-nitrophenol (4-NPh) at a platinum electrode modified with and without multi-walled carbon nanotubes/Prussian blue nanocomposite in a pH ...
17
Original Article Clinical study on personalized treatment for advanced NSCLC guided by ERCC1 protein detection
... Ceppi et al. [6] detected the expression level of ERCC1 mRNA in tissues of 70 NSCLC patients. They found that patients with low ERCC1 mRNA expression had long median survival (17.3 months vs. 10.9 months, P=0.0032). ...
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