Pluripotent stem
Making gametes from pluripotent stem cells – a promising role for very small embryonic-like stem cells
... of pluripotent stem cells to give rise to tissue specific stem cells to maintain homeostasis ...and pluripotent markers [Oct-4, Nanog, Rex-1, SSEA-1 (mice) and SSEA-4 (humans)], these cells ...
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Induced pluripotent stem cells: advances to applications
... of stem cell technologies, have been based on two for- midable ...between stem cells and the host environment inherent to allogeneic stem cell sources; and second the inability to secure definitive ...
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Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells
... Mitogen-activated protein kinase (MAPK) pathway activation is involved in diverse cell-signaling functions including cell proliferation, differentiation, survival and apoptosis. Several groups have utilized photoactuated ...
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Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system
... induced pluripotent stem (iPS) cells hold great therapeutic promise for regenerative ...embryonic stem (ES) cells have yet been established, and the maintenance of pig iPS cells still depends on ec- ...
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Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons
... human pluripotent stem cells (PSCs), have jointly engendered new disease models based on induced PSCs (iPSCs) derived from the som- atic cells of patients with particular afflictions [9, ...
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Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis
... human-induced pluripotent stem cell-derived mesenchymal stem cells (hiPS-MSC-Exos) could promote angiogenesis of ischemic tissue in limb ischemia and skin defects [17, ...and stem cells in ...
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Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes
... CI: Cell index; hESC-CMs: Human embryonic stem cells-derived cardiomyocytes; hiPSC-CMs: Human induced pluripotent stem cells-derived cardiomyocytes; hPSC-CMs: Human pluripotent stem cell[r] ...
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The potential and limitations of induced pluripotent stem cells to achieve wound healing
... therapies. Stem cell therapy is emerging as a potential treatment for chronic wounds, and adult-derived stem cells are currently employed in several commercially available products; however, stem ...
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Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury
... Induced pluripotent stem cells (iPSC) are pluripotent stem cells generated by reprogramming somatic cells ...(induced pluripotent stem cell-derived mesenchymal stem cells, ...
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Induced Pluripotent Stem Cells: History, Properties and Potential Applications
... of stem cell ...induced pluripotent stem cells (iPSCs) have been shown to be greatly similar to the embryonic stem cells ...unique pluripotent property has placed them as the most ...
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Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells
... Heart development is a multistep process involving mesoderm differentiation, cardiac progenitor cell for- mation, and cardiac maturation. The in vitro differen- tiation approaches of pluripotent stem ...
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Generation of induced pluripotent stem cells from large domestic animals
... Induced pluripotent stem cells; OSKM: Oct4, Sox2, KFL4, and c-Myc; biPSCs: Bovine induced pluripotent stem cells; miPSCs: Mouse induced pluripotent stem cells; eiPSCs: Equine ...
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3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders
... The structural complexity of the human brain makes it difficult to detect all pathological conditions of neuro- logical disorders in vitro. Recruitment of vascular net- works, immune cells, or even blood-brain barrier ...
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Understanding Megakaryopoiesis And Thrombopoiesis Using Human Stem Cells Models
... Human stem cell models (CD34+ hematopoietic progenitors, embryonic stem cells and induced pluripotent stem cells (iPSCs)) are powerful tools for the study of megakaryopoiesis and ...
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An overview of mammalian pluripotency
... as pluripotent stem cells ...different pluripotent states exist, each with distinguishable molecular and functional features (Wu and Belmonte, 2016; Wu and Izpisua Belmonte, ...
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Advances in Regenerative Medicine: From Stem Cells to Organoids
... used stem cells to develop substitute tissue/organs “ex vivo” with various degree of success, which the ultimate goal is to be trans- planted to replace a damaged organ ...various stem cells, scaffold, and ...
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Understanding Regenerative Medicine and Its Position in Healthcare
... Induced pluripotent stem cells will likely focus more on disease treatment while embryonic stem cells will concentrate on debilitating injuries and degenerative disorders (Hanley, Rastegarlari, ...
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Stem cell therapies for age-related macular degeneration: the past, present, and future
... of pluripotent stem cells is not only of importance for RPE generation but will also be relevant to the production of other neuronal cell types and for reconstituting complex patterning events from ...
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p53 switches off pluripotency on differentiation
... A year later, it was observed that human adult cells were also capable of being converted into pluripotent stem cells under similar conditions [2, 3]. Due to their self-renewal and ability to differentiate ...
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BMP4 directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state
... human pluripotent stem cells (hPSCs), including embryonic (hESCs) and induced pluripotent stem cells (hiPSCs), as useful models for trophoblast differentiation; specifically, in the presence ...
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