Podocyte Injury
Basic fibroblast growth factor augments podocyte injury and induces glomerulosclerosis in rats with experimental membranous nephropathy
... Podocyte injury is believed to contribute to glomerulosclerosis in membranous ...and podocyte damage in rats injected with 10% of the regular PHN- serum ...augment podocyte damage, resulting ...
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Local TNF causes NFATc1 dependent cholesterol mediated podocyte injury
... High levels of circulating TNF and its receptors, TNFR1 and TNFR2, predict the progression of diabetic kidney disease (DKD), but their contribution to organ damage in DKD remains largely unknown. Here, we investigated ...
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Mechanism of NHX1 Inhibiting TRPV5-Mediated Podocyte Injury in Diabetic Nephropathy
... [1]. Podocyte injury plays a crucial role in the progression of diabetic nephropathy and has received the attention of researchers in recent years ...affecting podocyte injury, apoptosis and ...
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Original Article Paricalcitol prevents glucose induced-podocyte injury by inhibiting Wnt/β-catenin pathway
... [12]. Podocyte-specific and tubule-specific knockout of β-catenin does not cause any overt abnor- mality, suggesting that the β-catenin protein is functionally dispensable in the kidney under normal physiological ...
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miRNAs Expression and Role of Dicer on Podocyte Injury in PAN Nephrosis Rats
... ysis. 3) Compared with control sample, immune fluorescence intensity of dicer, expression profile of nephrin, podocin and synaptopodin mRNA and protein decrease in PAN nephrosis rats. After treated with Leizhi Capsule, ...
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The protective effect and mechanism of catalpol on high glucose induced podocyte injury
... Methods: In this study, we used a high glucose (HG)-induced podocyte injury model to evaluate the protective effect and mechanism of catalpol against HG-induced podocyte injury. Cell viability ...
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The protective effect of Phellinus linteus decoction on podocyte injury in the kidney of FSGS rats
... [17]. Podocyte injury is a common feature of many glomerular diseases, which can lead to foot process fusion and cell detachment from the glom- erular base membrane, thus resulting in proteinuria and ...
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Original Article Wnt/β-catenin pathway involved in podocyte injury is regulated by UCH-L1
... Abnormalities in deubiquitination enzymes may influence the metabolism of important cellular proteins and cause disorders in cell function [14-17]. A recent report by Bheda and co-work- ers demonstrated that UCH-L1 ...
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Original Article Effects of hydrogen sulfide on high glucose-induced glomerular podocyte injury in mice
... (MPC) injury and the underlying ...induced podocyte injury, which is alleviated by exogenous H 2 S possibly through ZO-2 upregulation and the subsequent sup- pression of Wnt/β-catenin ...
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Podocyte injury elicits loss and recovery of cellular forces
... of podocyte cellular forces and the underlying mechanobiology preceding podocyte de- tachment in real ...contractile podocyte forces are transmitted via specific contact points formed in ...
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Intraglomerular crosstalk elaborately regulates podocyte injury and repair in diabetic patients: insights from a 3D multiscale modeling study
... glomerulus restoration from diabetic injury. We started from an injured glomerulus system manifesting abnormal glomerular cells and aberrant concentrations of critical signaling molecules (described in above ...
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Protective Effect of Valsartan on Podocyte Injury in Rats with Diabetic Nephropathy
... The podocyte membrane is the last barrier of glomerular filtration and plays a regulatory role in the production of proteinuria [8, ...the podocyte membrane and concentrates on the tight junction between ...
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Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease
... that podocyte-specific Klf15-KO mice in the unperturbed state did not develop significant proteinuria or glomerulosclerosis, but in Lipopolysaccharide (LPS) or Adriamycin (ADR)-induced proteinuric murine models, ...
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Vitamin D protects podocytes from autoantibodies induced injury in lupus nephritis by reducing aberrant autophagy
... In addition to its critical role in maintaining calcium and phosphorus homeostasis, recent data suggest that vitamin D insufficiency may play a role in the progres- sion of SLE and nephropathy such as chronic kidney dis- ...
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<p>Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy</p>
... barrier. Podocyte injury plays a key role in the increased microalbuminuria seen in DN, which is also characterized by a signi fi cant loss in podocyte numbers due to ...inhibiting podocyte ...
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The role of podocyte damage in the etiology of ischemia-reperfusion acute kidney injury and post-injury fibrosis
... interstitial injury during AKI. More recently, however, the involve- ment of podocyte injury as an etiological factor of progressive proteinuria and GFR decline (which can per- sist for several ...
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Qiwei granules alleviates podocyte lesion in kidney of diabetic KK Ay mice
... of podocyte were fusion and the GBM became thicker in KK-A y vehicle mice compared with normal ...the podocyte injury especially the foot process fusion was ...
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Podocyte specific RAP1GAP expression contributes to focal segmental glomerulosclerosis–associated glomerular injury
... directed at total RAP1 confirmed the absence of glomerular RAP1 expression in DKO mice (Figure 3B). Most DKO animals died from renal failure and massive proteinuria by 8 weeks of age (Figure 4, A and B). Pathological ...
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Tubular injury triggers podocyte dysfunction by β-catenin–driven release of MMP-7
... To further examine the effects of MMP-7 on nephrin depletion, we used human embryonic kidney cells (HEK-293 cells) transfected with nephrin expression vector and then incubated with recombinant MMP-7 (50 nM). Nephrin was ...
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The targeted podocyte
... The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural ...integrity. Podocyte injury and loss contribute to proteinuria and progressive ...
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