Polo-like kinase one
Polo-like kinase 4: the odd one out of the family
... from one another, as one is slightly longer and possesses two sets of appendages at its distal end (sub-distal and distal appendages) ...cyclin-dependent kinase 2 (Cdk2)/cyclin A/E [48,49] and Mps1 ...
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MICROWAVE ASSISTED SYNTHESIS AND MOLECULAR MODELING STUDIES OF SOME NOVEL POLO-LIKE KINASE 1 INHIBITORS AS ANTICANCER AND ANTI-INFLAMMATORY AGENTS
... A series of 1, 3-thiazolidin-4-one analogues were synthesized using microwave and structurally characterized by various spectroscopic techniques and elemental analysis. All synthesized compounds were screened for ...
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Roles of Polo-like kinase 3 in suppressing tumor angiogenesis
... Drosophila Polo, the founding member of a family of evolutionarily con- served protein serine/threonine ...kinases. Polo is involved in the regulation of mitosis and meiosis ...to Polo and to ...
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Polo-Like Kinase 1 Is Involved in Hepatitis C Virus Replication by Hyperphosphorylating NS5A
... (human kinase and phosphatase genes) subset of VSV-G pseudotyped lentiviruses expressing distinct shRNA was employed for ...investigation. Polo-like kinase 1 (Plk1), a serine/ threonine ...
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Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication
... condensation and separation are the critical steps in this process. Plk1 phosphorylation of Topoisomerase II- alpha at Serine 1337 and Serine 1534 increases its decate- nation activity, which is critical for ...
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Polo-Like Kinase 1 as a Target for Human Cytomegalovirus pp65 Lower Matrix Protein
... In one pull-down assay, a GST-Plk-C9 fusion and a GST attached to a Plk1-unrelated protein (UP) were compared for their ability to be captured by a natural pp65 immunopurified from HCMV-infected fibroblast ...
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Polo-like kinase 1 as target for cancer therapy
... Polo-like kinase 1 (Plk1) plays a critical role in cell div- ision and represents a promising target for cancer ther- ...of polo-like kinase 1 have been ...therapy. ...
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Exploration of Mutation and DNA Methylation of Polo Like Kinase 1 (PLK1) in Colorectal Cancer
... Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays critical roles in cell cycling and DNA damage ...identified. One of the mutation ...
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Polo-like kinase 4 at the nexus of epigenetic modifications and the DNA damage signaling network
... [102]. One PEST sequence is located near the kinase domain while the other two are near at the tail-end of the carboxy- terminal ...a kinase-active mutant of PLK4 is destabilized and quickly targeted ...
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Polo-Like Kinase Guides Cytokinesis in Trypanosoma brucei through an Indirect Means
... particular time and how it could regulate the initiation of cytokinesis while disappearing from FAZ ahead of the event. The use of an inhibitor of TbPLK, GW, and performance of TbPLK RNAi on T. brucei cells synchronized ...
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Polo like kinase confers MPF autoamplification competence to growing Xenopus oocytes
... The journal contacted the authors who said that some of the bands in western blots were duplicated during figure compilation. After discussion with Anthi Karaiskou and Catherine Jessus, Development referred this matter ...
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Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors
... AURK inhibitors have been advanced for the treatment of drug-resistant CML, including those driven by T315I BCR-ABL1 mutant, through the inhibition of BCR-ABL1 TK [43]. However, pan-AURK inhibitor clinical use has been ...
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Putting a bit into the polo-box domain of polo-like kinase 1
... present, one of the biggest challenges in developing 4j-based inhibitors is improving membrane permeabil- ity by minimizing the anionic change of the phos- phorylated Thr residue that is critical for PBD ...
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Impact of Polo-like kinase 1 inhibitors on human adipose tissue- derived mesenchymal stem cells
... is one of the most promising targets combating ...cells, like cardiac fibroblasts and endothelial cells [8, ...drugs like metformin, rapamycin or actinomycin D protects primary cells from mitotic ...
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The balance of Polo-like kinase 1 in tumorigenesis
... trials. One of the strate- gies is to deplete the expression of Plk1 by using anti-sense oligonucleotides (ASO) or small interfering RNA (siRNA) to block Plk1 translation or ...
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Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1)
... and confer resistance to GSK461364A when assayed individually (Figure 5). We reasoned that if silencing RARA could confer resistance to GSK461364A that activating its protein product with ligands could confer ...
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Co-inhibition of polo-like kinase 1 and aurora kinases promotes mitotic catastrophe
... Aurora kinase inhibitors are specific for the respective kinases, we replaced one of the inhibitors with siRNA against the kinase (see Figure 1 for the efficacy of the ...
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A TAT-conjugated peptide inhibitor of polo-like kinase 1 for in vivo tumor imaging
... diseases. One of the most attractive advantages of these methods is that they can monitor biological and anatomical changes in the body as well as detect disease in vivo and ...
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Polo-like kinase 2 acting as a promoter in human tumor cells with an abundance of TAp73
... We investigated whether PLK2 was able to phosphorylate TAp73 protein via Phos-tag™ WB assay. We tested this in UM-SCC1 cells with low expression levels of TAp73. Endogenous phosphorylation of TAp73 in UM-SCC1 clearly ...
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Polo-Like Kinase 1 phosphorylates and stabilizes KLF4 to promote tumorigenesis in nasopharyngeal carcinoma
... Figure 3. KLF4 is a newly identified substrate of PLK1. (A) Heatmap showed changes of KLF4 protein level in treated by different kinase inhibitors by western blot analysis. Calculate gray value with image J. (B) ...
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