Podocyte apoptosis
Original Article Suppression of microRNA-128 attenuates high glucose-induced podocyte apoptosis through activation of Nrf2-ARE signaling pathway
... To identify the functional target gene of miR- 128 in regulating podocyte apoptosis, we per- formed bioinformatics analysis to predict the potential targets of miR-128. Among these genes, Nrf2, an important ...
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Angiotensin II-induced podocyte apoptosis is mediated by endoplasmic reticulum stress/PKC-δ/p38 MAPK pathway activation and trough increased Na+/H+ exchanger isoform 1 activity
... to apoptosis and tissue injury ...renal apoptosis, including tubular cells and podocytes, espe- cially in diabetic nephropathy [42, ...induce podocyte ER stress via PERK-eIf2-α-ATF4 axis and ...
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<p>Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy</p>
... barrier. Podocyte injury plays a key role in the increased microalbuminuria seen in DN, which is also characterized by a signi fi cant loss in podocyte numbers due to ...inhibiting podocyte ...
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RhoA deficiency disrupts podocyte cytoskeleton and induces podocyte apoptosis by inhibiting YAP/dendrin signal
... YAP is a major downstream cascade of the Hippo pathway which controls the expression of genes that promote cell proliferation and inhibit apoptosis [20, 21]. Under normal condition, dephosphorylated YAP local- ...
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Original Article CXCR3 knockdown protects against high glucose-induced podocyte apoptosis and inflammatory cytokine production at the onset of diabetic nephropathy
... Mitochondrial dysfunction, triggered by hyper- glycemia causes excess production and accu- mulation of ROS which result in oxidative stress, is increasingly recognized as contributing to glomerular diseases and is an ...
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Astragaloside IV/lncRNA-TUG1/TRAF5 signaling pathway participates in podocyte apoptosis of diabetic nephropathy rats
... Results: Compared with control rats, DN rats had higher albuminuria and TRAF5 levels and lower TUG1 level. AS-IV treatment attenuated albuminuria and TRAF5 levels and improved TUG1 level in DN rats. TUG1 was ...
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Original Article Sodium-dependent phosphate co-transporter type IIb associates with glomerular podocyte apoptosis and injury through regulating p38 MAPK/JNK signaling pathway in mice diabetic nephropathy
... in podocyte apoptosis induced glomerular injury in diabetic ...cell apoptosis related proteins and podocyte apoptosis percentage was evaluated to inves- tigate the effect of Npt2b ...
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Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte
... attenuates podocyte damage in DN by activating klotho and inhibiting Wnt/ β -catenin pathway ...repressing podocyte apoptosis in diabetic rats ...on podocyte injury in DN and acts as a bridge ...
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Vascular endothelial growth factor A165b restores normal glomerular water permeability in a diphtheria toxin mouse model of glomerular injury
... of podocyte ablation in the Pod- DTR mice to account for this ...cell apoptosis within the glomerulus it became evident that DT-treated Pod-DTR mice had no increase in podocyte ...detectable ...
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IP3R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model
... in podocyte apoptosis. During palmitic acid-induced podocyte apoptosis, Yuan et ...mouse podocyte apoptosis induced by palmitic ...
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Development of the renal glomerulus: good neighbors and good fences
... Podocyte apoptosis is also observed in experimental models of glomerular injury (Shankland, ...affect podocyte survival. Supporting this possibility, podocyte apoptosis is increased in ...
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<p>Hirudin Protects Against Kidney Damage in Streptozotocin-Induced Diabetic Nephropathy Rats by Inhibiting Inflammation via P38 MAPK/NF-κB Pathway</p>
... Background: Inflammation-induced podocyte apoptosis plays an important role in kidney injury during diabetic nephropathy (DN). Hirudin (HIR), a natural compound extracted from leeches, can inhibit ...
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Original Article Overexpression of miR-34c inhibits high glucose-induced apoptosis in podocytes by targeting Notch signaling pathways
... HG-induced podocyte apoptosis by suppressing Bcl-2 and p53-dependent apop- totic pathways ...Notch1-mediated podocyte apoptosis ...cyte apoptosis, revealing that miR-34c is a novel ...
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Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice
... In the diabetic kidney, oxidative stress coincides with podocyte apoptosis [12]; hence, podocyte antioxidant proteins are expected to be important in protecting against diabetic nephropathy. Given ...
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The role of podocyte damage in the etiology of ischemia-reperfusion acute kidney injury and post-injury fibrosis
... increases podocyte apoptosis and results in glomerular sclerosis and renal ...of podocyte maturation ...the podocyte surface to reduce ...a podocyte pore membrane protein that has only ...
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<p>Curcumin Inhibited Podocyte Cell Apoptosis and Accelerated Cell Autophagy in Diabetic Nephropathy via Regulating Beclin1/UVRAG/Bcl2</p>
... 39,40 Podocyte apoptosis is an important pathogenic alteration that leads to podocyte loss in ...between apoptosis and DN included com- plex pathways and molecular and con fi rmed the important ...
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Podocyte injury elicits loss and recovery of cellular forces
... of podocyte cellular forces and the underlying mechanobiology preceding podocyte de- tachment in real ...contractile podocyte forces are transmitted via specific contact points formed in ...
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Mechanism of NHX1 Inhibiting TRPV5-Mediated Podocyte Injury in Diabetic Nephropathy
... In the field of kidney disease research, large-scale exome analysis shows that NHX1 plays an important role in the development of the kidney [5]. However, the function of NHX1 in glomerular podocytes has not been ...
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Tyro3 is a podocyte protective factor in glomerular disease
... We found that TYRO3 expression was localized mostly in podocytes in human kidneys and that its expression was markedly suppressed in the glomeruli of patients with progressive DKD and FSGS. Inter- estingly, TYRO3 ...
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CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease
... a podocyte source (Figure 1A and Supplemental Figure 1A; supplemental mate- rial available online with this article; ...to podocyte injury under these experimental ...
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