Polo-like kinases
The Polo-like kinases as recipients and enablers of epigenetic modifications in tumourigenesis
... (NEB) was used a as a positive control where appropriate. Primers were designed via MethPrimer [37] within the CpG islands of each individual Plk gene (see Table 1). Global methylation levels for liver tissue were ...
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Characterization of the Sak kinase interaction with cyclin B1 and Gadd45a
... Polo-like Kinases Function and Members 1 The Structure of the Polo-like Kinases 2 Plks Expression and Kinase Activity 4.. Plks Localization 5.[r] ...
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Co-inhibition of polo-like kinase 1 and aurora kinases promotes mitotic catastrophe
... protein kinases including polo-like kinases and Aurora ...these kinases are frequently dysregulated in cancers, small-molecule inhibitors have been developed for targeted anticancer ...
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Polo-like kinase 4: the odd one out of the family
... Drosophila Polo kinase, ...centrosomal kinases NIMA and MPS1 than to C. elegans Polo-like kinases (PLK1-3) strongly suggesting that it did not arise through duplication of the PLK gene ...
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Roles of Polo-like kinase 3 in suppressing tumor angiogenesis
... Polo-like kinases (Plk) are named after Drosophila Polo, the founding member of a family of evolutionarily con- served protein serine/threonine ...kinases. Polo is involved in ...
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Polo kinases regulate C elegans embryonic polarity via binding to DYRK2 primed MEX 5 and MEX 6
... and polo-like kinases (PLKs) are serine/threonine kinases that regulate diverse processes during cell division, including centrosomal duplication and maturation, DNA damage checkpoint ...
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Polo-like kinase 1 as target for cancer therapy
... of polo-like kinase 1 have been ...therapy. Polo-like kinases are serine-threonine pro- tein ...different polo-like kinases (Plk 1-4), of which Plk1 is the best ...
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Polo-like kinase 4 at the nexus of epigenetic modifications and the DNA damage signaling network
... of Polo-like kinases in hematological malignancies, we considered the significance of the low oxygen tension innate to the bone marrow (BM) microenvironment in both normal and diseased ...
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Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication
... and Polo-like kinases (Plks) have been identified as key regulators of this ...that Polo-like kinase 1 (Plk1) plays critical roles in mitosis but little is known about its functions at ...
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Regulation of the Cell Division Cycle in Trypanosoma brucei
... and Polo-like kinases identified in other eu- karyotes, suggesting that trypanosomes may have evolved distinct TbAUK1- and TbPLK-mediated pathways for cytokinesis initia- ...the Polo box ...
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The balance of Polo-like kinase 1 in tumorigenesis
... Polo-like kinases (Plks) are serine/threonine kinases with an N-terminal kinase domain and a C-terminal polo-box domain. The domain structure of this family is evolution- ary conserved ...
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Polo-Like Kinase 1 Is Involved in Hepatitis C Virus Replication by Hyperphosphorylating NS5A
... Hepatitis C virus (HCV) replication involves many viral and host factors. Here, we employed a lentivirus- based RNA interference (RNAi) screening approach to search for possible cellular factors. By using a ...
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Polo-Like Kinase 1 as a Target for Human Cytomegalovirus pp65 Lower Matrix Protein
... top), like alpha- casein control ...and kinases other than Plk1 have the chance to phosphorylate pp65, as suggested by the in vivo pp65 phosphorylation in insect cells and by the efficient in vitro labeling ...
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The Hippo pathway in disease and therapy: cancer and beyond
... LATS1/2 kinases functioning upstream of YAP/ ...LATS1/2 kinases are regulated by multiple PPIs, which directly or indirectly affect their kinase activities [1,6,8,9,104], an in-depth characterisa- tion of ...
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Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1)
... in CML cells [4]. Here we used RNAi screening to look for sensitizers to the candidate cancer drug GSK461364A, a potent inhibitor of polo-like kinase 1 (PLK1) [5]. PLK1 is expressed during the G2/M phase of ...
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Polo-Like Kinase 1 phosphorylates and stabilizes KLF4 to promote tumorigenesis in nasopharyngeal carcinoma
... a polo-like kinase inhibitor would inhibit tumor cell growth in vivo, we evaluated the effects of BI6727 in S18 and S26 xenograft ...that polo-like kinase 1 inhibitor can play a potential ...
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Polo-like kinase 2 acting as a promoter in human tumor cells with an abundance of TAp73
... Materials and methods: Head and neck squamous cell carcinoma cell lines and osteosarcoma cell lines were used as natural models of the different expression levels of TAp73. Phosphoryla- tion predictor software Scansite ...
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Exploration of Mutation and DNA Methylation of Polo Like Kinase 1 (PLK1) in Colorectal Cancer
... Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays critical roles in cell cycling and DNA damage response. Overexpression of PLK1 is asso- ciated with the poorer prognosis of cancers, ...
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An Amino-Terminal Polo Kinase Interaction Motif Acts in the Regulation of Centrosome Formation and Reveals a Novel Function for centrosomin (cnn) in Drosophila
... only Polo consensus phosphorylation site encoded by the cnn ...low-affinity Polo-binding ...a Polo-dependent reaction in S2R+ tissue culture cells (Dobbelaere et ...was Polo dependent, the ...
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Comparative study among swimmers, water polo players and divers on mental toughness
... water polo players University held at Amritsar, Punjab, 2013 were 17 to 25 year of ...Water Polo and Swimming (p = .018), Water Polo and Diving (p = ...Water Polo and Diving (p = ...Water ...
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